Ashwaghosha Parthasarathi
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View article: Exposure–Response to High PM <sub>2.5</sub> Levels for Cardiovascular Events in High‐Risk Older Adults in Taiwan
Exposure–Response to High PM <sub>2.5</sub> Levels for Cardiovascular Events in High‐Risk Older Adults in Taiwan Open
Background Limited studies using individual‐level health outcome data exist from countries with a wider range of particulate matter with a diameter of <2.5 μm (PM 2.5 ) levels to illustrate the shape of the exposure–response curve across a…
View article: Unsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles
Unsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles Open
Background/Objectives: Asthma is a heterogeneous inflammatory airway disease. Periostin, a matricellular protein induced by interleukin-13, contributes to airway inflammation and remodeling. This study evaluated serum periostin as a diagno…
View article: An investigation of air pollution-induced temperature sensitivity and susceptibility to heat-related hospitalization in the Medicare population
An investigation of air pollution-induced temperature sensitivity and susceptibility to heat-related hospitalization in the Medicare population Open
Background: With rising temperatures and an aging US population, understanding how to prevent heat-related illness among older Americans will be an increasingly critical objective. Despite biological plausibility, no study to date has inve…
View article: Unveiling Silent Consequences: Impact of Pulmonary Tuberculosis on Lung Health and Functional Wellbeing after Treatment
Unveiling Silent Consequences: Impact of Pulmonary Tuberculosis on Lung Health and Functional Wellbeing after Treatment Open
Background: Pulmonary tuberculosis (TB) remains a major public health issue in India, with high incidence and mortality. The current literature on post-TB sequelae functional defects focuses heavily on spirometry, with conflicting obstruct…
View article: Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multicentric Cohort Study
Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multicentric Cohort Study Open
Arunachala S, Devapal S, Swamy DSN, Greeshma MV, Ul Hussain I, Siddaiah JB, et al. Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multic…
View article: Exposure-Response to High PM<sub>2.5</sub>Levels for Cardiovascular Events in High-risk Older Adults in Taiwan
Exposure-Response to High PM<sub>2.5</sub>Levels for Cardiovascular Events in High-risk Older Adults in Taiwan Open
Background Multiple studies from countries with relatively lower PM 2.5 level demonstrated that acute and chronic exposure even at lower than recommended level, e.g., 9 μg/m 3 in the US increased the risk of cardiovascular (CV) events. How…
View article: Ambient heat exposure patterns and emergency department visits and hospitalizations among medicare beneficiaries 2008–2019
Ambient heat exposure patterns and emergency department visits and hospitalizations among medicare beneficiaries 2008–2019 Open
Among Medicare beneficiaries from 2008 to 2019, exposure to daily mean temperature ≥ 95th percentile was associated with increased risk of heat-related ED visits, with stronger associations seen among beneficiaries <65, males, and patients…
View article: The Validity of the ROX Index and APACHE II in Predicting Early, Late, and Non-Responses to Non-Invasive Ventilation in Patients with COVID-19 in a Low-Resource Setting
The Validity of the ROX Index and APACHE II in Predicting Early, Late, and Non-Responses to Non-Invasive Ventilation in Patients with COVID-19 in a Low-Resource Setting Open
The use of the Ratio of Oxygen Saturation (ROX) index to predict the success of high-flow nasal oxygenation (HFNO) is well established. The ROX can also predict the need for intubation, mortality, and is easier to calculate compared with A…
View article: The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study
The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study Open
High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMIC…
View article: Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults
Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults Open
Objective To evaluate the synergistic effects created by fine particulate matter (PM 2.5 ) and corticosteroid use on hospitalisation and mortality in older adults at high risk for cardiovascular thromboembolic events (CTEs). Design and set…
View article: Circulatory Serum Krebs von Den Lungen-6 and Surfactant Protein-D Concentrations Predict Interstitial Lung Disease Progression and Mortality
Circulatory Serum Krebs von Den Lungen-6 and Surfactant Protein-D Concentrations Predict Interstitial Lung Disease Progression and Mortality Open
There is a need for biomarkers to predict outcomes, including mortality, in interstitial lung disease (ILD). Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) are associated with lung damage and fibrosis in all ILDs and are rel…
View article: Association between ADAM33 Single-Nucleotide Polymorphisms and Treatment Response to Inhaled Corticosteroids and a Long-Acting Beta-Agonist in Asthma
Association between ADAM33 Single-Nucleotide Polymorphisms and Treatment Response to Inhaled Corticosteroids and a Long-Acting Beta-Agonist in Asthma Open
ADAM33 has been linked to airway structural changes in patients with asthma, leading to airway hyperresponsiveness, narrowing, and ultimately poor treatment responsiveness. This study aimed to evaluate the genetic association of ADAM33 SNP…
View article: A retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults
A retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults Open
Objective To evaluate the synergistic effects created by fine particulate matter (PM 2.5 ) and corticosteroid use on hospitalization and mortality in older adults at high-risk for cardiovascular thromboembolic events (CTEs). Design and Set…
View article: Impact of Acute Exacerbation and Its Phenotypes on the Clinical Outcomes of Chronic Obstructive Pulmonary Disease in Hospitalized Patients: A Cross-Sectional Study
Impact of Acute Exacerbation and Its Phenotypes on the Clinical Outcomes of Chronic Obstructive Pulmonary Disease in Hospitalized Patients: A Cross-Sectional Study Open
Acute exacerbations of COPD (AECOPD) are clinically significant events having therapeutic and prognostic consequences. However, there is a lot of variation in its clinical manifestations described by phenotypes. The phenotypes of AECOPD we…
View article: Association of Serum Albumin and Copeptin with Early Clinical Deterioration and Instability in Community-Acquired Pneumonia
Association of Serum Albumin and Copeptin with Early Clinical Deterioration and Instability in Community-Acquired Pneumonia Open
Background: There is a paucity of data on biomarkers for the early deterioration and clinical instability of patients in community-acquired pneumonia (CAP), as treatment failure occurs in the first seven days in 90% of patients. Aim: To ev…
View article: The Role of Neutrophil-to-Lymphocyte Ratio in Risk Stratification and Prognostication of COVID-19: A Systematic Review and Meta-Analysis
The Role of Neutrophil-to-Lymphocyte Ratio in Risk Stratification and Prognostication of COVID-19: A Systematic Review and Meta-Analysis Open
Several studies have proposed that the neutrophil–lymphocyte ratio (NLR) is one of the various biomarkers that can be useful in assessing COVID-19 disease-related outcomes. Our systematic review analyzes the relationship between on-admissi…
View article: Willingness to Accept the COVID-19 Vaccine and Related Factors among Indian Adults: A Cross-Sectional Study
Willingness to Accept the COVID-19 Vaccine and Related Factors among Indian Adults: A Cross-Sectional Study Open
To achieve herd immunity to a disease, a large portion of the population needs to be vaccinated, which is possible only when there is broad acceptance of the vaccine within the community. Thus, policymakers need to understand how the gener…
View article: The association of tobacco use in adolescents with their interpersonal surroundings and assessing tobacco vendor compliance with COPTA policies: A cross-sectional study
The association of tobacco use in adolescents with their interpersonal surroundings and assessing tobacco vendor compliance with COPTA policies: A cross-sectional study Open
Introduction: The prevalence of tobacco consumption is increasing globally and in South-east Asian countries. Despite the government's efforts in passing the laws for monitoring tobacco consumption, their effectiveness is questionable. The…
View article: Global intention of the general public to undergo COVID-19 vaccination: time trends and risk factors for vaccine refusal, a Systematic Review and Meta-analysis
Global intention of the general public to undergo COVID-19 vaccination: time trends and risk factors for vaccine refusal, a Systematic Review and Meta-analysis Open
Background: Knowledge of facilitators and barriers regarding the uptake of COVID-19 vaccination at a global population level is critical for combating the pandemic, saving lives, and protecting the economy. The aim of this work was to dete…
View article: Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort
Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort Open
Supplementary data for "Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort"
View article: Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort
Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort Open
Supplementary data for "Clinical Characterisation of Asthma with Fungal Sensitisation in a South Indian Paediatric Cohort"
View article: The extent of formal tobacco cessation training received by student health professionals and the prevalence of tobacco use among them: a cross-sectional study
The extent of formal tobacco cessation training received by student health professionals and the prevalence of tobacco use among them: a cross-sectional study Open
Background: Advice from health care professionals (HCPs) is critical for tobacco prevention and cessation efforts. The academic curricula for health care professional students (HCS) lack comprehensive training in assisting patients in toba…
View article: The extent of formal tobacco cessation training received by student health professionals and the prevalence of tobacco use among them: a cross-sectional study
The extent of formal tobacco cessation training received by student health professionals and the prevalence of tobacco use among them: a cross-sectional study Open
Background: Advice from health care professionals (HCPs) is critical for tobacco prevention and cessation efforts. The academic curricula for health care professional students (HCS) lack comprehensive training in assisting patients in toba…
View article: Fibrinogen: A Feasible Biomarker in Identifying the Severity and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Fibrinogen: A Feasible Biomarker in Identifying the Severity and Acute Exacerbation of Chronic Obstructive Pulmonary Disease Open
Background Chronic obstructive pulmonary disease (COPD) is no longer considered a disease exclusive to the respiratory system. It is a multipronged disease with both lung and systemic involvement. Although the forced expiratory volume (FEV…