Anand Viswanathan
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View article: In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy Open
Leakage of gadolinium-based contrast agent through the BBB can be measured in vivo in CAA from the leptomeningeal vessels, and findings point to likely leakage from cortical small vessels as well. Leakage from leptomeningeal vessels was as…
View article: Identifying high efficacy potential targets in Alzheimer’s disease by a mechanistic comparison with prion diseases
Identifying high efficacy potential targets in Alzheimer’s disease by a mechanistic comparison with prion diseases Open
Prion diseases and Alzheimer’s disease share many similarities in seeding activity, symptomatic and pathological presentations, and mechanisms of neurodegeneration. Accordingly, it is pertinent to inquire whether Alzheimer’s should be cons…
View article: Diagnosis and management of cerebral amyloid angiopathy: a scientific statement from the International CAA Association and the World Stroke Organization
Diagnosis and management of cerebral amyloid angiopathy: a scientific statement from the International CAA Association and the World Stroke Organization Open
Cerebral amyloid angiopathy (CAA) is a well-recognized and challenging disease for neurologists and other clinicians caring for the rapidly aging worldwide population. CAA is a major cause of spontaneous lobar intracerebral hemorrhage (ICH…
View article: Volume Tolerance and Prognostic Impact of Hematoma Expansion in Deep and Lobar Intracerebral Hemorrhage
Volume Tolerance and Prognostic Impact of Hematoma Expansion in Deep and Lobar Intracerebral Hemorrhage Open
BACKGROUND: The prognostic impact of intracerebral hemorrhage (ICH) volume varies according to location, with smaller volume tolerance in deep ICH, and hematoma expansion (HE) contributes to final ICH volume. We tested the hypothesis that …
View article: Cerebrospinal Fluid Beta‐Amyloid Concentration and Clinical and Radiographic Manifestations of Cerebral Amyloid Angiopathy
Cerebrospinal Fluid Beta‐Amyloid Concentration and Clinical and Radiographic Manifestations of Cerebral Amyloid Angiopathy Open
Background Cerebral amyloid angiopathy (CAA) is driven by vascular Aβ (amyloid‐beta) deposition, which can be detected as reduced Aβ species in cerebrospinal fluid (CSF). We sought to identify relationships between CSF Aβ and tau concentra…
View article: Late-onset unexplained seizures are associated with cognitive impairment and lower amygdala volumes
Late-onset unexplained seizures are associated with cognitive impairment and lower amygdala volumes Open
Late-onset epilepsy has been linked with accelerated cognitive decline and a higher risk of dementia. In this study, we sought to characterize the cognitive profile of participants with late-onset unexplained epilepsy and compare their MRI…
View article: Association of Blood Pressure Mean and Variability with Hippocampal Subfield Volumes in Cerebral Amyloid Angiopathy with Mild Cognitive Symptoms
Association of Blood Pressure Mean and Variability with Hippocampal Subfield Volumes in Cerebral Amyloid Angiopathy with Mild Cognitive Symptoms Open
Background The interaction between Alzheimer's pathology and cerebral amyloid angiopathy (CAA), a common cerebral small vessel disease, plays a crucial role in cognitive impairment development in older adults. Recent studies suggest that i…
View article: Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures
Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures Open
Our results reveal a spatial association between the epileptogenic focus and tau deposition, amyloid deposition, and neurodegeneration in early clinical stages of AD. Within the limitations of a cross-sectional study with small sample size…
View article: Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study
Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study Open
Background and hypothesis It remains unclear whether the relation of chronic kidney disease (CKD) with cognitive dysfunction is independent of blood pressure (BP). We evaluated kidney function in relation to premorbid BP measurements, cere…
View article: Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study
Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study Open
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on the long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess the long-term case…
View article: Association of Long-Term Blood Pressure Variability with Cerebral Amyloid Angiopathy-related Brain Injury and Cognitive Decline
Association of Long-Term Blood Pressure Variability with Cerebral Amyloid Angiopathy-related Brain Injury and Cognitive Decline Open
Introduction Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate the association between long-term blood pres…
View article: In vivo imaging of gadolinium-based contrast agent leakage in patients with cerebral amyloid angiopathy
In vivo imaging of gadolinium-based contrast agent leakage in patients with cerebral amyloid angiopathy Open
Introduction: Blood-brain barrier (BBB) leakage is hypothesized to be an early step in the pathophysiology of cerebral amyloid angiopathy (CAA), possibly preceding vessel wall breakdown and hemorrhage. This study aims (1) to measure BBB le…
View article: Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy
Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy Open
These results suggest that hippocampal integrity is an independent contributor to cognitive impairment in patients with CAA and that it might be related to loss of integrity in the white matter. Further studies exploring potential causes a…
View article: Abstract 072: Risk Factors for Developing Ischemic Strokes While Taking Non‐Vitamin K Antagonist Oral Anticoagulants
Abstract 072: Risk Factors for Developing Ischemic Strokes While Taking Non‐Vitamin K Antagonist Oral Anticoagulants Open
Introduction Over the past decade, non‐vitamin K antagonist oral anticoagulants (NOACs) have replaced warfarin as the initial strategy for stroke prevention in non‐valvular atrial fibrillation. However, ischemic strokes occurring in patien…
View article: Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study
Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study Open
BACKGROUND: Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dem…
View article: Association Between Hematoma Expansion Severity and Outcome and Its Interaction With Baseline Intracerebral Hemorrhage Volume
Association Between Hematoma Expansion Severity and Outcome and Its Interaction With Baseline Intracerebral Hemorrhage Volume Open
The strongest association between HE and outcome was observed in patients with smaller initial volume experiencing severe HE. These findings may inform clinical trial design and guide clinicians in selecting patients for antiexpansion ther…
View article: Histopathological Correlates of Lobar Microbleeds in False‐Positive Cerebral Amyloid Angiopathy Cases
Histopathological Correlates of Lobar Microbleeds in False‐Positive Cerebral Amyloid Angiopathy Cases Open
Objective A definite diagnosis of cerebral amyloid angiopathy (CAA), characterized by the accumulation of amyloid β in walls of cerebral small vessels, can only be obtained through pathological examination. A diagnosis of probable CAA duri…
View article: Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy
Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy Open
Background Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which can be measured by the Peak Width of Skeletonized Mean Diffusivity (PSMD). We hypothesi…
View article: Apathy in Patients With Cerebral Amyloid Angiopathy
Apathy in Patients With Cerebral Amyloid Angiopathy Open
Our findings revealed the orbitofrontal cortex as a key region in the reward circuit associated with apathy in sporadic cerebral amyloid angiopathy, independent from depression. Apathy was shown to be associated with a higher CAA-SVD score…
View article: Peak Width of Skeletonized Mean Diffusivity: A Neuroimaging Marker for White Matter Injury
Peak Width of Skeletonized Mean Diffusivity: A Neuroimaging Marker for White Matter Injury Open
A leading cause of white matter (WM) injury in older individuals is cerebral small vessel disease (SVD). Cerebral SVD is the most prevalent vascular contributor to cognitive impairment and dementia. Therapeutic progress for cerebral SVD an…
View article: Sex Differences in Onset and Progression of Cerebral Amyloid Angiopathy
Sex Differences in Onset and Progression of Cerebral Amyloid Angiopathy Open
Background: Cerebral Amyloid Angiopathy (CAA) disease course is highly variable even in hereditary forms. Sex may be a possible modifying factor. We investigated biological sex differences in clinical disease course and magnetic resonance …
View article: Poststroke Disability: Association Between Sex and Patient-Reported Outcomes
Poststroke Disability: Association Between Sex and Patient-Reported Outcomes Open
Background: Ischemic stroke (IS) is a leading cause of long-term disability with sex-specific differences in outcomes. Identifying the influential factors that contribute to sex-specific disparities in stroke outcomes, therefore, holds pot…
View article: Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion
Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion Open
Background: Noncontrast computed tomography hypodensities are a validated predictor of hematoma expansion (HE) in intracerebral hemorrhage and a possible alternative to the computed tomography angiography (CTA) spot sign but their added va…
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.Ple…
View article: Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage
Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage Open
Background: Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intracerebral hemorrhage (ICH). However, fewer than half of ICH survivors achieve target treatment goals. ICH sur…
View article: Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations Open
Background Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context of different cerebral small vessel diseases (cSVD). P…
View article: Teaching NeuroImage: Acute Onset Gait Instability and Lateropulsion Secondary to Cerebellar Vermis Stroke
Teaching NeuroImage: Acute Onset Gait Instability and Lateropulsion Secondary to Cerebellar Vermis Stroke Open
A 65-year-old woman with hypertension, hyperlipidemia, ascending aortic aneurysm repair and valve replacement, and periprocedural atrial fibrillation (not on anticoagulation) presented with sudden-onset imbalance. The patient was on a trea…
View article: Blood Pressure Control Targets and Risk of Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage
Blood Pressure Control Targets and Risk of Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage Open
Background: Intracerebral hemorrhage (ICH) survivors are at high risk for recurrent stroke and cardiovascular events. Blood pressure (BP) control represents the most potent intervention to lower these risks, but optimal treatment targets i…