Asif Iqbal
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View article: Simulating the Transmural Mechanical Response of Functionally Graded Arterial Grafts
Simulating the Transmural Mechanical Response of Functionally Graded Arterial Grafts Open
With coronary artery disease remaining the leading cause of mortality worldwide, the design and manufacture of clinically viable synthetic coronary artery grafts remains a fundamental healthcare challenge. It is widely accepted that vascul…
View article: The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn’s disease during the first year of treatment: a prospective observational cohort study
The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn’s disease during the first year of treatment: a prospective observational cohort study Open
Background Inflammatory bowel disease (IBD) is linked with increased prevalence of mental health disorders (MHD), particularly anxiety and depression. How this influences treatment outcomes in the first year after diagnosis is poorly studi…
View article: PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease
PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease Open
Current osteoporosis therapies are limited by their inability to fully restore bone homeostasis and significant side effects through long-term use. PEPITEM is an endogenous 14 amino acid osteogenic peptide capable of stimulating osteoblast…
View article: Menopause and Inflammatory Bowel Disease: A Systematic Review
Menopause and Inflammatory Bowel Disease: A Systematic Review Open
Background Research is limited on the impacts of menopause, defined as the permanent cessation of ovarian function and decline of reproductive hormones, on gastrointestinal symptom severity and disease progression in women with inflammator…
View article: Differential expression of endothelial derived galectins in response to shear stress
Differential expression of endothelial derived galectins in response to shear stress Open
These findings highlight that endothelial galectin expression is shear-regulated, which has significant implications for understanding galectin biology and there potential as therapeutic targets in vascular diseases influenced by shear str…
View article: Dichotomous effects of Galectin-9 in disease modulation in murine models of inflammatory bowel disease
Dichotomous effects of Galectin-9 in disease modulation in murine models of inflammatory bowel disease Open
Inflammatory bowel disease (IBD) is a multifaceted disease characterised by compromised integrity of the epithelial barrier, the gut microbiome, and mucosal inflammation. While leukocyte recruitment and infiltration into intestinal tissue …
View article: MENOPAUSE AND INFLAMMATORY BOWEL DISEASE: SYSTEMATIC REVIEW
MENOPAUSE AND INFLAMMATORY BOWEL DISEASE: SYSTEMATIC REVIEW Open
BACKGROUND AND AIMS Women with inflammatory bowel disease (IBD) report that their IBD symptoms change due to menses and hormonal contraception. However, research is limited on the impacts of menopause, which is the absence of menstrual per…
View article: P0401 The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn’s disease during the first year of treatment
P0401 The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn’s disease during the first year of treatment Open
Background Inflammatory bowel disease (IBD) is linked with increased prevalence of mental health diseases (MHD), particularly anxiety and depression. How this influences treatment outcomes is poorly studied at IBD diagnosis. The IBD disk i…
View article: Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India
Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India Open
Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population’s vulnerabil…
View article: Effect of Proanthocyanidins from Grape Seed Extract on Benign Prostatic Hyperplasia
Effect of Proanthocyanidins from Grape Seed Extract on Benign Prostatic Hyperplasia Open
Background/Objectives: Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases affecting the urinary tract that occurs mainly in men over 40 years of age. Among the natural therapies, proanthocyanidins (PACs), which c…
View article: Physical Characterisation of pre‐clinical progressive model of Alzheimer’s Disease
Physical Characterisation of pre‐clinical progressive model of Alzheimer’s Disease Open
Background Alzheimer’s Disease research lacks a suitable model to match the sporadic version of Alzheimer’s Disease (SAD). We a propose a model that will use 7PA2 cells which is a CHO modified to express the V717F mutation for APP (Indiana…
View article: PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions
PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions Open
PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs). Here we identify two independently active tripeptide pharmacophores within PEPITEM and engineered …
View article: Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention
Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention Open
Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on leukocyte migration in…
View article: Experience Matters: Turning Psychopathy into Self-Efficacy and Job Performance
Experience Matters: Turning Psychopathy into Self-Efficacy and Job Performance Open
Using the tenets of social cognitive theory, this study diverges significantly from the conventional research paradigm by shedding light on the pivotal role of job experience and self-efficacy in predicting psychopath's job performance. In…
View article: BS32 Evaluating the expression and role of chemokine receptors in CD4+CD28null T cells from patients with acute coronary syndrome
BS32 Evaluating the expression and role of chemokine receptors in CD4+CD28null T cells from patients with acute coronary syndrome Open
Rationale Chemokines and their receptors have important roles in dysregulated leukocyte migration which drives Acute Coronary Syndrome (ACS). CD4+CD28null (CD28null) T lymphocytes are unique T cells which expand in a subgroup of ACS patien…
View article: Optimising triage of urgent referrals for suspected IBD: results from the Birmingham IBD inception study
Optimising triage of urgent referrals for suspected IBD: results from the Birmingham IBD inception study Open
Objective Diagnostic delays in inflammatory bowel disease (IBD) result in adverse outcomes. We report a bespoke diagnostic pathway to assess how best to combine clinical history and faecal calprotectin (FCP) for early diagnosis and efficie…
View article: Interplay in galectin expression predicts patient outcomes in a spatially restricted manner in PDAC
Interplay in galectin expression predicts patient outcomes in a spatially restricted manner in PDAC Open
In summary, the intricate interplay and cell-specific expression patterns of galectins within the PDAC tissue, particularly the inverse correlation between Gal-1 and Gal-4 in ducts and its significant association with patient survival, hig…
View article: Phase and microstructural characterization of swat soapstone (Mg<sub>3</sub>Si<sub>4</sub>O<sub>10</sub>(OH)<sub>2</sub>)
Phase and microstructural characterization of swat soapstone (Mg<sub>3</sub>Si<sub>4</sub>O<sub>10</sub>(OH)<sub>2</sub>) Open
This study focuses on the comprehensive exploration of Swat soapstone, employing a range of analytical techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectroscopy, Fourier-t…
View article: P391 A not so innocent bystander: The prevalence and burden of anaemia at IBD onset
P391 A not so innocent bystander: The prevalence and burden of anaemia at IBD onset Open
Background Anaemia is the most common systemic complication of Inflammatory Bowel Disease (IBD). Contemporary studies linking its prevalence with symptom burden at disease onset are limited. We present the prevalence and disability associa…