Md Jamal Uddin
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View article: Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects
Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects Open
Respiratory diseases are associated with high mortality worldwide. Respiratory infections can lead to the emergence of chronic respiratory diseases. Scientists are constantly striving to identify new therapies with reduced side effects. Th…
View article: Age and Gender Specific Pulmonary and Extrapulmonary Tuberculosis in a Rural Area of Bangladesh
Age and Gender Specific Pulmonary and Extrapulmonary Tuberculosis in a Rural Area of Bangladesh Open
Background: Tuberculosis (TB) remains a major public health concern in Bangladesh, with significant variability in its demographic, clinical, and management aspects. Objective: This study aims to assess the age and genderspecific burden of…
View article: Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan
Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan Open
Hepatitis C virus (HCV) poses a global health challenge, especially due to its genetic diversity and capacity to infect 71 million people worldwide. This infection is prevalent in Pakistan, with 15% of the population affected, with varying…
View article: Vascularization of Human Pancreatic Islets With Adaptive Endothelial Cells for In Vitro Analysis and In Vivo Transplantation
Vascularization of Human Pancreatic Islets With Adaptive Endothelial Cells for In Vitro Analysis and In Vivo Transplantation Open
The pancreatic islet, the only type of tissue that secretes insulin in response to elevated blood glucose, plays a vital role in diabetes development and treatment. While various islet vascularization strategies have been developed, they h…
View article: Protective Mechanisms of Carica papaya Leaf Extract and Its Bioactive Compounds Against Dengue: Insights and Prospects
Protective Mechanisms of Carica papaya Leaf Extract and Its Bioactive Compounds Against Dengue: Insights and Prospects Open
Dengue fever is currently a major global issue, especially in tropical and subtropical countries. The absence of specific antiviral medications supports alternative dengue treatment strategies. South Asian countries have been using Carica …
View article: Breaking boundaries: Revolutionizing healthcare with agile methodology
Breaking boundaries: Revolutionizing healthcare with agile methodology Open
Recent developments in patient care delivery are faced with many barriers across different levels globally, including the need to provide care that is high quality, affordable, and dynamic (Smith et al, 2022). The Agile approach, which is …
View article: Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus
Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus Open
This review delves into the historical context, current epidemiological landscape, genomics, and pathobiology of monkeypox virus (MPXV). Furthermore, it elucidates the present vaccination status and strategies to curb the spread of monkeyp…
View article: FDA Modernization Act 2.0: An insight from nondeveloping country
FDA Modernization Act 2.0: An insight from nondeveloping country Open
Animal testing is required in drug development research and is crucial for assessing the efficacy and safety of medications before they are commercialized. However, the newly furnished Food and Drug Administration Modernization Act 2.0 has…
View article: Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
Pharmacological potentials of lycopene against aging and aging‐related disorders: A review Open
Aging and aging‐related chronic disorders are one of the principal causes of death worldwide. The prevalence of these disorders is increasing gradually and globally. Considering this unwavering acceleration of the global burden, seeking al…
View article: Identification of Therapeutic Leads from<i>Ficus hispida</i>Fruit Phytochemicals against Prostate Cancer Using Pharmacoinformatic and Molecular Dynamics Simulation Approach
Identification of Therapeutic Leads from<i>Ficus hispida</i>Fruit Phytochemicals against Prostate Cancer Using Pharmacoinformatic and Molecular Dynamics Simulation Approach Open
Prostate cancer is one of the leading causes of death and the most common cancer type in men. In this study, potential leads from the phytochemicals of Ficus hispida fruit were screened using in silico tools against androgen receptor (AR),…
View article: Pernicious Attitude of Microbial Biofilms in Agri-Farm Industries: Acquisitions and Challenges of Existing Antibiofilm Approaches
Pernicious Attitude of Microbial Biofilms in Agri-Farm Industries: Acquisitions and Challenges of Existing Antibiofilm Approaches Open
Biofilm is a complex matrix made up of extracellular polysaccharides, DNA, and proteins that protect bacteria against physical, chemical, and biological stresses and allow them to survive in harsh environments. Safe and healthy foods are m…
View article: Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Open
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism of lipid and reactiv…
View article: An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1
An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1 Open
Fibrosis is a hallmark of progressive kidney diseases. The overexpression of profibrotic cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and tissue damage, induces kidney fibrosis. The inhibition of TGF-…
View article: Editorial: Novel pharmacological approaches targeting mitochondrial dysfunction in diseases
Editorial: Novel pharmacological approaches targeting mitochondrial dysfunction in diseases Open
EDITORIAL article Front. Pharmacol., 04 October 2022Sec. Experimental Pharmacology and Drug Discovery Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1041576
View article: Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach
Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach Open
Convolvulus pluricaulis (CP), a Medhya Rasayana (nootropic) herb, is a major ingredient in Ayurvedic and Traditional Chinese formulae indicated for neurological conditions, namely, dementia, anxiety, depression, insanity, and epilepsy. Exp…
View article: Dendritic Cells (DCs)-Based Cancer Immunotherapy: A Review on the Prospects of Medicinal Plants and Their Phytochemicals as Potential Pharmacological Modulators
Dendritic Cells (DCs)-Based Cancer Immunotherapy: A Review on the Prospects of Medicinal Plants and Their Phytochemicals as Potential Pharmacological Modulators Open
Dendritic cells (DCs) are specialized antigen-presenting cells in humans and animals that provide antigen-specific T-cell immunity in the body. It also establishes a linkage between innate and adaptive immune responses. Various studies hav…
View article: Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction
Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction Open
Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have become critical clinical, socioeconomic, and public health concerns worldwide. The kidney requires a lot of energy, and mitochondria act as the cen…
View article: Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Open
The present data highlight the importance of PPARα-mediated peroxisomal fitness in the protective effect of fenofibrate against NAFLD.
View article: A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights
A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights Open
Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evid…
View article: Semi-Scavenging Poultry as Carriers of Avian Influenza Genes
Semi-Scavenging Poultry as Carriers of Avian Influenza Genes Open
Ducks are the natural reservoir of influenza A virus and the central host for the avian influenza virus (AIV) subtype H5N1, which is highly pathogenic. Semi-scavenging domestic ducks allow for the reemergence of new influenza subtypes whic…
View article: Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives
Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives Open
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patien…
View article: EXPRESSION PROFILE OF SARS-COV-2 ENTRY RECEPTOR ACE2 IN THE HEPATOCELLULAR CARCINOMA AND ITS IMPACT ON COVID-19 PATIENTS
EXPRESSION PROFILE OF SARS-COV-2 ENTRY RECEPTOR ACE2 IN THE HEPATOCELLULAR CARCINOMA AND ITS IMPACT ON COVID-19 PATIENTS Open
The SARS-CoV-2 infection leads to liver injury and promotes other viral infections such as hepatitis B virus (HBV) in COVID-19 patients. Obesity is involved with an increased risk of mortality in hepatocellular carcinoma (HCC) patients. In…
View article: p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets
p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets Open
The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor suppressor protein that has multiple aspects o…
View article: A perspective on the therapeutic potential of Moringa oleifera and its metabolites against emerging COVID-19 pandemic
A perspective on the therapeutic potential of Moringa oleifera and its metabolites against emerging COVID-19 pandemic Open
As the pathobiology of coronavirus disease-19 (COVID-19) has been complicated by pre-existing conditions such as diabetes, cardiovascular diseases (CVD), chronic kidney disease (CKD) and respiratory illness to which inflammation, oxidative…
View article: Antioxidant, anticholinesterase and neurotrophic potentials of indigenous medicinal herbs of Bangladesh
Antioxidant, anticholinesterase and neurotrophic potentials of indigenous medicinal herbs of Bangladesh Open
In Ayurvedic system of medicine, a variety of medicinal herbs are being prescribed for brain disorders, including mental dysfunction, indifference, and memory impairment. Neuropharmacological mechanisms of these herbs are poorly understood…
View article: Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances Open
Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a m…
View article: Prospects for Protective Potential of Moringa oleifera against Kidney Diseases
Prospects for Protective Potential of Moringa oleifera against Kidney Diseases Open
Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as …
View article: Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives Open
CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The…