Asko Wegelius
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View article: Suicidal acts and thoughts among persons with psychotic disorders in the Finnish SUPER study
Suicidal acts and thoughts among persons with psychotic disorders in the Finnish SUPER study Open
Background Psychotic disorders, including schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), psychotic depression (PD), and other nonaffective psychoses (ONAP), are associated with increased risk of suicidal acts. F…
View article: Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone users
Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone users Open
Non-adherence and negative attitudes towards medication are major problems in treating psychotic disorders. Cytochrome P450 2D6 (CYP2D6) contributes to the metabolism of aripiprazole and risperidone, and variations in CYP2D6 activity may a…
View article: Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders
Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders Open
Background Sleep problems are common in psychotic disorders and are associated with worse quality of life and disease prognosis. Genome-wide association studies (GWAS) have revealed genetic influences for schizophrenia and sleep, but polyg…
View article: General medical comorbidities in psychotic disorders in the Finnish SUPER study
General medical comorbidities in psychotic disorders in the Finnish SUPER study Open
Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk f…
View article: Cognitive behavioural therapy for insomnia (CBT-I) in schizophrenia and schizoaffective disorder: protocol for a randomised controlled trial
Cognitive behavioural therapy for insomnia (CBT-I) in schizophrenia and schizoaffective disorder: protocol for a randomised controlled trial Open
Introduction Insomnia is a common symptom among patients with schizophrenia and schizoaffective disorder, negatively impacting symptom severity, functioning and well-being; however, it is rarely the direct focus of treatment. The main reco…
View article: Antipsychotic medications and sleep problems in patients with schizophrenia
Antipsychotic medications and sleep problems in patients with schizophrenia Open
View article: Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders
Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders Open
View article: Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia
Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia Open
View article: Influence of Cyp2d6 Phenotype on Adherence, Adverse Effects, and Attitudes Towards Antipsychotic Treatment in Aripiprazole and Risperidone Users
Influence of Cyp2d6 Phenotype on Adherence, Adverse Effects, and Attitudes Towards Antipsychotic Treatment in Aripiprazole and Risperidone Users Open
View article: The impact of rare protein coding genetic variation on adult cognitive function
The impact of rare protein coding genetic variation on adult cognitive function Open
Compelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact cognitive function in the adult population ( n…
View article: Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders
Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders Open
Purpose SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to …
View article: Substance Use and Sleep Problems in Patients With Psychotic Disorders
Substance Use and Sleep Problems in Patients With Psychotic Disorders Open
Background Substance use and sleep problems are common in patients with psychotic disorders, but their associations in these patients have not been evaluated. We aimed to investigate associations between substance use and sleep problems in…
View article: Virtual reality intervention for psychotic disorders using 360-degree video - agile development of an easy to implement protocol
Virtual reality intervention for psychotic disorders using 360-degree video - agile development of an easy to implement protocol Open
Background Virtual reality technologies have been utilized in the treatment of psychiatric disorders by offering means to practice challenging situations in a safe environment. In this case report, we describe the development of a novel an…
View article: Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study
Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study Open
Level of functioning and psychosocial outcomes differed markedly between psychotic disorders, particularly in independent living. Outcomes were worst for schizophrenia and best for BD. Across all psychotic disorders, female gender and life…
View article: Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder
Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder Open
View article: Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study
Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study Open
Objective Characterizing sleep in patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression. Methods This cross-sectional questionnaire study is based on the SUPER study sample, which is part of the …
View article: Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Open
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS…
View article: Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder.
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder. Open
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder…
View article: Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder Open
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder…
View article: Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder Open
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol related disorder in persons with bipolar disorder (BD). The study population included 1,268 persons from Finland with bipolar disorde…
View article: Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder.
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder. Open
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaff…
View article: Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder Open
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaff…
View article: Reaction Time and Visual Memory in Connection to Alcohol Use In Schizophrenia and Schizoaffective Disorder
Reaction Time and Visual Memory in Connection to Alcohol Use In Schizophrenia and Schizoaffective Disorder Open
Purpose of the study was to explore the association of cognition with hazardous drinking, binge drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognitive deficits are common in schizophrenia. Alcohol might …
View article: Implementation of <i>CYP2D6</i> copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder
Implementation of <i>CYP2D6</i> copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder Open
Purpose We constructed a CYP2D6 copy-number imputation panel by combining copy-number information to GWAS chip data. In addition, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genet…
View article: Anxiety symptoms in first‐episode psychosis
Anxiety symptoms in first‐episode psychosis Open
Aim Anxiety disorders and symptoms are common in people with psychotic disorders, having a negative impact on clinical status, function level and overall prognosis. However, research on the significance of anxiety in predicting remission a…
View article: Digital health technologies in the psychosocial treatment of core symptoms of psychotic disorders - literature review and practical aspects
Digital health technologies in the psychosocial treatment of core symptoms of psychotic disorders - literature review and practical aspects Open
The use of various digital health technologies is increasing in the treatment of psychotic disorders, as well as in psychiatry in general. In this review we present key studies on how technology is practically used to treat cognitive defic…
View article: S56. PHOENIX GROUP, A PROJECT TO PREVENT RELAPSES IN SCHIZOPHRENIA
S56. PHOENIX GROUP, A PROJECT TO PREVENT RELAPSES IN SCHIZOPHRENIA Open
BACKGROUND: Schizophrenia is a syndrome of variable and highly disruptive psychopathology that infers emotion, perception, and several aspects of behavior. Relapses caused by noncompliance are common and may lead to hospitalizations. In ma…
View article: O5.5. SLEEP IN MAJOR PSYCHIATRIC DISORDERS: RESULTS FROM NATIONWIDE SUPER FINLAND STUDY
O5.5. SLEEP IN MAJOR PSYCHIATRIC DISORDERS: RESULTS FROM NATIONWIDE SUPER FINLAND STUDY Open
People with psychotic disorders demonstrate a wide spectrum of sleep abnormalities. Abnormalities include changes in total sleep time, increased sleep onset latency, increased wake-up time after sleep onset and abnormalities in sleep archi…
View article: INFLUENCE OF BIRTH WEIGHT ON THE RISK AND CLINICAL PRESENTATION OF SCHIZOPHRENIA
INFLUENCE OF BIRTH WEIGHT ON THE RISK AND CLINICAL PRESENTATION OF SCHIZOPHRENIA Open
Pre- and perinatal environmental factors have been associated with increased schizophrenia risk, particularly in combination with genetic liability. Both low and high birth weight have been associated with an increased risk of autism spect…
View article: An interaction between NDE1 and high birth weight increases schizophrenia susceptibility
An interaction between NDE1 and high birth weight increases schizophrenia susceptibility Open
Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders…