Asma Munir
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View article: Proteoglycan-4 potentiates the antitumor efficacy of regorafenib in an orthotopic model of hepatocellular carcinoma
Proteoglycan-4 potentiates the antitumor efficacy of regorafenib in an orthotopic model of hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) presents a significant therapeutic challenge, as current treatment options provide limited long-term benefits due to issues surrounding their effectiveness and associated adverse effects. Our previ…
View article: ASSOCIATION OF ANEMIA WITH PARITY AMONG PREGNANT MOTHERS
ASSOCIATION OF ANEMIA WITH PARITY AMONG PREGNANT MOTHERS Open
Background: Iron deficiency, a major preventable cause of anemia globally, is a significant public health challenge in South Asia, particularly in Peshawar, affecting a significant portion of the population. Objective: To determine the inc…
View article: Clinical management and outcomes of snake envenomation: a case series: Snake Envenomation: A Case Series
Clinical management and outcomes of snake envenomation: a case series: Snake Envenomation: A Case Series Open
Introduction. In tropical rural communities, snakebite envenomation is among the main causes of morbidity and mortality. It results in shock, hemorrhage, tissue necrosis, and swelling. Diagnosing and identifying snake species is challengin…
View article: The Effectiveness of Different Volumes of Articaine for Inferior Alveolar Nerve Block for Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis
The Effectiveness of Different Volumes of Articaine for Inferior Alveolar Nerve Block for Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis Open
Objective: To compare the efficacy of 3.6ml Vs 1.8ml articaine concentrations for lower alveolar nerve blocks with symptomatic irreversible pulpitis. Study Design: Quasi experimental study Place and Duration of Study: Operative Dentistry D…
View article: Aldosterone-to-Renin Ratio as a Diagnostic and Prognostic Marker in Resistant Hypertension: Insights from a Retrospective Observational Study on Age, Hormonal Dysregulation, and Anthropometric Correlates
Aldosterone-to-Renin Ratio as a Diagnostic and Prognostic Marker in Resistant Hypertension: Insights from a Retrospective Observational Study on Age, Hormonal Dysregulation, and Anthropometric Correlates Open
Resistant hypertension (RH) presents a significant clinical challenge, often requiring multi-faceted management strategies. This study aimed to evaluate the utility of the Aldosterone-to-Renin Ratio (ARR) as a diagnostic tool in identifyin…
View article: Diagnostic Potential of Haematological Indices (Mentzer Index and RDWI) to Distinguish Iron Deficiency Anemia and βTT
Diagnostic Potential of Haematological Indices (Mentzer Index and RDWI) to Distinguish Iron Deficiency Anemia and βTT Open
Background: Iron Deficiency Anemia (IDA) and β-thalassemia trait (βTT) are the most frequently encountered entities presenting with microcytic hypochromic anemia. It is essential to distinguish between IDA and βTT to avoid incorrect diagno…
View article: Role of Arbuscular Mycorrhizal Fungi in Regulating Growth, Enhancing Productivity, and Potentially Influencing Ecosystems under Abiotic and Biotic Stresses
Role of Arbuscular Mycorrhizal Fungi in Regulating Growth, Enhancing Productivity, and Potentially Influencing Ecosystems under Abiotic and Biotic Stresses Open
Arbuscular mycorrhizal fungi (AMF) form symbiotic relationships with the roots of nearly all land-dwelling plants, increasing growth and productivity, especially during abiotic stress. AMF improves plant development by improving nutrient a…
View article: Immuno-affinity chromatography for purification of IgG from hyper-immune sera raised against 146S fraction of Foot and Mouth Disease Virus for diagnostic purposes
Immuno-affinity chromatography for purification of IgG from hyper-immune sera raised against 146S fraction of Foot and Mouth Disease Virus for diagnostic purposes Open
Immunoaffinity chromatography (IAC) is a fundamental isolation and purification tool which is incorporated in a substantial range of therapeutic and diagnostic applications. This study has reappraised the usefulness of immunoaffinity chrom…
View article: Abstract P4-07-57: Outcomes of Triple-Negative Breast Cancer In Older Versus Younger Women
Abstract P4-07-57: Outcomes of Triple-Negative Breast Cancer In Older Versus Younger Women Open
Background: Triple-negative breast cancer (TNBC) is an aggressive disease characterized by lack of targeted therapy; main-stay of treatment being limited to surgery and chemotherapy. Older patients with TNBC are often underrepresented in t…
View article: Evolutionary dynamics of topotype ME-SA/Ind-2001 of foot and mouth disease virus serotype-O in Pakistan: 2017-2022.
Evolutionary dynamics of topotype ME-SA/Ind-2001 of foot and mouth disease virus serotype-O in Pakistan: 2017-2022. Open
Observed mutations suggest potential challenges to current vaccination efficacy against FMD. This emphasizes enhanced FMD surveillance and demonstrates that tracking the emergence of the O/ME-SA/Ind-2001e lineage is important for determini…
View article: Perception regarding the management of defective composite restorations in dental colleges of Pakistan: Repair versus Replacement; a Cross-sectional study
Perception regarding the management of defective composite restorations in dental colleges of Pakistan: Repair versus Replacement; a Cross-sectional study Open
Minimal intervention dentistry (MID) has shifted the trend towards repairing rather than replacing direct composite restorations in case already existing restoration becomes defective.Repairing these restorations has many benefits, such as…
View article: A Comparison Between AH 26 and Sealapex for Post-Obturation Pain
A Comparison Between AH 26 and Sealapex for Post-Obturation Pain Open
Objective: To find out the post-obturation pain with Sealapex and AH26 Sealers on the first, third and seventh day.
Study Design: Quasi-experimental study.
Place and Duration of Study: Armed Forces Institute of Dentistry, Rawalpindi Paki…
View article: A 10 year service evaluation of the survival of 439 patients with early oestrogen receptor positive breast cancer who underwent initial OncotypeDX ® testing to guide adjuvant chemotherapy decisions
A 10 year service evaluation of the survival of 439 patients with early oestrogen receptor positive breast cancer who underwent initial OncotypeDX ® testing to guide adjuvant chemotherapy decisions Open
Use of Oncotype DX RS does guide the treatment decisions and correlates with the BCSS and disease-free survival for ER positive, Her2 negative, early-stage, node negative breast cancer patients.
View article: Geriatric assessment tool application in treatment recommendations for older women with breast cancer
Geriatric assessment tool application in treatment recommendations for older women with breast cancer Open
The results of this study of breast cancer patients aged 65 and above suggest that a self-administered geriatric assessment may influence treatment recommendations in a subset of patients. Recommendations that were influenced by the geriat…
View article: Supplementary Material for: Evaluation of the Effect of Axillary Radiotherapy Dose and the Development of Lymphedema in Breast Cancer Patients
Supplementary Material for: Evaluation of the Effect of Axillary Radiotherapy Dose and the Development of Lymphedema in Breast Cancer Patients Open
Purpose: The present study is aiming to correlate between different radiotherapy techniques, fractionations and doses received by each axillary LN level and axillary vessels with the development of breast cancer related lymphedema (BCRL). …
View article: Automated Breast Volume Assessment Derived From Digital Breast Tomosynthesis Images Compared to Mastectomy Specimen Weight and Its Applications in Cosmetic Optimisation
Automated Breast Volume Assessment Derived From Digital Breast Tomosynthesis Images Compared to Mastectomy Specimen Weight and Its Applications in Cosmetic Optimisation Open
The automated DBT-derived breast volume using the Quantra software is a simple and practical method to assess breast size and weight preoperatively.
View article: Investigating the impacts of resistance mutations in Mycobacterium tuberculosis in order to improve the selection of new drug targets
Investigating the impacts of resistance mutations in Mycobacterium tuberculosis in order to improve the selection of new drug targets Open
Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis (M. tb). There is an urgent need to understand the mechanism by which the …
View article: Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis
Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis Open
Resolution advances in cryoelectron microscopy (cryo-EM) now offer the possibility to visualize structural effects of naturally occurring resistance mutations in proteins and also of understanding the binding mechanisms of small drug molec…
View article: Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance Open
Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines presents m…
View article: Frequency and Types of Red Cell Alloantibodies in Pregnant Females
Frequency and Types of Red Cell Alloantibodies in Pregnant Females Open
Introduction: Maternal isoimmunization, also called alloimmunization, occurs when immune system of a pregnant female is sensitized to foreign RBC surface antigen producing immune process. This maternal blood when goes to fetal circulation,…
View article: Analysis of metabolic pathways in mycobacteria to aid drug-target identification
Analysis of metabolic pathways in mycobacteria to aid drug-target identification Open
Three related mycobacteria are the cause of widespread infections in man and are the focus of intense research and drug-discovery efforts in the face of growing antimicrobial resistance. Mycobacterium tuberculosis , the causative agent of …