Asma Fikree
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View article: Finding the Line Between Avoidant/Restrictive Food Intake Disorder and Refractory Disorders of Gut–Brain Interaction Using Lenient vs. Strict Severity Criteria: A Retrospective Exploratory Analysis From a Single Tertiary Neurogastroenterology Centre
Finding the Line Between Avoidant/Restrictive Food Intake Disorder and Refractory Disorders of Gut–Brain Interaction Using Lenient vs. Strict Severity Criteria: A Retrospective Exploratory Analysis From a Single Tertiary Neurogastroenterology Centre Open
Background Avoidant/restrictive food intake disorder (ARFID) is common among adults with disorders of gut–brain interaction (DGBI) presenting to gastroenterology settings. Symptoms overlap between ARFID and DGBI. How the severity of ARFID …
View article: Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initial nurse-led management
Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initial nurse-led management Open
Objective Many people with inflammatory bowel disease (IBD) experience fatigue, pain and faecal incontinence that some feel are inadequately addressed. It is unknown how many have potentially reversible medical issues underlying these symp…
View article: A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life
A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life Open
BACKGROUND: A high prevalence of disorders of gut-brain interaction (DGBI) exist in patients with hypermobile Ehlers-Danlos Syndrome (hEDS) and hypermobility spectrum disorders (HSD). However, it is unknown if clusters of hEDS/HSD patients…
View article: A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life
A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life Open
Background A high prevalence of disorders of gut‐brain interaction (DGBI) exist in patients with hypermobile Ehlers‐Danlos Syndrome (hEDS) and hypermobility spectrum disorders (HSD). However, it is unknown if clusters of hEDS/HSD patients …
View article: Editorial: rectal hyposensitivity in patients with hypermobile <scp>E</scp>hlers‐<scp>D</scp>anlos syndrome and constipation—authors' reply
Editorial: rectal hyposensitivity in patients with hypermobile <span>E</span>hlers‐<span>D</span>anlos syndrome and constipation—authors' reply Open
LINKED CONTENT This article is linked to Choudhary et al papers. To view these articles, visit https://doi.org/10.1111/apt.17104 and https://doi.org/10.1111/apt.17134
View article: Rectal hyposensitivity: a common pathophysiological finding in patients with constipation and associated hypermobile Ehlers–Danlos syndrome
Rectal hyposensitivity: a common pathophysiological finding in patients with constipation and associated hypermobile Ehlers–Danlos syndrome Open
Summary Background and Aims To evaluate symptom presentation and underlying pathophysiology of colonic/anorectal dysfunction in females with functional constipation (FC) and hypermobile Ehlers–Danlos syndrome (hEDS)/hypermobility spectrum …
View article: Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management
Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management Open
Patients diagnosed with hypermobile Ehlers-Danlos syndrome and hypermobile spectrum disorders are increasingly presenting to secondary and tertiary care centres with gastrointestinal (GI) symptoms and nutritional issues. Due to the absence…
View article: PWE-60 Undiagnosed psychopathology is prevalent and significant in patients attending a tertiary neurogastroenterology clinic
PWE-60 Undiagnosed psychopathology is prevalent and significant in patients attending a tertiary neurogastroenterology clinic Open
Introduction According to the biopsychosocial model for functional gastrointestinal (GI) disorders, the presence of psychopathology influences symptom presentation and should be targeted in the management plan. We aimed to determine what p…
View article: PWE-66 Comorbid Irritable Bowel Syndrome and Hypermobile Ehlers-Danlos Syndrome: A distinct clinical phenotype?
PWE-66 Comorbid Irritable Bowel Syndrome and Hypermobile Ehlers-Danlos Syndrome: A distinct clinical phenotype? Open
Introduction Several studies have demonstrated a high prevalence of Functional Gastrointestinal Disorders (FGID), particularly irritable bowel syndrome (IBS) in patients with Hypermobile Ehlers-Danlos Syndrome (hEDS) and hypermobility spec…
View article: O60 Altered colonic neuroinflammatory profile in irritable bowel syndrome with and without hypermobile ehlers danlos syndrome
O60 Altered colonic neuroinflammatory profile in irritable bowel syndrome with and without hypermobile ehlers danlos syndrome Open
Introduction Hypermobile Ehlers-Danlos syndrome (hEDS), characterized by skin hyperextensibility, tissue fragility and joint hypermobility, is associated with features consistent with irritable bowel syndrome (IBS) (Nelson at al 2015, Zeit…
View article: Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation
Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation Open
BACKGROUND Chronic constipation is a prevalent disorder that affects patients' quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are un…
View article: Joint Hypermobility Syndrome in Patients With Functional Dyspepsia
Joint Hypermobility Syndrome in Patients With Functional Dyspepsia Open
INTRODUCTION: The pathophysiology underlying functional dyspepsia (FD) is multifactorial and focuses on gastric sensorimotor dysfunction. Recent studies demonstrated that joint hypermobility syndrome (JHS) is strongly associated with unexp…
View article: Colonoscopy is safe and not associated with higher pain scores in patients with hypermobility spectrum disorder: results from an exploratory prospective study
Colonoscopy is safe and not associated with higher pain scores in patients with hypermobility spectrum disorder: results from an exploratory prospective study Open
Background: Patient perception of colonoscopy varies greatly. Young slender women and patients with irritable bowel syndrome (IBS) appear to be at risk for periprocedural pain. Recent evidence suggests a high prevalence of joint hypermobil…
View article: Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance
Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance Open
This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small b…
View article: A novel role for the extracellular matrix glycoprotein‐Tenascin‐X in gastric function
A novel role for the extracellular matrix glycoprotein‐Tenascin‐X in gastric function Open
Key points Tenascin X (TNX) functions in the extracellular matrix of skin and joints where it maintains correct intercellular connections and tissue architecture TNX is associated exclusively with vagal‐afferent endings and some myenteric …
View article: The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones
The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones Open
Key points Tenascin‐X (TNX) is an extracellular matrix glycoprotein with anti‐adhesive properties in skin and joints. Here we report the novel finding that TNX is expressed in human and mouse gut tissue where it is exclusive to specific su…
View article: A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers‐Danlos Syndrome‐Hypermobility Type: A feasibility study
A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers‐Danlos Syndrome‐Hypermobility Type: A feasibility study Open
Background The clinical use of Magnetic Resonance Imaging ( MRI ) for investigating gastric motor function in dyspepsia is limited, largely due to protocol complexity, cost and limited availability. In this study, we explore the feasibilit…
View article: Gastrointestinal involvement in the Ehlers–Danlos syndromes
Gastrointestinal involvement in the Ehlers–Danlos syndromes Open
Current evidence suggests that an association exists between non‐inflammatory hereditary disorders of connective tissue such as the Ehlers–Danlos syndromes (EDS) and gastrointestinal (GI) symptoms. Patients with EDS can present with both s…
View article: Gastrointestinal disorders in joint hypermobility syndrome/Ehlers‐Danlos syndrome hypermobility type: A review for the gastroenterologist
Gastrointestinal disorders in joint hypermobility syndrome/Ehlers‐Danlos syndrome hypermobility type: A review for the gastroenterologist Open
Background Joint hypermobility syndrome ( JHS )/Ehlers‐Danlos syndrome hypermobility type ( EDS ‐ HT ) is the most common hereditary non‐inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hy…