Abida Raza
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View article: Synthesis, structural characterization, and antitumor effect of quercetin-loaded chitosan nanoparticles-stabilized pickering emulsion via suppressing the PI3K/AKT/mTOR signaling pathway
Synthesis, structural characterization, and antitumor effect of quercetin-loaded chitosan nanoparticles-stabilized pickering emulsion via suppressing the PI3K/AKT/mTOR signaling pathway Open
Quercetin, a major polyphenolic flavonoid phytoconstituent, exhibits diverse pharmacological activities, including antiviral, antimicrobial, anticancer, and anti-inflammatory effects, and is used in the treatment of metabolic and allergic …
View article: Comparative analysis of plasma betatrophin levels with placental dysfunction in preeclamptic pregnancies: A histopathological and biochemical study
Comparative analysis of plasma betatrophin levels with placental dysfunction in preeclamptic pregnancies: A histopathological and biochemical study Open
Objective: This study compared plasma betatrophin levels and placental morphological and histopathological changes between preeclamptic and normotensive pregnancies. Material and Methods: This cross-sectional study included 90 pregnant wom…
View article: Development of chitosan colistin nano-antibiotics and its in-vitro activity against multidrug resistant Acinetobacter baumannii
Development of chitosan colistin nano-antibiotics and its in-vitro activity against multidrug resistant Acinetobacter baumannii Open
Gram-negative bacteria are resistant to different antibiotics and thus they are the culprits of serious infections in hospitals. Colistin can be considered at least the possible antibiotic against these microorganisms. In this study, Colis…
View article: Fungus-mediated synthesis of Se-BiO-CuO multimetallic nanoparticles as a potential alternative antimicrobial against ESBL-producing Escherichia coli of veterinary origin
Fungus-mediated synthesis of Se-BiO-CuO multimetallic nanoparticles as a potential alternative antimicrobial against ESBL-producing Escherichia coli of veterinary origin Open
Bacterial infections emerge as a significant contributor to mortality and morbidity worldwide. Emerging extended-spectrum β-lactamase (ESBL) Escherichia coli strains provide a greater risk of bacteremia and mortality, are increasingly resi…
View article: Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice
Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice Open
The potential of levosulpiride-loaded nanostructured lipid carriers (LSP-NLCs) for enhanced antidepressant and anxiolytic effects was evaluated in the current study. A forced swim test (FST) and tail suspension test (TST) were carried out …
View article: In vitro Anti-Cancer Effect of Polymeric Nanoparticles Encapsulating Caralluma tuberculata in Cancer Cells
In vitro Anti-Cancer Effect of Polymeric Nanoparticles Encapsulating Caralluma tuberculata in Cancer Cells Open
Rapidly evolving drug delivery systems employ therapeutic agents (liposomes, polymers, and nanospheres) to achieve optimum therapeutic and targeted effects with declined side effects to cure chronic diseases like cancer. Nano-formulation o…
View article: Recent Advances in Sorafenib based Nanoformulation for Enhanced Cancer Therapy
Recent Advances in Sorafenib based Nanoformulation for Enhanced Cancer Therapy Open
Sorafenib, a multi-kinase inhibitor has gained significant attention in cancer therapy. However, the clinical use of sorafenib is limited by poor aqueous solubility, low bioavailability, unfavorable pharmacokinetic properties, and undesira…
View article: Wound healing and anti-inflammatory potential of <i>Ajuga bracteosa</i>-conjugated silver nanoparticles in Balb/c mice
Wound healing and anti-inflammatory potential of <i>Ajuga bracteosa</i>-conjugated silver nanoparticles in Balb/c mice Open
Background Wound therapy is complicated, uncomfortable for the patient, and costly for the health-care system. Silver nanoparticles (AgNP) have antibacterial characteristics that can prevent bacterial infection in wounds and speed up wound…
View article: Glycol-Chitosan-Based Technetium-99m-Loaded Multifunctional Nanomicelles: Synthesis, Evaluation, and In Vivo Biodistribution
Glycol-Chitosan-Based Technetium-99m-Loaded Multifunctional Nanomicelles: Synthesis, Evaluation, and In Vivo Biodistribution Open
We hereby propose the use of stable, biocompatible, and uniformly sized polymeric micelles as high-radiotracer-payload carriers at region-of-interest with negligible background activity due to no or low offsite radiolysis. We modified glyc…
View article: Design and Characterization of Paclitaxel-Loaded Polymeric Nanoparticles Decorated With Trastuzumab for the Effective Treatment of Breast Cancer
Design and Characterization of Paclitaxel-Loaded Polymeric Nanoparticles Decorated With Trastuzumab for the Effective Treatment of Breast Cancer Open
The aim of the study was to design and formulate an antibody-mediated targeted, biodegradable polymeric drug delivery system releasing drug in a controlled manner to achieve a therapeutic goal for the effective treatment of breast cancer. …
View article: A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters
A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters Open
P-glycoprotein (P-gP) efflux-mediated multidrug resistance is a fundamental aspect of chemotherapeutic failure in oncology. The current study aims to deliver paclitaxel (PTX) specifically at the target site with improved in vivo efficacy o…
View article: Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii: In silico, in vitro and in vivo Studies
Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii: In silico, in vitro and in vivo Studies Open
Novel mastoparan-loaded chitosan nanoconstructs signify a successful strategy for achieving a synergistic bactericidal effect and higher therapeutic efficacy against MDR clinical A. baumannii isolates. The Mast-Cs nano-drug delivery system…
View article: Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management
Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management Open
Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current study was to fabricate biocompatible multifunctional drug-loaded nanoscale …
View article: Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability
Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability Open
Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissoluti…
View article: Calcium based siRNA coating: a novel approach for knockdown of HER2 gene in MCF-7 cells using gold nanoparticles
Calcium based siRNA coating: a novel approach for knockdown of HER2 gene in MCF-7 cells using gold nanoparticles Open
Surface functionalization of nanoparticles (NPs) for therapeutic siRNA delivery into cancer cells has gained interest. The present study was designed for surface functionalization of gold nanoparticles (AuNPs) for efficient siRNA delivery …
View article: Doxorubicin loaded gold nanorods: a multifunctional chemo-photothermal nano-platform for cancer management
Doxorubicin loaded gold nanorods: a multifunctional chemo-photothermal nano-platform for cancer management Open
One of the limitations associated with cancer treatment is low efficacy and high dose-related side effects of anticancer drugs. The purpose of the current study was to fabricate biocompatible multifunctional drug loaded nano-moieties for c…
View article: Novel Polymorphism in the Promoter Region of HLA-DQB1 Is a Predictor of Anti-HCV Therapy Response
Novel Polymorphism in the Promoter Region of HLA-DQB1 Is a Predictor of Anti-HCV Therapy Response Open
Background: Hepatitis C virus (HCV) is a major cause of chronic liver infection, which may lead to liver cirrhosis, fibrosis, and hepatocellular carcinoma while about one-fourth of the infected patients recover spontaneously. The host immu…
View article: Doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan polymeric nanoformulation: uptake by cells and organs
Doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan polymeric nanoformulation: uptake by cells and organs Open
The features of nanoformulation, ie, small particle size, sustained drug release, and enhanced cellular uptake, potential to target tumor passively coupled with the possibility of monitoring of tumor localization by optical imaging may mak…
View article: Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer’s Disease: Present Status and Future Opportunities
Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer’s Disease: Present Status and Future Opportunities Open
Alzheimer's disease (AD) is characterized by cognitive inability manifested due to the accumulation of β-amyloid, formation of hyper phosphorylated neurofibrillary tangles, and a malfunctioned cholinergic system. The degeneration integrity…
View article: A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan Open
This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in Pakistan. Further studies are needed to understand multidrug-resistant HCV variants in the Pakistani population.
View article: Formal modeling of the key determinants of Hepatitis C Virus (HCV) induced adaptive immune response network: An integrative approach to map the cellular and cytokine-mediated host immune regulations
Formal modeling of the key determinants of Hepatitis C Virus (HCV) induced adaptive immune response network: An integrative approach to map the cellular and cytokine-mediated host immune regulations Open
Background. Hepatitis C Virus (HCV) is a major causative agent of liver infection leading to critical liver damage. In response to HCV, the improper regulation of host immune system leads to chronic infection. The host immune system employ…
View article: Formal modeling of the key determinants of Hepatitis C Virus (HCV) induced adaptive immune response network: An integrative approach to map the cellular and cytokine-mediated host immune regulations
Formal modeling of the key determinants of Hepatitis C Virus (HCV) induced adaptive immune response network: An integrative approach to map the cellular and cytokine-mediated host immune regulations Open
Background. Hepatitis C Virus (HCV) is a major causative agent of liver infection leading to critical liver damage. In response to HCV, the improper regulation of host immune system leads to chronic infection. The host immune system employ…
View article: Stable and reproducible synthesis of gold nanorods for biomedical applications: a comprehensive study
Stable and reproducible synthesis of gold nanorods for biomedical applications: a comprehensive study Open
Gold nanorods (GNRs) are ideal choice in biomedical research due to their amenability of synthesis, tunable plasmonic properties, less toxicity and ease of detection but their diverse biological applications necessitate stable structure. D…
View article: Biofilm reduction, cell proliferation, anthelmintic and cytotoxicity effect of green synthesised silver nanoparticle using <i>Artemisia vulgaris</i> extract
Biofilm reduction, cell proliferation, anthelmintic and cytotoxicity effect of green synthesised silver nanoparticle using <i>Artemisia vulgaris</i> extract Open
Infectious diseases are caused by etiological agents. Nanotechnology has been used to minimise the effect of clinical pathogens which have resistance to antibiotics. In current research synthesis, characterisation and biological activities…