Akshay Sharma
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View article: Impact of Age on Graft-vs-Host Disease and Overall Survival in Pediatric Hematopoietic Cell Transplant Recipients
Impact of Age on Graft-vs-Host Disease and Overall Survival in Pediatric Hematopoietic Cell Transplant Recipients Open
Advances in graft-versus-host disease (GVHD) prevention and treatment have resulted in expanded donor options and improvement in treatment-related mortality (TRM). This analysis aimed to compare the incidence of acute and chronic GVHD (aGV…
View article: Pulmonary Hypertension in Rare Disease Overlap: Neurofibromatosis Type 1 Meets Sarcoidosis
Pulmonary Hypertension in Rare Disease Overlap: Neurofibromatosis Type 1 Meets Sarcoidosis Open
View article: Implementation of an Early Mobility Initiative in a Pediatric Bone Marrow Transplant Unit
Implementation of an Early Mobility Initiative in a Pediatric Bone Marrow Transplant Unit Open
Background/Objectives: Children who have received hematopoietic cell transplants (HCTs) often face complex clinical courses and complications that increase their risk of functional impairments. Because of this, pediatric HCT recipients may…
View article: Long-term follow-up demonstrates durable clinical benefits of exagamglogene autotemcel for sickle cell disease with recurrent vaso-occlusive crises: Final results of climb SCD-121
Long-term follow-up demonstrates durable clinical benefits of exagamglogene autotemcel for sickle cell disease with recurrent vaso-occlusive crises: Final results of climb SCD-121 Open
Background: Exagamglogene autotemcel (exa-cel) is a one-time, ex vivo CRISPR/Cas9 gene-edited, autologous cell therapy approved for patients ≥12 years old with severe sickle cell disease (SCD). We report results for durable, long-term effi…
View article: Donor lymphocyte infusions after HCT are associated with low risk of graft-versus-host disease in pediatric and young adult patients
Donor lymphocyte infusions after HCT are associated with low risk of graft-versus-host disease in pediatric and young adult patients Open
View article: Author response: Telomeres control human telomerase (TERT) expression through non-telomeric TRF2
Author response: Telomeres control human telomerase (TERT) expression through non-telomeric TRF2 Open
View article: Telomeres control human telomerase (TERT) expression through non-telomeric TRF2
Telomeres control human telomerase (TERT) expression through non-telomeric TRF2 Open
The function of the human telomerase reverse transcriptase (referred hereafter as TERT ) in the synthesis and maintenance of chromosome ends, or telomeres, is widely understood. Whether and how telomeres, on the other hand, influence TERT …
View article: NFATc1 drives Orai3 transcription and proteolysis by harnessing epigenome differences in the MARCH8 promoter
NFATc1 drives Orai3 transcription and proteolysis by harnessing epigenome differences in the MARCH8 promoter Open
Several autonomous mechanisms regulate protein expression, such as transcription, translation, post-translational modifications, and epigenetic changes. Rarely, these processes are controlled by the same molecular player with overlapping r…
View article: Population Health Research in Medical Education Addresses California Central Valley Health Disparities
Population Health Research in Medical Education Addresses California Central Valley Health Disparities Open
Background California's Central Valley faces severe health disparities exacerbated by poverty, provider shortages, and cultural barriers. The Physician's Role in the Health System (PRHS) course at California Health Sciences University Coll…
View article: Improvements in health-related quality of life in patients with severe sickle cell disease after exagamglogene autotemcel
Improvements in health-related quality of life in patients with severe sickle cell disease after exagamglogene autotemcel Open
Severe sickle cell disease (SCD), an inherited blood disorder characterized by recurrent vaso-occlusive crises (VOCs), significantly impairs health-related quality of life (HRQoL). Exagamglogene autotemcel (exa-cel), a one-time, ex vivo CR…
View article: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2
Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2 Open
The function of the human telomerase reverse transcriptase (hTERT) in the synthesis and maintenance of chromosome ends, or telomeres, is widely understood. Whether and how telomeres, on the other hand, influence hTERT regulation is relativ…
View article: Author response: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2
Author response: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2 Open
View article: Impact of Race and Ethnicity on Outcomes after Umbilical Cord Blood Transplantation
Impact of Race and Ethnicity on Outcomes after Umbilical Cord Blood Transplantation Open
View article: Right Dorso-Caudal Flank Laparohysterotomy to Manage Prolonged Macerated Fetal Retention in a Cow
Right Dorso-Caudal Flank Laparohysterotomy to Manage Prolonged Macerated Fetal Retention in a Cow Open
A six-year-old pluriparous cow was presented with a history of retained macerated fetus for 99 days. Due to the pelvic location of the uterus, surgical exteriorisation was done through right dorso-caudal flank. Bunch of fetal bones, with 2…
View article: ALZHEIMERS DISEASE: FROM CLINICAL PRESENTATION TO THERAPEUTIC STRATEGIES
ALZHEIMERS DISEASE: FROM CLINICAL PRESENTATION TO THERAPEUTIC STRATEGIES Open
Alzheimers disease (AD) is the most common form of dementia, primarily affecting individuals over the age of 65. It is a progressive neurodegenerative disorder that impairs memory, cognition, language, and decision-making abilities. AD pro…
View article: Normalization of Cerebral Hemodynamics After Gene Therapy in Adults With Sickle Cell Disease
Normalization of Cerebral Hemodynamics After Gene Therapy in Adults With Sickle Cell Disease Open
No abstract
View article: New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care
New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care Open
Extra Corporeal Life Support (ECLS) for pediatric oncology and stem cell transplant patients over the past two decades has made progress. Substantial improvements in ECLS, Continuous Renal Replacement Therapy (CRRT), and mechanical ventila…
View article: To pursue gene therapy or not? Is it feasible after graft failure in allogeneic hematopoietic cell transplant recipients
To pursue gene therapy or not? Is it feasible after graft failure in allogeneic hematopoietic cell transplant recipients Open
Two autologous hematopoietic stem cell (HSC)–based gene therapies (GTs) are now commercially available for severe sickle cell disease and transfusion-dependent β-thalassemia. However, the safety and efficacy of a subsequent autologous HSC-…
View article: HLA antibodies delay platelet recovery after gene therapy
HLA antibodies delay platelet recovery after gene therapy Open
View article: Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study
Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study Open
Background In this study, we compared outcomes of intensified myeloablative conditioning regimens using large registry data from Japan (Japanese Society for Transplantation and Cellular Therapy) and the United States (Center for Internatio…
View article: Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR
Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR Open
Infection is increasingly recognized as a significant cause of morbidity and mortality in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) receiving CD19 chimeric antigen receptor (CAR) T-cell therapy. The current study…
View article: Carboxyl Terminal Domain Missense Mutations Alter Distinct Gating Properties of the Cardiac Sodium Channel
Carboxyl Terminal Domain Missense Mutations Alter Distinct Gating Properties of the Cardiac Sodium Channel Open
Voltage-gated sodium channels undergo reversible voltage/time-dependent transitions from closed to open and inactivated states. The voltage setpoints and efficiency of cardiac sodium channel Na v 1.5 state transitions are crucial for tunin…
View article: Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study
Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study Open
View article: Telomeres control human telomerase (TERT) expression through non-telomeric TRF2
Telomeres control human telomerase (TERT) expression through non-telomeric TRF2 Open
The function of the human telomerase reverse transcriptase (referred hereafter as TERT ) in the synthesis and maintenance of chromosome ends, or telomeres, is widely understood. Whether and how telomeres, on the other hand, influence TERT …
View article: Author response: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2
Author response: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2 Open
View article: Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2
Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2 Open
The function of the human telomerase reverse transcriptase (hTERT) in the synthesis and maintenance of chromosome ends, or telomeres, is widely understood. Whether and how telomeres, on the other hand, influence hTERT regulation is relativ…
View article: Beyond the traditional oncology patient: the role of palliative care in patients with sickle cell disease receiving stem cell transplantation or gene therapy
Beyond the traditional oncology patient: the role of palliative care in patients with sickle cell disease receiving stem cell transplantation or gene therapy Open
People with severe sickle cell disease (SCD) are now presented with increasing access to curative-intent therapies including allogeneic hematopoietic stem cell transplantation (HCT) and gene therapy (GT). These high-risk, high-reward thera…
View article: Senolytics restore hematopoietic stem cell function in sickle cell disease
Senolytics restore hematopoietic stem cell function in sickle cell disease Open
Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) dysfunction, possibly due to pathologic…
View article: NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape
NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape Open
The functional significance of any protein in physiological processes and pathological conditions is largely dependent on its expression profile. Therefore, nature has evolved several autonomous mechanisms to regulate protein expression su…
View article: Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments
Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments Open
Mitochondria regulate several physiological functions through mitochondrial Ca 2+ dynamics. However, role of mitochondrial Ca 2+ signaling in melanosome biology remains unknown. Here, we show that pigmentation requires mitochondrial Ca 2+ …