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View article: Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis
Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis Open
Vγ9Vδ2T cells have the unique ability to recognize a broad range of malignant transformed cells. The tumor targeting event involving BTN2A1 and BTN3A1 dimers on the tumor cell surface is critical, leading to full activation of the TCR. Alt…
View article: Uncovering the mode of action of engineered T cells in patient cancer organoids
Uncovering the mode of action of engineered T cells in patient cancer organoids Open
Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal therapeutic modes of action at the molecular level. Here we describe a system, called BE…
View article: Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids Open
Summary Cellular immunotherapies are rapidly gaining clinical importance, yet predictive platforms for modeling their mode of action are lacking. Here, we developed a dynamic immuno-organoid 3D imaging-transcriptomics platform; BEHAV3D, to…
View article: RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor
RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor Open