Astrid Wietelmann
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View article: Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice
Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice Open
Aims: The aim of the present study was to investigate the inhibition of classically activated macrophages in myocardial infarction (MI) under the influence of the chemokine (C‐C motif) receptor 2 (CCR2) antagonist propagermanium (PPG). Met…
View article: Targeting ADORA-PDE10 cAMP Microdomain: A Novel Therapeutic Approach for Pulmonary Hypertension
Targeting ADORA-PDE10 cAMP Microdomain: A Novel Therapeutic Approach for Pulmonary Hypertension Open
Summary Despite substantial advancements in the treatment of pulmonary arterial hypertension (PAH), obstacles remain in achieving optimal outcomes. In this study, we focus on understanding the therapeutic effect of targeting the ADORA1/PDE…
View article: Inhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts
Inhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts Open
The HSP70 co-chaperone BAG3 targets unfolded proteins to degradation via chaperone assisted selective autophagy (CASA), thereby playing pivotal roles in the proteostasis of adult cardiomyocytes (CMs). However, the complex functions of BAG3…
View article: Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models
Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models Open
View article: Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation
Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation Open
Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/N…
View article: Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation
Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation Open
Supplementary text, tables and figures
View article: Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation
Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation Open
Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/N…
View article: Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation
Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation Open
Supplementary text, tables and figures
View article: Publisher Correction: Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Publisher Correction: Inhibition of fatty acid oxidation enables heart regeneration in adult mice Open
View article: Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Inhibition of fatty acid oxidation enables heart regeneration in adult mice Open
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration 1,2 . Here, to …
View article: Comparison of edoxaban and enoxaparin in a rat model of AlCl3-induced thrombosis of the superior sagittal sinus
Comparison of edoxaban and enoxaparin in a rat model of AlCl3-induced thrombosis of the superior sagittal sinus Open
View article: The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation Open
Immune cell trafficking constitutes a fundamental component of immunological response to tissue injury, but the contribution of intrinsic RNA nucleotide modifications to this response remains elusive. We report that RNA editor ADAR2 exerts…
View article: Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling Open
Background: The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments available to prevent RV fail…
View article: Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 Open
View article: ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7
ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7 Open
Background: ADAR1 (adenosine deaminase acting on RNA-1)-mediated adenosine to inosine (A-to-I) RNA editing plays an essential role for distinguishing endogenous from exogenous RNAs, preventing autoinflammatory ADAR1 also regulates cellular…
View article: Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice
Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice Open
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) signaling protects the heart after myocardial infarction (MI). In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the re…
View article: Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish
Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish Open
Aims Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a…
View article: Microbubble-mediated sonothrombolysis with BR38 of a venous full blood thrombus in a rat embolic stroke model
Microbubble-mediated sonothrombolysis with BR38 of a venous full blood thrombus in a rat embolic stroke model Open
Our study showed the efficacy and safety of mmSTL with or without rt-PA in an embolic rat stroke model using a continuous full blood thrombus. Sonothrombolysis might be useful for patients who need to be transported to a thrombectomy centr…
View article: Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation
Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation Open
Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/N…
View article: Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish
Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish Open
Mammalian models have been instrumental to investigate adult heart function and human disease. However, electrophysiological differences with human hearts and high costs emphasize the need for additional models. The zebrafish is a well-est…
View article: Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction Open
View article: Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome Open
View article: Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance
Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance Open
Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myo…
View article: Author response: Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance
Author response: Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Myogenic vasoconstriction is an autoregula…
View article: Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy
Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy Open
View article: A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension Open
View article: Response to: Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”
Response to: Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding” Open
View article: Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding
Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding Open
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by remodeling of the pulmonary vasculature and a rise in right ventricular (RV) afterload. The increased RV afterload leads to right ventricular failure (RVF) wh…
View article: Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1
Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1 Open
Significance This paper describes a mechanism of regulation of Sirt1 activity by Sirt7. Deacetylases Sirt1 and Sirt7 belong to the mammalian family of seven sirtuins, which play important regulatory roles in several biological processes su…
View article: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)
Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4) Open
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While l…