Asuka Katsuki
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View article: Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study
Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study Open
Background Cognitive impairment is common in people with mental disorders, leading to transdiagnostic classification based on cognitive characteristics. However, few studies have used this approach for intellectual abilities and functional…
View article: Pre-treatment plasma cytokine levels as potential predictors of short-term remission of depression
Pre-treatment plasma cytokine levels as potential predictors of short-term remission of depression Open
The response to antidepressants varies significantly among individuals and is difficult to predict before treatment. In this randomised control trial, we explored cytokines that correlate with the therapeutic effect of mirtazapine (MIR) an…
View article: Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus
Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus Open
Introduction Conventional treatment guidelines of schizophrenia do not necessarily provide solutions on clinically important issues. Methods A total of 141 certified psychiatrists of the Japanese Society of Clinical Neuropsychopharmacology…
View article: Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study
Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study Open
Higher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. T…
View article: The brain-derived neurotrophic factor Val66Met polymorphism increases segregation of structural correlation networks in healthy adult brains
The brain-derived neurotrophic factor Val66Met polymorphism increases segregation of structural correlation networks in healthy adult brains Open
Background Although structural correlation network (SCN) analysis is an approach to evaluate brain networks, the neurobiological interpretation of SCNs is still problematic. Brain-derived neurotrophic factor (BDNF) is well-established as a…
View article: Peer Review #1 of "The brain-derived neurotrophic factor Val66Met polymorphism increases segregation of structural correlation networks in healthy adult brains (v0.2)"
Peer Review #1 of "The brain-derived neurotrophic factor Val66Met polymorphism increases segregation of structural correlation networks in healthy adult brains (v0.2)" Open
Background.Although structural correlation network (SCN) analysis is an approach to evaluate brain networks, the neurobiological interpretation of SCNs is still problematic.Brain-derived neurotrophic factor (BDNF) is well-established as a …
View article: Pharmacological management of bipolar disorder: Japanese expert consensus
Pharmacological management of bipolar disorder: Japanese expert consensus Open
Objectives The aim of this study was to develop a consensus guideline by certified experts of the Japanese Society of Clinical Neuropsychopharmacology on the psychopharmacological treatment for bipolar disorders I and II (BP‐I and BP‐II), …
View article: Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder
Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder Open
Objective: Hippocampal volume is reduced in patients with major depressive disorder (MDD) compared with healthy controls. The hippocampus is a limbic structure that has a critical role in MDD. The aim of the present study was to investigat…
View article: A refractory case of a male patient with neuropsychiatric systemic lupus erythematosus with various psychiatric symptoms and MRI observations
A refractory case of a male patient with neuropsychiatric systemic lupus erythematosus with various psychiatric symptoms and MRI observations Open
Patients with neuropsychiatric systemic lupus erythematosus (NPSLE) frequently show neurological and psychiatric symptoms. When NPSLE is comorbid with a psychiatric disorder, symptoms often overlap leading to a delayed NPSLE diagnosis. Her…
View article: Hippocampal Network Abnormality in Major Depressive Disorder [Presidential Award Proceedings]
Hippocampal Network Abnormality in Major Depressive Disorder [Presidential Award Proceedings] Open
The evaluation of the networks within the hippocampus with magnetic resonance imaging is challenging. We evaluated the hippocampal networks in patients with major depressive disorder (MDD) and healthy participants in this study. We evaluat…
View article: Pharmacological management of depression: Japanese expert consensus
Pharmacological management of depression: Japanese expert consensus Open
Recommendations made by experts in the field are useful and can supplement guidelines and informed decision making in real-world clinical practice. We suggest that pharmacological strategies for depression be flexible and that each patient…
View article: Risk factors for further sick leave among Japanese workers returning to work after an episode of major depressive disorder: a prospective follow-up study over 1 year
Risk factors for further sick leave among Japanese workers returning to work after an episode of major depressive disorder: a prospective follow-up study over 1 year Open
Objectives We aimed to investigate the risk factors for further sick leave episodes among Japanese workers returning to work after time off with a major depressive disorder. Design A prospective study with 1 year of follow-up. Participants…
View article: <p>A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorder</p>
A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorder Open
We found that a RERE gene SNP was associated with cortical thickness reductions in the right-lateral orbitofrontal and postcentral lobes in drug-naïve patients with MDD. The effects of RERE gene polymorphism and gene-environment interactio…
View article: <p>COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder</p>
COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder Open
Purpose: Compared with healthy subjects (HS), patients with major depressive disorder (MDD) exhibit volume differences that affect the volume changes in several areas such as the limbic, cortical, subcortical, and white matter. Catechol-O-…
View article: <p>Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms</p>
Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms Open
The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene-environment interacti…
View article: Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study
Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study Open
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View article: Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics
Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics Open
Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first …
View article: Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry Open
There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of pat…
View article: The Impact of Aging, Psychotic Symptoms, Medication, and Brain-Derived Neurotrophic Factor on Cognitive Impairment in Japanese Chronic Schizophrenia Patients
The Impact of Aging, Psychotic Symptoms, Medication, and Brain-Derived Neurotrophic Factor on Cognitive Impairment in Japanese Chronic Schizophrenia Patients Open
Background: Cognitive impairment in schizophrenia can result in considerable difficulty in performing functions of daily life or social rehabilitation. Cognitive impairment in schizophrenia is related to various factors, such as the psycho…
View article: Effects of Continuing Oral Risperidone vs. Switching from Risperidone to Risperidone Long-Acting Injection on Cognitive Function in Stable Schizophrenia Patients: A Pilot Study
Effects of Continuing Oral Risperidone vs. Switching from Risperidone to Risperidone Long-Acting Injection on Cognitive Function in Stable Schizophrenia Patients: A Pilot Study Open
The results of this preliminary study suggest that switching from oral risperidone to RLAI may improve verbal capability more than continuing with oral risperidone. However, these findings must be replicated in a larger, double-blind study.
View article: Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study
Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study Open
The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.
View article: Do Benzodiazepines Plus Fluvoxamine Cause a Rapid Increase in Serum Brain-derived Neurotrophic Factor or Clinical Improvement in Major Depressive Disorder Patients?
Do Benzodiazepines Plus Fluvoxamine Cause a Rapid Increase in Serum Brain-derived Neurotrophic Factor or Clinical Improvement in Major Depressive Disorder Patients? Open
Objective: Benzodiazepines are sometimes co-prescribed with antidepressants for patients with major depressive disorder (MDD) who have symptoms such as sleep disturbance, restlessness, or anxiety. The aim of the present study was to examin…
View article: Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia
Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia Open
Aripiprazole has been reported to exert variable effects on cognitive function in patients with schizophrenia. Therefore, in the present study, we evaluated biological markers, clinical data, and psychiatric symptoms in order to identify f…
View article: Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder
Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder Open
Effect of fluvoxamine on IL-6 is partially associated with its clinical efficacy for MDD.