Aswanth Reddy
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View article: Comparative efficacy of complement inhibitors in complement Inhibitor–Naïve PNH: A network meta-analysis of randomized trials
Comparative efficacy of complement inhibitors in complement Inhibitor–Naïve PNH: A network meta-analysis of randomized trials Open
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon, life-threatening disease, caused by intravascular hemolysis by the complement system. The management plan focuses on complement inhibition but, no randomized trial had…
View article: Efficacy, quality of life, and safety of non-clotting factor prophylaxis in Hemophilia A and b: A meta-analysis across inhibitor status
Efficacy, quality of life, and safety of non-clotting factor prophylaxis in Hemophilia A and b: A meta-analysis across inhibitor status Open
Introduction: Hemophilia A and B are among the most common inherited bleeding disorders in humans with lifelong risk of spontaneous and recurrent bleeding. While prophylaxis with clotting factors has improved outcomes, challenges like inhi…
View article: Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)
Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023) Open
INTRODUCTION Multiple Myeloma (MM) is the second most fatal hematological malignancy after Acute Myeloid Leukemia (AML) and incidence rates are increasing in developed countries. Cardiovascular disorders in MM patients can be related to th…
View article: Late-Onset Isolated Drain Site Metastasis in Colorectal Cancer Managed by a Multidisciplinary Approach
Late-Onset Isolated Drain Site Metastasis in Colorectal Cancer Managed by a Multidisciplinary Approach Open
Colorectal cancer (CRC) is one of the most common cancers globally and a leading cause of cancer-related deaths. Over the past decade, our understanding of CRC has significantly evolved, particularly in the areas of genomic prognostication…
View article: Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma
Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma Open
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from adrenal medulla and extra-adrenal paraganglia. Metastatic pheochromocytomas, pose diagnostic and therapeutic challenges due to their atypical presenta…
View article: Impact of Early Testing and Analysis of Germline Genetic Mutation in Patients with Breast Cancer: A Single Institution Experience
Impact of Early Testing and Analysis of Germline Genetic Mutation in Patients with Breast Cancer: A Single Institution Experience Open
Breast cancer is the most common cancer among women worldwide, with germline mutations in high-penetrance genes like BRCA1 and BRCA2, and moderate-penetrance genes such as CHEK2 and ATM contributing majorly to the onset of the same. Univer…
View article: PATH-61. GENOMIC SIGNATURE IN NON-SMALL CELL LUNG CANCER PATIENTS METASTATIC TO BRAIN-A SINGLE INSTITUTION EXPERIENCE
PATH-61. GENOMIC SIGNATURE IN NON-SMALL CELL LUNG CANCER PATIENTS METASTATIC TO BRAIN-A SINGLE INSTITUTION EXPERIENCE Open
BACKGROUND Lung cancer is leading cause of cancer-related death in US, with 10-30 % of NSCLC patients developing brain metastasis, which challenges curative treatment and life expectancy. Somatic mutations in KRAS and EGFR genes have been …
View article: Disseminated Histoplasmosis with Secondary Hemophagocytic Lymphohistiocytosis in a Renal Transplant Recipient on Belatacept-based Immunosuppression
Disseminated Histoplasmosis with Secondary Hemophagocytic Lymphohistiocytosis in a Renal Transplant Recipient on Belatacept-based Immunosuppression Open
Effective post-transplant immunosuppression is essential to induce tolerance to allogeneic tissues and promote long-term graft survival. However, suppression of the immune system significantly increases the risk of opportunistic infections…
View article: Diffuse Subcutaneous Scalp Involvement of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Diffuse Subcutaneous Scalp Involvement of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Open
A 63-year-old man presented to the oncology clinic reporting diffuse scalp swelling for the last 3 months. Magnetic resonance imaging of the head showed diffuse scalp swelling, calvarium destruction, and intracranial extension of the tumor…
View article: Renal Replacement Therapy During Liver Transplant Surgery
Renal Replacement Therapy During Liver Transplant Surgery Open
Liver transplant is the treatment available for eligible patients with end-stage liver cirrhosis. Acute kidney injury and electrolyte abnormalities are associated with liver disease and can be exacerbated by surgery. Intraoperative renal r…
View article: Bispecific Antibodies in Lung Cancer: A State-of-the-Art Review
Bispecific Antibodies in Lung Cancer: A State-of-the-Art Review Open
Bispecific antibodies have emerged as a promising class of therapeutics in the field of oncology, offering an innovative approach to target cancer cells while sparing healthy tissues. These antibodies are designed to bind two different ant…
View article: A case report of abscopal toxicity in a patient with lung adenocarcinoma
A case report of abscopal toxicity in a patient with lung adenocarcinoma Open
The abscopal effect describes tumor responses outside the irradiated field. The literature shows increased overall survival and response rates in patients receiving immunotherapy and radiation, likely from exaggerated abscopal effects. We …
View article: A Case of HER2 Mutated Colorectal Cancer Treated Successfully With Fam-Trastuzumab Deruxtecan
A Case of HER2 Mutated Colorectal Cancer Treated Successfully With Fam-Trastuzumab Deruxtecan Open
Colorectal cancer is a malignant tumor arising from the inner lining of the colon or rectum and is the third most common cancer and the third leading cause of cancer-related deaths in the United States. Human epidermal growth factor recept…
View article: An unusual cause of chronic diarrhea in a <scp>Middle‐Aged</scp> adult: A diagnostic challenge
An unusual cause of chronic diarrhea in a <span>Middle‐Aged</span> adult: A diagnostic challenge Open
Key Clinical Message Diarrhea is a common symptom in medical practice that often gets overlooked. This article is intended to increase the awareness of physicians and other providers on a subtle but important cause of chronic diarrhea.