Ashwin Unnikrishnan
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View article: NPM1 mislocalization mediated by RNA Pol I inhibition alters chromatin landscape
NPM1 mislocalization mediated by RNA Pol I inhibition alters chromatin landscape Open
Summary RNA polymerase I inhibition affects rRNA synthesis from rDNA clusters residing in nucleolar organizer regions (NORs). Here we have demonstrated RNA Pol I inhibition disrupts nucleolar architecture, NPM1 localization, and alters the…
View article: Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs
Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs Open
Hypomethylating agents are frontline therapies for myelodysplastic neoplasms (MDS), yet clinical responses remain unpredictable. We conducted a phase 2 trial comparing injectable and oral azacitidine (AZA) administered over one or three we…
View article: Dysregulated expression of<i>Hoxa1</i>isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes
Dysregulated expression of<i>Hoxa1</i>isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes Open
The homeobox gene, Hoxa1 , has two different isoforms generated by alternative splicing: a full-length homeodomain-containing Hoxa1 ( Hoxa1-FL ), and a truncated Hoxa1 ( Hoxa1-T ), that lacks the homeodomain. Oncoretroviral overexpression …
View article: Data from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth
Data from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth Open
High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and in tissue sections. However, whether constitutive activation and overexpression of CHK1 in GBM pla…
View article: Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth
Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth Open
Figure S1, related to Figure 1: Expression and correlation of CHK1 and CIP2A in multiple glioma cohorts. Figure S2, related to Figure 1: Overall survival and mRNA expression of PP2A subunits in glioma patients. Figure S3, related to Figure…
View article: Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth
Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth Open
Figure S1, related to Figure 1: Expression and correlation of CHK1 and CIP2A in multiple glioma cohorts. Figure S2, related to Figure 1: Overall survival and mRNA expression of PP2A subunits in glioma patients. Figure S3, related to Figure…
View article: Data from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth
Data from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth Open
High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and in tissue sections. However, whether constitutive activation and overexpression of CHK1 in GBM pla…
View article: Supplement Figure 4 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 4 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 4
View article: Supplement Figure 6 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 6 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 6
View article: Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 3, related to main Figure 5.
View article: Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Oncofetal protein SALL4 is critical for cancer cell survival. Targeting SALL4, however, is only applicable in a fraction of cancer patients who are positive for this gene. To overcome this limitation, we propose to induce a cancer vulnerab…
View article: Supplement Figure 2 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 2 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 2
View article: Supplement Figure 6 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 6 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 6
View article: Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Oncofetal protein SALL4 is critical for cancer cell survival. Targeting SALL4, however, is only applicable in a fraction of cancer patients who are positive for this gene. To overcome this limitation, we propose to induce a cancer vulnerab…
View article: Supplement Figure 5 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 5 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 5
View article: Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 3, related to main Figure 5.
View article: Supplement Figure 2 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 2 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 2
View article: Supplementary Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplementary Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplementary tables and figure legends
View article: Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 4, related to main Figure 5. Data pertaining to independent validation in the BEAT-AML cohort.
View article: Supplementary file 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplementary file 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
List of primers used in the paper
View article: Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Purpose:RNA splicing is a fundamental biological process that generates protein diversity from a finite set of genes. Recurrent somatic mutations of splicing factor genes are common in some hematologic cancers but are relatively uncommon i…
View article: Supplementary Figure 1 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 1 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 1, related to main Figure 1
View article: Supplement Figure 3 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 3 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 3
View article: Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 2, related to main Figure 3
View article: Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 2, related to main Figure 3
View article: Supplement Figure 3 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 3 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 3
View article: Supplement Figure 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 1
View article: Supplement Figure 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplement Figure 1 from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplement Figure 1
View article: Supplementary Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Supplementary Data from Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy Open
Supplementary tables and figure legends
View article: Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia Open
Supplementary Figure 4, related to main Figure 5. Data pertaining to independent validation in the BEAT-AML cohort.