Aswin L. Hoffmann
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View article: Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy
Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI‐Guided Proton Therapy Open
Background The integration of MRI‐guidance and proton therapy is a current research topic. Proton therapy with the patient being placed inside an in‐beam MR scanner would require the presence of its static magnetic () field to be taken int…
View article: MR imaging of proton beam‐induced oxygen depletion
MR imaging of proton beam‐induced oxygen depletion Open
Background Previous studies have shown that in‐beam magnetic resonance imaging (MRI) can be used to visualize a proton beam during the irradiation of liquid‐filled phantoms. The beam energy‐ and current‐dependent local image contrast obser…
View article: High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial)
High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial) Open
Introduction The standard treatment for patients with focal drug-resistant epilepsy (DRE) who are not eligible for open brain surgery is the continuation of anti-seizure medication (ASM) and neuromodulation. This treatment does not cure ep…
View article: MRI magnitude signal-based proton beam visualisation in water phantoms reflects composite effects of beam-induced buoyant convection and radiation chemistry
MRI magnitude signal-based proton beam visualisation in water phantoms reflects composite effects of beam-induced buoyant convection and radiation chemistry Open
Objective . Local magnetic resonance (MR) signal loss was previously observed during proton beam irradiation of free-floating water phantoms at ambient temperature using a research prototype in-beam magnetic resonance imaging (MRI) scanner…
View article: Investigation of contrast mechanisms for MRI phase signal‐based proton beam visualization in water phantoms
Investigation of contrast mechanisms for MRI phase signal‐based proton beam visualization in water phantoms Open
Purpose The low sensitivity and limitation to water phantoms of convection‐dependent MRI magnitude signal‐based proton beam visualization hinder its in vivo applicability in MR‐integrated proton beam therapy. The purpose of the present stu…
View article: Direct visualization of proton beam irradiation effects in liquids by MRI
Direct visualization of proton beam irradiation effects in liquids by MRI Open
The main advantage proton beams offer over photon beams in radiation therapy of cancer patients is the dose maximum at their finite range, yielding a reduction in the dose deposited in healthy tissues surrounding the tumor. Since no direct…
View article: Technical note: Experimental dosimetric characterization of proton pencil beam distortion in a perpendicular magnetic field of an in‐beam MR scanner
Technical note: Experimental dosimetric characterization of proton pencil beam distortion in a perpendicular magnetic field of an in‐beam MR scanner Open
Background As it promises more precise and conformal radiation treatments, magnetic resonance imaging‐integrated proton therapy (MRiPT) is seen as a next step in image guidance for proton therapy. The Lorentz force, which affects the cours…
View article: Image Performance Characterization of an <i>In-Beam</i> Low-Field Magnetic Resonance Imaging System During Static Proton Beam Irradiation
Image Performance Characterization of an <i>In-Beam</i> Low-Field Magnetic Resonance Imaging System During Static Proton Beam Irradiation Open
Image guidance using in-beam real-time magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy for moving tumors, by reducing treatment margins, detecting interfractional and intrafractional anatomic…
View article: Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy
Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy Open
Objective To develop an a nthropomorphic, d eformable a nd m ultimodal pelvis phantom with p ositron e mission t omography e xtension for r adiotherapy (ADAM PETer). Methods The design of ADAM PETer was based on our previous pelvis phantom…
View article: Characterization of magnetic interference and image artefacts during simultaneous in-beam MR imaging and proton pencil beam scanning
Characterization of magnetic interference and image artefacts during simultaneous in-beam MR imaging and proton pencil beam scanning Open
For the first time, a low-field open magnetic resonance (MR) scanner was combined with a proton pencil beam scanning (PBS) research beamline. The aim of this study was to characterize the magnetic fringe fields produced by the PBS system a…
View article: Advanced Sandwich Composite Cores for Patient Support in Advanced Clinical Imaging and Oncology Treatment
Advanced Sandwich Composite Cores for Patient Support in Advanced Clinical Imaging and Oncology Treatment Open
Ongoing advances in both imaging and treatment for oncology purposes have seen a significant rise in the use of not only the individual imaging modalities, but also their combination in single systems such as Positron Emission Tomography c…
View article: MRI-Guided-PT: Integrating an MRI in a Proton Therapy System
MRI-Guided-PT: Integrating an MRI in a Proton Therapy System Open
Integration of magnetic resonance imaging (MRI) in proton therapy (PT) has the potential to improve tumor-targeting precision. However, it is technically challenging to integrate an MRI scanner at the beam isocenter of a PT system due to s…
View article: Performing clinical 18F-FDG-PET/MRI of the mediastinum optimising a dedicated, patient-friendly protocol
Performing clinical 18F-FDG-PET/MRI of the mediastinum optimising a dedicated, patient-friendly protocol Open
ECG-triggered T1-VIBE sequences acquired during short, multiple BHs are recommended for mediastinal imaging using F-FDG-PET/MR. With dedicated protocols, F-FDG-PET/MRI will be useful in thoracic oncology and aid in diagnostic evaluation an…
View article: Comparison of pancreatic respiratory motion management with three abdominal corsets for particle radiation therapy: Case study
Comparison of pancreatic respiratory motion management with three abdominal corsets for particle radiation therapy: Case study Open
Background and purpose Abdominal organ motion seriously compromises the targeting accuracy for particle therapy in patients with pancreatic adenocarcinoma. This study compares three different abdominal corsets regarding their ability to re…
View article: Robust Optimization of Dose-Volume Metrics for Prostate HDR-Brachytherapy Incorporating Target and OAR Volume Delineation Uncertainties
Robust Optimization of Dose-Volume Metrics for Prostate HDR-Brachytherapy Incorporating Target and OAR Volume Delineation Uncertainties Open
In radiation therapy planning, uncertainties in the definition of the target volume yield a risk of underdosing the tumor. The traditional corrective action in the context of external beam radiotherapy (EBRT) expands the clinical target vo…
View article: Characterizing geometrical accuracy in clinically optimised 7T and 3T magnetic resonance images for high-precision radiation treatment of brain tumours
Characterizing geometrical accuracy in clinically optimised 7T and 3T magnetic resonance images for high-precision radiation treatment of brain tumours Open
System- and phantom-related GD remained ≤1 mm in central brain regions, suggesting that 7T MR images could be implemented in radiotherapy with clinically acceptable spatial accuracy and equally tolerated GD as in 3T MR/CT-based RTP. For pe…
View article: Technical Note: Experimental verification of magnetic field‐induced beam deflection and Bragg peak displacement for MR‐integrated proton therapy
Technical Note: Experimental verification of magnetic field‐induced beam deflection and Bragg peak displacement for MR‐integrated proton therapy Open
Purpose Given its sensitivity to anatomical variations, proton therapy is expected to benefit greatly from integration with magnetic resonance imaging for online anatomy monitoring during irradiation. Such an integration raises several cha…
View article: Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams
Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams Open
Given the sensitivity of proton therapy to anatomical variations, this cancer treatment modality is expected to benefit greatly from integration with magnetic resonance (MR) imaging. One of the obstacles hindering such an integration are s…