Guresh Kumar
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View article: Comment on “The interplay of hypoxia, inflammation, and microbiota as indicators of malignant transformation in oral potentially malignant disorders”
Comment on “The interplay of hypoxia, inflammation, and microbiota as indicators of malignant transformation in oral potentially malignant disorders” Open
View article: Clinical outcomes with combination of stereotactic body radiation therapy in patients with hepatocellular carcinoma
Clinical outcomes with combination of stereotactic body radiation therapy in patients with hepatocellular carcinoma Open
Purpose: The purpose of the present study was to evaluate outcomes with a combination of stereotactic body radiation therapy (SBRT) for patients with hepatocellular carcinoma (HCC). Materials and Methods: The present retrospective study in…
View article: Low Hepatitis B vaccination coverage in New Delhi, India: urgent call for Universal Adult Hepatitis B vaccination
Low Hepatitis B vaccination coverage in New Delhi, India: urgent call for Universal Adult Hepatitis B vaccination Open
Targeted policies and programs are needed to improve low vaccination rates among older adults in India. The Advisory Committee on Immunization Practices recommends Universal Adult Hepatitis B vaccination, which can eliminate the need for r…
View article: Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease
Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease Open
Using an ethanol-thioacetamide combination in mice results in a faster establishment of AAH with fibrosis than previously known models. Differential protein expression strongly correlates with pathways found altered in human AAH, thus maki…
View article: Impact of educational interventions on hepatitis B and C awareness among school students of Delhi NCR, India
Impact of educational interventions on hepatitis B and C awareness among school students of Delhi NCR, India Open
View article: Treatment Response and Survival with Chemotherapy for Unresectable, Nonmetastatic Cholangiocarcinoma
Treatment Response and Survival with Chemotherapy for Unresectable, Nonmetastatic Cholangiocarcinoma Open
Gupta A, Sahai P, Prasad M, et al. Treatment Response and Survival with Chemotherapy for Unresectable, Nonmetastatic Cholangiocarcinoma. Euroasian J Hepato-Gastroenterol 2024;14(1):5-8.
View article: Impact of coagulopathy assessment with thromboelastography and thromboelastometry on transfusion requirements in critically ill cirrhosis with nonvariceal bleeding: A prospective observational study
Impact of coagulopathy assessment with thromboelastography and thromboelastometry on transfusion requirements in critically ill cirrhosis with nonvariceal bleeding: A prospective observational study Open
Background: Viscoelastic tests are now routinely used for coagulopathy correction in patients with cirrhosis. Thromboelastography (TEG ® ) and rotational thromboelastometry (RoTEM®) are the most widely studied tests in this population. How…
View article: To Evaluate the Efficacy and Safety of Digital Single-Operator Cholangioscopy (DSOC) in Pancreato-Biliary Diseases—One Size Fits All!!!
To Evaluate the Efficacy and Safety of Digital Single-Operator Cholangioscopy (DSOC) in Pancreato-Biliary Diseases—One Size Fits All!!! Open
Background/Aim: Diagnosis and treatment of indeterminate biliary strictures (IS) as well as difficult pancreato-biliary stones is challenging. DSOC offers the advantage of targeted tissue biopsy as well as lithotripsy guided procedures. Ef…
View article: Impact of educational interventions on Hepatitis B and C awareness among school students of Delhi NCR
Impact of educational interventions on Hepatitis B and C awareness among school students of Delhi NCR Open
Background: Viral hepatitis, particularly B and C, is a major cause of liver cirrhosis and cancer, leading to about 1.4 million deaths annually. Alarmingly, less than 20% of those with hepatitis are aware of their status, with only 6.3% re…
View article: e-GLR Score Predicts Early Graft Loss in Adult Live-Donor Liver Transplantation
e-GLR Score Predicts Early Graft Loss in Adult Live-Donor Liver Transplantation Open
Objective: This study aimed to analyze risk factors and develop a predictive model for early allograft loss due to early graft dysfunction (EGD) in adult live-donor liver transplantation (LDLT). Methods: Data of patients who underwent LDLT…
View article: Long Term HBsAg Responses to Peg-Interferon Alpha-2b in HBeAg Negative Chronic Hepatitis B Patients Developing Clinical Relapse after Stopping Long-Term Nucleos(t)ide Analogue Therapy
Long Term HBsAg Responses to Peg-Interferon Alpha-2b in HBeAg Negative Chronic Hepatitis B Patients Developing Clinical Relapse after Stopping Long-Term Nucleos(t)ide Analogue Therapy Open
View article: Real-Time Shear Wave Elastography for Determining the Ideal Site of Liver Biopsy in Diffuse Liver Disease
Real-Time Shear Wave Elastography for Determining the Ideal Site of Liver Biopsy in Diffuse Liver Disease Open
Objectives The objective of the study was to identify accurate site of liver biopsy under ultrasound and elastography guidance and compare the shear wave elastography (SWE) and transient elastography (TE) diagnostic accuracy with histopath…
View article: Non‐resolution of acute kidney injury in the first week portends the development of chronic kidney disease in critically ill patients with cirrhosis
Non‐resolution of acute kidney injury in the first week portends the development of chronic kidney disease in critically ill patients with cirrhosis Open
Summary Background Renal tubular epithelial cells (RTECs) cause maladaptive repair and perpetuate renal fibrosis. Aim To evaluate urinary neutrophil gelatinase‐associated lipocalin (NGAL) and RTEC as risk factors for non‐resolution of acut…
View article: Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis
Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis Open
Dilated and dysfunctional gut lymphatic vessels (LVs) have been reported in experimental cirrhosis. Here, we studied LVs in duodenal (D2)-biopsies of liver cirrhosis patients and investigated the prognostic role of a LV marker, podoplanin …
View article: Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy: Sarcopenia Adds Insult to Injury
Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy: Sarcopenia Adds Insult to Injury Open
Sarcopenia is present in nearly half of the cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt, which increases the risk of a single episode of hepatic encephalopathy by 3-fold and that of multiple episodes of hepa…
View article: Etiologic fractions in patients of Hepatocellular carcinoma in India with and without a background of cirrhosis - a multi-centric study
Etiologic fractions in patients of Hepatocellular carcinoma in India with and without a background of cirrhosis - a multi-centric study Open
Background: Hepatocellular cancer (HCC) typically arises in the background of cirrhosis. Its epidemiology has been changing due to availability of antivirals, changing life-styles and early detection. We undertook a multicentric national s…
View article: Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis
Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis Open
Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is an uncommon form of primary liver carcinoma. It is heterogenous in terms of morphology, immunohistochemistry, radiology, and clinical features; making it a challenging en…
View article: Study of Adherence to Medication in Pediatric Liver Diseases (“SAMPLD” Study) in Indian Children
Study of Adherence to Medication in Pediatric Liver Diseases (“SAMPLD” Study) in Indian Children Open
View article: A comparative histological analysis of early and late graft dysfunction in different time zones following living donor liver transplantation
A comparative histological analysis of early and late graft dysfunction in different time zones following living donor liver transplantation Open
Background: Liver biopsy plays a crucial role in evaluating allograft dysfunction. Comprehensive analysis of the histological spectrum of complications, particularly rejection, in different time zones is lacking. Aim: To evaluate the histo…
View article: Adherence to Immunosuppression in Indian Children after Liver Transplant
Adherence to Immunosuppression in Indian Children after Liver Transplant Open
View article: Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure
Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure Open
Objective The monocyte–macrophage system is central to the host’s innate immune defense and in resolving injury. It is reported to be dysfunctional in acute-on-chronic liver failure (ACLF). The disease-associated alterations in ACLF monocy…
View article: Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis
Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis Open
Background Decompensated cirrhosis patients are more prone to bacterial infections. Myeloid-derived suppressor cells (MDSCs) expand in sepsis patients and disrupt immune cell functions. Granulocyte-macrophage colony-stimulating factor (GM-…
View article: Erectile Dysfunction in Cirrhosis: Its Prevalence and Risk Factors
Erectile Dysfunction in Cirrhosis: Its Prevalence and Risk Factors Open
View article: Soluble factors and suppressive monocytes can predict early development of sepsis in acute‐on‐chronic liver failure
Soluble factors and suppressive monocytes can predict early development of sepsis in acute‐on‐chronic liver failure Open
Patients with acute‐on‐chronic liver failure (ACLF) have a high probability of developing systemic inflammation and sepsis due to immune dysregulation. Fifty‐nine patients with ACLF (12 without and 19 with systemic inflammation, and 28 wit…
View article: Effect of lockdown on children during COVID-19 pandemic–A cross-sectional study
Effect of lockdown on children during COVID-19 pandemic–A cross-sectional study Open
Background and Aim: COVID-19 infection and the pandemic have crippled the global life. Direct effects of infection and its severity among children were yet to define, but its indirect effects and associated consequences were significant bu…
View article: 62nd Annual Conference of the Indian Society of Gastroenterology, February 10th – 13th, 2022, Pune
62nd Annual Conference of the Indian Society of Gastroenterology, February 10th – 13th, 2022, Pune Open
View article: Sarcopenia is the independent predictor of mortality in critically ill patients with cirrhosis
Sarcopenia is the independent predictor of mortality in critically ill patients with cirrhosis Open
Almost 70% of patients with chronic liver disease admitted to the ICU have low muscle mass (sarcopenia). The presence of sarcopenia per se makes them highly prone to infections and increases the chances of death by almost 4-fold; thus, hig…
View article: Identifying critically ill patients with cirrhosis who benefit from nutrition therapy: the mNUTRIC score study
Identifying critically ill patients with cirrhosis who benefit from nutrition therapy: the mNUTRIC score study Open
Critically ill patients with cirrhosis who are at a higher nutritional risk as identified by the mNUTRIC score may have a better survival benefit if higher calorie and protein adequacy are achieved in the ICU.
View article: Cardiac reserve and response to terlipressin in decompensated cirrhosis patients for prediction of development of AKI and mortality: A prospective cohort study
Cardiac reserve and response to terlipressin in decompensated cirrhosis patients for prediction of development of AKI and mortality: A prospective cohort study Open
View article: Maladaptive tubular repair drives non-resolution of acute kidney injury and development of chronic kidney disease in critically ill patients with cirrhosis
Maladaptive tubular repair drives non-resolution of acute kidney injury and development of chronic kidney disease in critically ill patients with cirrhosis Open