Aswin Verhoeven
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View article: Comprehensive lipoprotein and glycoprotein characterization in rheumatoid arthritis plasma and association with clinical markers
Comprehensive lipoprotein and glycoprotein characterization in rheumatoid arthritis plasma and association with clinical markers Open
Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and pain. This study investigates plasma lipoprotein and glycoprotein profiles in RA patients to identify clinically relevant markers for…
View article: Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice Open
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during exercise is a crucial contributor to intestinal epithelial dam…
View article: Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice Open
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during exercise is a crucial contributor to intestinal epithelial dam…
View article: Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice Open
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during exercise is a crucial contributor to intestinal epithelial dam…
View article: The Value of Metabolites and Vitamins for the Assessment of Nutritional Status in Hospitalized Patients
The Value of Metabolites and Vitamins for the Assessment of Nutritional Status in Hospitalized Patients Open
This systematic review aims to summarize the currently available literature regarding the association of plasma metabolites and vitamins with the nutritional status in adult hospitalized patients. A systematic literature search was perform…
View article: Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease
Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease Open
SARS-CoV2 infection results in a range of disease severities, but the underlying differential pathogenesis is still not completely understood. At presentation it remains difficult to estimate and predict severity, in particular, identify i…
View article: Relevance of plasma lipoproteins and small metabolites in assessment of nutritional status among patients with severe injuries
Relevance of plasma lipoproteins and small metabolites in assessment of nutritional status among patients with severe injuries Open
Background: This study aimed to identify plasma lipoproteins and small metabolites associated with high risk of malnutrition during intensive care unit (ICU) stay in patients with severe injuries. Methods: This observational prospective e…
View article: Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus
Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus Open
Type 2 diabetes mellitus (T2DM) poses a higher risk for complications in South Asian individuals compared to other ethnic groups. To shed light on potential mediating factors, we investigated lipidomic changes in plasma of Dutch South Asia…
View article: Distinct Intestinal Microbial Signatures Linked to Accelerated Biological Aging in People with HIV
Distinct Intestinal Microbial Signatures Linked to Accelerated Biological Aging in People with HIV Open
Background People with HIV (PWH), even with controlled viral replication through antiretroviral therapy (ART), experience persistent inflammation. This is partly due to intestinal microbial dysbiosis and translocation. Such ongoing inflamm…
View article: The threat of Peters's Rock Agama (<i>Agama picticauda</i>) to reptile diversity across the Lesser Antilles
The threat of Peters's Rock Agama (<i>Agama picticauda</i>) to reptile diversity across the Lesser Antilles Open
During the ongoing sixth global extinction wave, island ecosystems are among the most impacted due to a high introduction rate of non-native species (Tershy et al., 2015; Bellard, Cassey, & Blackburn, 2016; Fernández-Palacios et al., 2021)…
View article: POS1027 THE LIPOPROTEIN AND LIPID PROFILE CAN PREDICT THE DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
POS1027 THE LIPOPROTEIN AND LIPID PROFILE CAN PREDICT THE DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS Open
Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic and systemic synovial inflammation, cartilage erosion and subsequent joint destruction. Despite the existence of many targeted therapies, RA remains a d…
View article: Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling
Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling Open
Background Composition of high‐density lipoproteins (HDL) is emerging as an important determinant in the development of microvascular complications in type 2 diabetes mellitus (T2DM). Dutch South Asian (DSA) individuals with T2DM display a…
View article: Altered HDL composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: a cross-sectional, case-control study on lipoprotein subclass profiling
Altered HDL composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: a cross-sectional, case-control study on lipoprotein subclass profiling Open
Background: Composition of high-density lipoproteins (HDL) is emerging as an important determinant in the development of microvascular complications in type 2 diabetes mellitus (T2DM). Dutch South Asian (DSA) individuals with T2DM display …
View article: Urinary Metabolic Profiling in Volunteers Undergoing Malaria Challenge in Gabon
Urinary Metabolic Profiling in Volunteers Undergoing Malaria Challenge in Gabon Open
The interaction of malaria parasites with their human host is extensively studied, yet only few studies reported how P. falciparum infection affects urinary metabolite profiles and how this is associated with immunity. We present a longitu…
View article: Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics
Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics Open
The lipid composition of lipoprotein particles is determinative of their respective formation and function. In turn, the combination and correlation of nuclear magnetic resonance (NMR)-based lipoprotein measurements with mass spectrometry …
View article: Comprehensive (apo)lipoprotein profiling in patients with genetic hypertriglyceridemia using LC-MS and NMR spectroscopy
Comprehensive (apo)lipoprotein profiling in patients with genetic hypertriglyceridemia using LC-MS and NMR spectroscopy Open
The lipoprotein profile of patients with genetic HTG is predominated with large lipoproteins (i.e., chylomicrons, VLDL), explaining high levels of apoC-I, apoC-II, apoC-III and apoE, whereas small atherogenic LDL particles are absent. The …
View article: Supplementary Material for: Change in Urinary Myoinositol/Citrate Ratio Associates with Progressive Loss of Renal Function in ADPKD Patients
Supplementary Material for: Change in Urinary Myoinositol/Citrate Ratio Associates with Progressive Loss of Renal Function in ADPKD Patients Open
Introduction: In autosomal dominant polycystic kidney disease (ADPKD) patients, predicting renal disease progression is important to make a prognosis and to support the clinical decision whether to initiate renoprotective therapy. Conventi…
View article: Change in Urinary Myoinositol/Citrate Ratio Associates with Progressive Loss of Renal Function in ADPKD Patients
Change in Urinary Myoinositol/Citrate Ratio Associates with Progressive Loss of Renal Function in ADPKD Patients Open
Introduction: In autosomal dominant polycystic kidney disease (ADPKD) patients, predicting renal disease progression is important to make a prognosis and to support the clinical decision whether to initiate renoprotective therapy. Conventi…
View article: Perspectives on automated composition of workflows in the life sciences
Perspectives on automated composition of workflows in the life sciences Open
Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due…
View article: Asymptomatic gut colonization by extended-spectrum beta-lactamase-producing <i>Escherichia coli</i> is not associated with an altered gut microbiome or metabolome in Dutch adults
Asymptomatic gut colonization by extended-spectrum beta-lactamase-producing <i>Escherichia coli</i> is not associated with an altered gut microbiome or metabolome in Dutch adults Open
Background Gut colonization by antibiotic resistant E. coli strains, including extended-spectrum beta-lactamase (ESBL)-producing E. coli is a risk factor for developing overt infection. The gut microbiome can provide colonization resistanc…
View article: Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition Open
Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown. Here, we identify microbiota-derive…
View article: Metabolic Homeostasis in Chronic Helminth Infection Is Sustained by Organ-Specific Metabolic Rewiring
Metabolic Homeostasis in Chronic Helminth Infection Is Sustained by Organ-Specific Metabolic Rewiring Open
Opisthorchiasis, is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae. A chronic form of the disease implies a prolonged coexistence of a host and the parasite. The pathological changes inflicted by the worm …
View article: Author response: Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Author response: Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Previous studies have identified a crucial…