Asya Makhro
YOU?
Author Swipe
View article: A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture
A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture Open
When Neanderthals and anatomically modern humans interbred, they may have faced conditional reproductive barriers. We identify a likely maternal-fetal incompatibility involving a Neanderthal PIEZO1 gene variant predicted to increase red bl…
View article: Topologically Regularized Multiple Instance Learning to Harness Data Scarcity
Topologically Regularized Multiple Instance Learning to Harness Data Scarcity Open
In biomedical data analysis, Multiple Instance Learning (MIL) models have emerged as a powerful tool to classify patients' microscopy samples. However, the data-intensive requirement of these models poses a significant challenge in scenari…
View article: RedTell: an AI tool for interpretable analysis of red blood cell morphology
RedTell: an AI tool for interpretable analysis of red blood cell morphology Open
Introduction: Hematologists analyze microscopic images of red blood cells to study their morphology and functionality, detect disorders and search for drugs. However, accurate analysis of a large number of red blood cells needs automated c…
View article: Red Blood Cell RedTell Dataset
Red Blood Cell RedTell Dataset Open
The dataset contains microscopic images of red blood cells (RBCs) and consists of two parts: 1. dse_data.zip This dataset includes brightfield images of healthy control individuals obtained in the scope of the CoMMiTMenT study. The images …
View article: Red Blood Cell RedTell Dataset
Red Blood Cell RedTell Dataset Open
The dataset contains microscopic images of red blood cells (RBCs) and consists of two parts: 1. dse_data.zip This dataset includes brightfield images of healthy control individuals obtained in the scope of the CoMMiTMenT study. The images …
View article: Red Blood Cell RedTell Dataset
Red Blood Cell RedTell Dataset Open
The dataset contains microscopic images of red blood cells (RBCs) and consists of two parts: 1. dse_data.zip This dataset includes brightfield images of healthy control individuals obtained in the scope of the CoMMiTMenT study. The images …
View article: Red Blood Cell RedTell Dataset
Red Blood Cell RedTell Dataset Open
The dataset contains microscopic images of red blood cells (RBCs) and consists of two parts: 1. dse_data.zip This dataset includes brightfield images of healthy control individuals obtained in the scope of the CoMMiTMenT study. The images …
View article: Simple Assessment of Red Blood Cell Deformability Using Blood Pressure in Capillary Channels for Effective Detection of Subpopulations in Red Blood Cells
Simple Assessment of Red Blood Cell Deformability Using Blood Pressure in Capillary Channels for Effective Detection of Subpopulations in Red Blood Cells Open
Assessment of red blood cell (RBC) deformability as a biomarker requires expensive equipment to induce and monitor deformation. In this study, we present a simple method for quantifying RBC deformability. We designed a microfluidic channel…
View article: The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism
The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism Open
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure. Chronic inflammatory state …
View article: Anomaly-aware multiple instance learning for rare anemia disorder classification
Anomaly-aware multiple instance learning for rare anemia disorder classification Open
Deep learning-based classification of rare anemia disorders is challenged by the lack of training data and instance-level annotations. Multiple Instance Learning (MIL) has shown to be an effective solution, yet it suffers from low accuracy…
View article: PB2222: THE PROTECTIVE EFFECT OF THE SPLEEN IN SICKLE CELL PATIENTS. A COMPARATIVE STUDY BETWEEN PATIENTS WITH ASPLENIA AND HYPERSPLENISM.
PB2222: THE PROTECTIVE EFFECT OF THE SPLEEN IN SICKLE CELL PATIENTS. A COMPARATIVE STUDY BETWEEN PATIENTS WITH ASPLENIA AND HYPERSPLENISM. Open
Background: Sickle cell disease (SCD) is caused by a point mutation in the beta globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia and progressive organ failure. A chronic inflam…
View article: Continuous Percoll Gradient Centrifugation of Erythrocytes—Explanation of Cellular Bands and Compromised Age Separation
Continuous Percoll Gradient Centrifugation of Erythrocytes—Explanation of Cellular Bands and Compromised Age Separation Open
(1) Background: When red blood cells are centrifuged in a continuous Percoll-based density gradient, they form discrete bands. While this is a popular approach for red blood cell age separation, the mechanisms involved in banding were unkn…
View article: Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn
Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn Open
This dataset refers to the article "Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn" Acta Physiologica. 2021;232:e13647 https://doi.org/10.1111/apha.13647
View article: Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn
Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn Open
This dataset refers to the article "Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn" Acta Physiologica. 2021;232:e13647 https://doi.org/10.1111/apha.13647
View article: Sickle Cell Disease Severity Prediction from Percoll Gradient Images\n using Graph Convolutional Networks
Sickle Cell Disease Severity Prediction from Percoll Gradient Images\n using Graph Convolutional Networks Open
Sickle cell disease (SCD) is a severe genetic hemoglobin disorder that\nresults in premature destruction of red blood cells. Assessment of the severity\nof the disease is a challenging task in clinical routine since the causes of\nbroad va…
View article: Fourier Transform of Percoll Gradients Boosts CNN Classification of Hereditary Hemolytic Anemias
Fourier Transform of Percoll Gradients Boosts CNN Classification of Hereditary Hemolytic Anemias Open
Hereditary hemolytic anemias are genetic disorders that affect the shape and density of red blood cells. Genetic tests currently used to diagnose such anemias are expensive and unavailable in the majority of clinical labs. Here, we propose…
View article: Absence of neocytolysis in humans returning from a 3‐week high‐altitude sojourn
Absence of neocytolysis in humans returning from a 3‐week high‐altitude sojourn Open
Aims Total haemoglobin mass (tot‐Hb) increases during high‐altitude acclimatization. Normalization of tot‐Hb upon descent is thought to occur via neocytolysis, the selective destruction of newly formed erythrocytes. Because convincing expe…
View article: Fourier Transform of Percoll Gradients Boosts CNN Classification of\n Hereditary Hemolytic Anemias
Fourier Transform of Percoll Gradients Boosts CNN Classification of\n Hereditary Hemolytic Anemias Open
Hereditary hemolytic anemias are genetic disorders that affect the shape and\ndensity of red blood cells. Genetic tests currently used to diagnose such\nanemias are expensive and unavailable in the majority of clinical labs. Here,\nwe prop…
View article: Sickle Cell Disease Severity Prediction from Percoll Gradient Images Using Graph Convolutional Networks
Sickle Cell Disease Severity Prediction from Percoll Gradient Images Using Graph Convolutional Networks Open
View article: Gardos channelopathy: functional analysis of a novel <i>KCNN4</i> variant
Gardos channelopathy: functional analysis of a novel <i>KCNN4</i> variant Open
Key Points We show that the novel KCNN4 variant p.S314P is a gain-of-function mutation but is less severe than the previously reported p.R352H variant. The clinical heterogeneity, blurred symptoms, and absence of specific diagnostic marker…
View article: MEMSID: Results From a Phase 2 Pilot Study on Memantine Treatment for Sickle Cell Disease
MEMSID: Results From a Phase 2 Pilot Study on Memantine Treatment for Sickle Cell Disease Open
Supplemental Digital Content is available in the text
View article: N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?
N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned? Open
The N-methyl-D-aspartate receptor (NMDAR) provides a pathway for glutamate-mediated inter-cellular communication, best known for its role in the brain but with multiple examples of functionality in non-neuronal cells. Data previousl…
View article: Heterogeneity of Red Blood Cells: Causes and Consequences
Heterogeneity of Red Blood Cells: Causes and Consequences Open
Mean values of hematological parameters are currently used in the clinical laboratory settings to characterize red blood cell properties. Those include red blood cell indices, osmotic fragility test, eosin 5-maleimide (EMA) test, and defor…
View article: Attention Based Multiple Instance Learning for Classification of Blood Cell Disorders
Attention Based Multiple Instance Learning for Classification of Blood Cell Disorders Open
View article: Aging Markers in Equine Red Blood Cells
Aging Markers in Equine Red Blood Cells Open
Detection of hematopoietic activity in horses is a challenge due to the lack of cells carrying reticulocyte markers such as RNA remnants or CD71 in the circulation. In this study, we fractionated equine red cells according to their density…
View article: Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis
Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis Open
Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deforma…
View article: Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias Open
Congenital haemolytic anaemias are inherited disorders caused by red blood cell membrane and cytoskeletal protein defects, deviant hemoglobin synthesis and metabolic enzyme deficiencies. In many cases, although the causing mutation might b…
View article: Multiclass Deep Active Learning for Detecting Red Blood Cell Subtypes in Brightfield Microscopy
Multiclass Deep Active Learning for Detecting Red Blood Cell Subtypes in Brightfield Microscopy Open
View article: A Previously Unrecognized Ca<sup>2+</sup>‐inhibited Nonselective Cation Channel in Red Blood Cells
A Previously Unrecognized Ca<sup>2+</sup>‐inhibited Nonselective Cation Channel in Red Blood Cells Open
Supplemental Digital Content is available in the text
View article: Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?
Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia? Open
For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellula…