Atchariya Chanpong
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View article: Early-Life Events and the Prevalence of Gut–Brain Interaction Disorders in Children
Early-Life Events and the Prevalence of Gut–Brain Interaction Disorders in Children Open
Background/Objectives: Disorders of gut–brain interaction (DGBI) include a spectrum of disorders with chronic/recurrent gastrointestinal symptoms, caused by dysregulation of microbiota–gut–brain interaction. Early-life events have been sug…
View article: Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development
Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development Open
Background and aims Intestinal motility relies on inputs from multiple cells within a complex neuromuscular syncytium located in the gut wall. While it is known that motility is dependent on the development of motor patterns which govern c…
View article: Colonic transit studies and colonic manometry in pediatric constipation
Colonic transit studies and colonic manometry in pediatric constipation Open
Objectives In a subgroup of children with refractory constipation, colonic function investigations, such as colonic transit scintigraphy (CS) and colonic manometry (CM), are used to define the underlying pathophysiologic mechanisms. There …
View article: The Potential Role of Microorganisms on Enteric Nervous System Development and Disease
The Potential Role of Microorganisms on Enteric Nervous System Development and Disease Open
The enteric nervous system (ENS), the inherent nervous system of the gastrointestinal (GI) tract is a vast nervous system that controls key GI functions, including motility. It functions at a critical interface between the gut luminal cont…
View article: Recent advances in understanding the roles of the enteric nervous system
Recent advances in understanding the roles of the enteric nervous system Open
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its complex circuitry and neuronal diversity, the ENS …
View article: Wilson disease in children and young adults - State of the art
Wilson disease in children and young adults - State of the art Open
Wilson disease (WD) is an autosomal recessive disorder caused by mutations of the ATP7B gene, with a reported prevalence of 1:30,000–50,000. ATP7B encodes an enzyme called transmembrane copper-transporting ATPase, which is essential for co…
View article: Mental Health, Cognitive, and Neuropsychiatric Needs in Children and Young People With Wilson Disease
Mental Health, Cognitive, and Neuropsychiatric Needs in Children and Young People With Wilson Disease Open
Objective: Wilson disease (WD) is associated with neurological, psychiatric, cognitive, and psychosocial difficulties, but there is little data regarding the nature and prevalence of these problems in children and young people (CYP). Metho…
View article: Congenital Cytomegalovirus Infection Presenting with Isolated Secretory Diarrhoea Mimicking a Congenital Diarrhoeal Disorder
Congenital Cytomegalovirus Infection Presenting with Isolated Secretory Diarrhoea Mimicking a Congenital Diarrhoeal Disorder Open
To the best of our knowledge, a congenital cytomegalovirus (CMV) infection presenting with only secretory diarrhoeal symptoms without other apparent clinical features of CMV infection has never been reported. We describe an infant with con…
View article: Laxative Choice and Treatment Outcomes in Childhood Constipation: Clinical Data in a Longitudinal Retrospective Study
Laxative Choice and Treatment Outcomes in Childhood Constipation: Clinical Data in a Longitudinal Retrospective Study Open
Treatment outcomes between patients who had and never had PEG demonstrated no significant difference in our study. Hence, current practices in laxative prescriptive patterns may be effective.