Athanasios Alegakis
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View article: Insights into the Prognostic Value of Telomere Length in Childhood Acute Lymphoblastic Leukemia
Insights into the Prognostic Value of Telomere Length in Childhood Acute Lymphoblastic Leukemia Open
Background: Although telomere length maintenance is a common characteristic of hematological malignancies, the role of telomere length as a prognostic factor to stratify acute lymphoblastic leukemia (ALL) patients depending on their risk o…
View article: Job Satisfaction Among Healthcare Professionals in Community-Based Care for Older People: Evidence from Greece
Job Satisfaction Among Healthcare Professionals in Community-Based Care for Older People: Evidence from Greece Open
Objectives: This study aimed to investigate the level of job satisfaction and the associated factors among health and social care employees of the public sector providing services in open care community settings and home-based care for the…
View article: Correlation of telomere length between full and preterm neonates and their mothers
Correlation of telomere length between full and preterm neonates and their mothers Open
Telomeres are nucleoprotein complexes that serve as protective caps from the DNA damage response at the ends of chromosomes. During aging, telomeres gradually shorten, and genomic instability arises through the induction of senescence. The…
View article: Health Professionals’ Views on Euthanasia: Impact of Traits, Religiosity, Death Perceptions, and Empathy
Health Professionals’ Views on Euthanasia: Impact of Traits, Religiosity, Death Perceptions, and Empathy Open
Context: A plethora of actors like individual and professional characteristics, religiosity, personality-related factors, personal experience of death, and empathy form the attitude of health professionals in patient care in clinical setti…
View article: Evaluation of the Diagnostic and Predictive Significance of Postoperative C-Reactive Protein to Transferrin or Albumin Ratio in Identifying Septic Events Following Major Abdominal Surgery
Evaluation of the Diagnostic and Predictive Significance of Postoperative C-Reactive Protein to Transferrin or Albumin Ratio in Identifying Septic Events Following Major Abdominal Surgery Open
Background/Objectives: Postoperative septic events represent a major paramevter of morbidity and mortality following major abdominal surgery. Early identification and prediction can have a major impact on clinical management, reduction of …
View article: Evaluation of the Diagnostic and Predictive Significance of Postoperative C-Reactive Protein to Transferrin or Albumin Ratio in Identifying Septic Events Following Major Abdominal Surgery
Evaluation of the Diagnostic and Predictive Significance of Postoperative C-Reactive Protein to Transferrin or Albumin Ratio in Identifying Septic Events Following Major Abdominal Surgery Open
Background/Objectives: Postoperative septic events represent a major parameter of morbidity and mortality following major abdominal surgery. Early identification and prediction can have a major impact in clinical management, reduction of h…
View article: Cyclin E Expression and p16 Loss Are Strong Prognostic Biomarkers in Primary Invasive Cutaneous Melanoma
Cyclin E Expression and p16 Loss Are Strong Prognostic Biomarkers in Primary Invasive Cutaneous Melanoma Open
Expression of Cyclin E and loss of p16 appeared to be significant prognostic biomarkers, with Cyclin E being prognostically at least as strong as Breslow thickness regarding RFS and OS. Both biomarkers may potentially be used to improve st…
View article: Evaluating the effect of individual characteristics and COVID‐19 pandemic on people living under extreme poverty conditions in Greece
Evaluating the effect of individual characteristics and COVID‐19 pandemic on people living under extreme poverty conditions in Greece Open
Poverty dimensions and COVID‐19 are risk factors for a low quality of life and anxiety. The aims of this study are to: (a) examine the quality of life and anxiety levels of citizens living under poverty and (b) explore whether this populat…
View article: Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights
Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights Open
In modern athlete assessment, the integration of conventional biochemical and ergophysiologic monitoring with innovative methods like telomere analysis, genotyping/phenotypic profiling, and metabolomics has the potential to offer a compreh…
View article: Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units
Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) represented a global public health crisis and the most significant pandemic in modern times. Transmission characte…
View article: A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats
A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats Open
Telomeres are major contributors to cell fate and aging through their involvement in cell cycle arrest and senescence. The accelerated attrition of telomeres is associated with aging‑related diseases, and agents able to maintain telomere l…
View article: DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach
DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach Open
Exposure to chemical substances has always been a matter of concern for the scientific community. During the last few years, researchers have been focusing on studying the effects resulting from combined exposure to different substances. I…
View article: Stress and Prevalence of Musculoskeletal Disorders Among the Nursing Personnel of a Tertiary Hospital Unit in Greece: A Cross-Sectional Study.
Stress and Prevalence of Musculoskeletal Disorders Among the Nursing Personnel of a Tertiary Hospital Unit in Greece: A Cross-Sectional Study. Open
Musculoskeletal disorders were common among the nursing personnel. Higher levels of stress were related with a higher prevalence of musculoskeletal symptoms.
View article: Antibiotics in Raw Meat Samples: Estimation of Dietary Exposure and Risk Assessment
Antibiotics in Raw Meat Samples: Estimation of Dietary Exposure and Risk Assessment Open
The extensive use of antibiotics in livestock farming poses increased concerns for human health as residues of these substances are present in edible tissues. The aim of this study was the determination of the levels of four groups of anti…
View article: In Vivo Estimation of the Biological Effects of Endocrine Disruptors in Rabbits after Combined and Long-Term Exposure: Study Protocol
In Vivo Estimation of the Biological Effects of Endocrine Disruptors in Rabbits after Combined and Long-Term Exposure: Study Protocol Open
Recently, an increasing number of chemical compounds are being characterized as endocrine disruptors since they have been proven to interact with the endocrine system, which plays a crucial role in the maintenance of homeostasis. Glyphosat…
View article: The effect of tranexamic acid on blood loss in non-urgent trauma patients undergoing major orthopaedic surgery: A retrospective cohort study
The effect of tranexamic acid on blood loss in non-urgent trauma patients undergoing major orthopaedic surgery: A retrospective cohort study Open
Objectives: This study aims to clarify the role of prophylactic TXA on blood loss and transfusion requirements in a subgroup of trauma patients undergoing major orthopaedic surgery on a non-urgent basis. Study design: This is a retrospecti…
View article: Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes
Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes Open
Purpose Due to the current practice on colorectal cancer (CRC) management, chemoresistance is most often recognized at the end of the treatment. Therefore, effective and easy-to-use prognostic biomarkers are needed. Experimental Design We …
View article: Self-Reported Assessment of Empathy and Its Variations in a Sample of Greek Social Workers
Self-Reported Assessment of Empathy and Its Variations in a Sample of Greek Social Workers Open
The aim of the study was twofold: (a) to examine the way in which professional social workers perceive and apply in their practice the concept of empathy; (b) to explore sociodemographic factors, education/special training and work charact…
View article: Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives Open
Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging‑related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be revers…
View article: Comparison of self-reported adherence to cervical and breast cancer screening guidelines in relation to the researcher’s profession.
Comparison of self-reported adherence to cervical and breast cancer screening guidelines in relation to the researcher’s profession. Open
Introduction: Self-reporting is a major and, in many cases, the only feasible method to use in cancer screening research. However, its validity has been questioned and numerous studies indicate that women over-report their participation in…
View article: Association of nutraceutical supplements with longer telomere length
Association of nutraceutical supplements with longer telomere length Open
Telomeres are nucleotide tandem repeats located at the tip of eukaryotic chromosomes that maintain genomic integrity. The gradual shortening of telomeres leads to cellular senescence and apoptosis, a key mechanism of aging and age‑related …
View article: Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age
Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age Open
Introduction: Telomere length (TL) is causally related to aging and several age-related diseases. Specifically, the abundance of short telomeres and the rate of telomere shortening are strong determinants of cell homeostasis. Thus, tools f…
View article: Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults
Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults Open
Fatty acids (FAs) play critical roles in health and disease. The detection of FA imbalances through metabolomics can provide an overview of an individual's health status, particularly as regards chronic inflammatory disorders. In this stud…
View article: Application of metabolomics: Focus on the quantification of organic acids in healthy adults
Application of metabolomics: Focus on the quantification of organic acids in healthy adults Open
Metabolomics, a 'budding' discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effec…