Athanasios Chalkias
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View article: Heart–Lung Interactions in Combined Distributive Shock and ARDS: Applied Cardiopulmonary Physiology at the Bedside
Heart–Lung Interactions in Combined Distributive Shock and ARDS: Applied Cardiopulmonary Physiology at the Bedside Open
Distributive shock and acute respiratory distress syndrome (ARDS) are syndromes of profound pathophysiological complexity, each independently associated with high morbidity and mortality. When coexistent, they create a state of synergistic…
View article: Vasopressor Modulation of Cerebral Autoregulation and Systemic Hemodynamics in Severe Traumatic Brain Injury: The REGULATE randomized controlled trial
Vasopressor Modulation of Cerebral Autoregulation and Systemic Hemodynamics in Severe Traumatic Brain Injury: The REGULATE randomized controlled trial Open
Background Severe traumatic brain injury (TBI) frequently disrupts cerebral autoregulation, rendering cerebral perfusion pressure highly dependent on systemic hemodynamics. Vasopressors are a cornerstone of TBI management, yet norepineph-r…
View article: Multimodal Assessment of Peripheral Perfusion for the Early Diagnosis of Sepsis in Critically Ill Patients (MAP-SEPS): A Protocol for an Observational Study
Multimodal Assessment of Peripheral Perfusion for the Early Diagnosis of Sepsis in Critically Ill Patients (MAP-SEPS): A Protocol for an Observational Study Open
Introduction: Sepsis-induced organ failure is caused by a dysregulated host response characterized by mitochondrial and microcirculatory abnormalities. Early detection of perfusion deficits is critical to preventing progression to shock an…
View article: Oxygen-Mediated Molecular Mechanisms Involved in Intestinal Ischemia and Reperfusion Injury
Oxygen-Mediated Molecular Mechanisms Involved in Intestinal Ischemia and Reperfusion Injury Open
The gastrointestinal tract is affected by multiple ailments that manifest with similar chemical, subcellular, and cellular changes, such as those in intestinal ischemia–reperfusion injury (IRI). The main chemical changes that are described…
View article: Regional sepsis care in Catalonia: comparative insights from a secondary analysis of the European Sepsis Care Survey
Regional sepsis care in Catalonia: comparative insights from a secondary analysis of the European Sepsis Care Survey Open
No abstract available
View article: On the Intensity of the Microvascular Magnetic Field in Normal State and Septic Shock
On the Intensity of the Microvascular Magnetic Field in Normal State and Septic Shock Open
Background: Capillary tortuosity is a morphological variant of microcirculation. However, the mechanisms by which tortuous vessels meet metabolic requirements in health and disease remain unknown. We recently reported that capillary tortuo…
View article: Characterization of Sublingual Microvascular Tortuosity in Steady-State Physiology and Septic Shock
Characterization of Sublingual Microvascular Tortuosity in Steady-State Physiology and Septic Shock Open
Background: The characteristics of hemodynamic coherence in healthy states and disease remain unknown. Capillary tortuosity is a morphologic variant of microcirculatory vessels, but its effects have generally not been considered in the ass…
View article: Critical Illness Polyneuropathy: a multicenter study on functional outcome
Critical Illness Polyneuropathy: a multicenter study on functional outcome Open
Objective. To describe the functional recovery of consecutive inpatients with Critical Illness Polyneuropathy (CIP) at the time-point of the discharge from rehabilitation units according to Barthel Index scores. To examine whether age, gen…
View article: Characterization of Sublingual Microvascular Tortuosity in Steady-State Physiology and Septic Shock
Characterization of Sublingual Microvascular Tortuosity in Steady-State Physiology and Septic Shock Open
Background: The characteristics of hemodynamic coherence in healthy states and disease remain unknown. Capillary tortuosity is a morphologic variant of microcirculatory vessels but its effects have generally not been considered in the asse…
View article: Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury
Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury Open
The gastrointestinal tract can be deranged by ailments including sepsis, trauma and haemorrhage. Ischaemic injury provokes a common constellation of microscopic and macroscopic changes that, together with the paradoxical exacerbation of ce…
View article: Transitions from Aerobic to Anaerobic Metabolism and Oxygen Debt during Elective Major and Emergency Non-Cardiac Surgery
Transitions from Aerobic to Anaerobic Metabolism and Oxygen Debt during Elective Major and Emergency Non-Cardiac Surgery Open
Introduction: Intraoperative hemodynamic and metabolic optimization of both the high-risk surgical patients and critically ill patients remains challenging. Reductions in oxygen delivery or increases in oxygen consumption can initiate comp…
View article: Cancer-Induced Resting Sinus Tachycardia: An Overlooked Clinical Diagnosis
Cancer-Induced Resting Sinus Tachycardia: An Overlooked Clinical Diagnosis Open
Elevated resting heart rate is frequently observed in cancer patients, and is associated with increased mortality. Although specific chemotherapeutic agents can induce cardiotoxicity, the presence of sinus tachycardia in chemotherapy-naive…
View article: ANGIOTENSIN II IN THE TREATMENT OF DISTRIBUTIVE SHOCK: A SYSTEMATIC-REVIEW AND META-ANALYSIS
ANGIOTENSIN II IN THE TREATMENT OF DISTRIBUTIVE SHOCK: A SYSTEMATIC-REVIEW AND META-ANALYSIS Open
Objective: While nonnorepinephrine vasopressors are increasingly used as a rescue therapy in cases of norepinephrine-refractory shock, data on their efficacy are limited. This systematic review and meta-analysis aims to synthesize existing…
View article: A critical reappraisal of vasopressin and steroids in in-hospital cardiac arrest
A critical reappraisal of vasopressin and steroids in in-hospital cardiac arrest Open
Epinephrine during resuscitationAdvanced life support (ALS) objectives include maximization of coronary perfusion pressure (CPP) for prompt return of spontaneous circulation (ROSC) and minimization of cardiac arrest-associated ischemia-rep…
View article: Cancer-Induced Resting Sinus Tachycardia: An Overlooked Clinical Diagnosis
Cancer-Induced Resting Sinus Tachycardia: An Overlooked Clinical Diagnosis Open
Elevated resting heart rate is frequently observed in cancer patients, and is associated with increased mortality. Although specific chemotherapeutic agents can induce cardiotoxicity, the presence of sinus tachycardia in chemotherapy-naive…
View article: Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study
Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study Open
Context Obesity is a risk factor for coronavirus disease 2019 (COVID-19)-related outcomes; however, the mechanism remains unclear. Objective The objective of this analysis was to determine whether inflammation mediates the association betw…
View article: Effect of Centhaquine on the Coagulation Cascade in Normal State and Uncontrolled Hemorrhage: A Multiphase Study Combining Ex Vivo and In Vivo Experiments in Different Species
Effect of Centhaquine on the Coagulation Cascade in Normal State and Uncontrolled Hemorrhage: A Multiphase Study Combining Ex Vivo and In Vivo Experiments in Different Species Open
Centhaquine is a novel vasopressor acting on α2A- and α2B-adrenoreceptors, increasing venous return and improving tissue perfusion. We investigated the effects of centhaquine on blood coagulation in normal state and uncontrolled hemorrhage…
View article: Protease-Activated Receptors (PARs): Biology and Therapeutic Potential in Perioperative Stroke
Protease-Activated Receptors (PARs): Biology and Therapeutic Potential in Perioperative Stroke Open
Perioperative stroke is a devastating complication that occurs during surgery or within 30 days following the surgical procedure. Its prevalence ranges from 0.08 to 10% although it is most likely an underestimation, as sedatives and narcot…
View article: SuPAR, biomarkers of inflammation, and severe outcomes in patients hospitalized for COVID‐19: The International Study of Inflammation in COVID‐19
SuPAR, biomarkers of inflammation, and severe outcomes in patients hospitalized for COVID‐19: The International Study of Inflammation in COVID‐19 Open
Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted a prospective multicenter observational study of adult patien…
View article: Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology
Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology Open
Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimul…
View article: Temperature control after successful resuscitation from cardiac arrest in adults: a joint statement from the European Society for Emergency Medicine (EUSEM) and the European Society of Anaesthesiology and Intensive Care (ESAIC)
Temperature control after successful resuscitation from cardiac arrest in adults: a joint statement from the European Society for Emergency Medicine (EUSEM) and the European Society of Anaesthesiology and Intensive Care (ESAIC) Open
Background Out-of-hospital cardiac arrest (OHCA) is the third leading cause of death in Europe, with a high burden of disability for patients and their families [1]. When the heart stops, the body and brain cells quickly deplete of oxygen.…
View article: Temperature control after successful resuscitation from cardiac arrest in adults
Temperature control after successful resuscitation from cardiac arrest in adults Open
Background Out-of-hospital cardiac arrest (OHCA) is the third leading cause of death in Europe, and results in a high burden of disability for patients and their families.1 When the heart stops, the body and brain cells quickly deplete of …
View article: Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies
Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies Open
Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been prop…
View article: Peri-operative night-time work of anaesthesiologists
Peri-operative night-time work of anaesthesiologists Open
BACKGROUND Qualitative data on the opinions of anaesthesiologists regarding the impact of peri-operative night-time working conditions on patient safety are lacking. OBJECTIVE(S) This study aimed to achieve in-depth understanding of anaest…