Athanasios Simoulis
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View article: Longitudinal outcome prediction of prostate cancer patients on active surveillance using multiple instance learning
Longitudinal outcome prediction of prostate cancer patients on active surveillance using multiple instance learning Open
We show that avoiding Gleason grades is beneficial for longitudinal outcome prediction of prostate cancer. Our results suggest that benign prostate tissue contains prognostic information. However, before our models could be used clinically…
View article: Artificial intelligence for detection of prostate cancer in biopsies during active surveillance
Artificial intelligence for detection of prostate cancer in biopsies during active surveillance Open
Objectives To evaluate a cancer detecting artificial intelligence (AI) algorithm on serial biopsies in patients with prostate cancer on active surveillance (AS). Patients and methods A total of 180 patients in the Prostate Cancer Research …
View article: An 18-Gene Algorithm urine test for predicting prostate cancer metastasis and castration- resistance
An 18-Gene Algorithm urine test for predicting prostate cancer metastasis and castration- resistance Open
Background There is an urgent need to accurately predict the risk of distant metastasis and metastatic castration-resistant prostate cancer (mCRPC) for treatment decision-making and reducing mortality. An artificial intelliegnce machine le…
View article: Supplemental Figure 2 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 2 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Evaluate bone marrow metastasis initiated by PC3M cells via intracardiac injection of tumor cells into mice.
View article: Supplemental Informaiton from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Informaiton from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Supplemental Materials and Methods and figure text for supplemental figures
View article: Supplemental Figure 2 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 2 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Evaluate bone marrow metastasis initiated by PC3M cells via intracardiac injection of tumor cells into mice.
View article: Supplemental Figure 1 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 1 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
PC3M cells overexpressing cyclin A1 initiated macro-metastases in distant organs in xenograft mice.
View article: Supplemental Figure 3 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 3 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Evaluate bone marrow metastasis initiated by PC3M cells via intracardiac injection of tumor cells into mice.
View article: Supplemental Figure 1 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 1 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
PC3M cells overexpressing cyclin A1 initiated macro-metastases in distant organs in xenograft mice.
View article: Data from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Data from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as a cell of origin for prostate cancer metastasis, the pathways that enable metastatic development at dist…
View article: Data from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Data from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as a cell of origin for prostate cancer metastasis, the pathways that enable metastatic development at dist…
View article: Supplemental Informaiton from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Informaiton from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Supplemental Materials and Methods and figure text for supplemental figures
View article: Supplemental Figure 3 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Supplemental Figure 3 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Evaluate bone marrow metastasis initiated by PC3M cells via intracardiac injection of tumor cells into mice.
View article: FDG-PET/CT for lymph node staging in bladder cancer treated with radical cystectomy
FDG-PET/CT for lymph node staging in bladder cancer treated with radical cystectomy Open
Background 18 F-Flourodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC). Objective Our aim w…
View article: K-RAS Associated Gene-Mutation-Based Algorithm for Prediction of Treatment Response of Patients with Subtypes of Breast Cancer and Especially Triple-Negative Cancer
K-RAS Associated Gene-Mutation-Based Algorithm for Prediction of Treatment Response of Patients with Subtypes of Breast Cancer and Especially Triple-Negative Cancer Open
Purpose: There is an urgent need for developing new biomarker tools to accurately predict treatment response of breast cancer, especially the deadly triple-negative breast cancer. We aimed to develop gene-mutation-based machine learning (M…
View article: Gene-Mutation-Based Algorithm for Prediction of Treatment Response in Colorectal Cancer Patients
Gene-Mutation-Based Algorithm for Prediction of Treatment Response in Colorectal Cancer Patients Open
Purpose: Despite the high mortality of metastatic colorectal cancer (mCRC), no new biomarker tools are available for predicting treatment response. We developed gene-mutation-based algorithms as a biomarker classifier to predict treatment …
View article: FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer Open
Low‐affinity immunoglobulin gamma Fc region receptor III‐A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of F…
View article: Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients
Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients Open
Objective: To avoid over-treatment of low-risk prostate cancer patients, it is important to identify clinically significant and insignificant cancer for treatment decision-making. However, no accurate test is currently available. Methods: …
View article: Tumor Detection of <sup>18</sup>F-PSMA-1007 in the Prostate Gland in Patients with Prostate Cancer Using Prostatectomy Specimens as Reference Method
Tumor Detection of <sup>18</sup>F-PSMA-1007 in the Prostate Gland in Patients with Prostate Cancer Using Prostatectomy Specimens as Reference Method Open
Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used with positron emission tomography/computed tomography (PET-CT) are a promising tool for managing patients with prostate cancer. This study aimed to determine the accuracy …
View article: A 23‐Gene Classifier urine test for prostate cancer prognosis
A 23‐Gene Classifier urine test for prostate cancer prognosis Open
Dear Editor, Currently no accurate prognostic test is available to predict prostate cancer (PCa) biochemical recurrence (BCR) after treatment or cancer metastasis.1-7 To address the unmet medical need, we developed a novel 23-Gene Classifi…
View article: An Artificial Intelligence–based Support Tool for Automation and Standardisation of Gleason Grading in Prostate Biopsies
An Artificial Intelligence–based Support Tool for Automation and Standardisation of Gleason Grading in Prostate Biopsies Open
We developed a sensitive artificial intelligence tool for prostate biopsies, which detects and grades cancer with similar accuracy to pathologists. This tool holds promise to improve the diagnosis of prostate cancer.
View article: Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer Open
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration‐resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivatio…
View article: Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase
Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase Open
Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) cells may recruit and utilize bone marrow cells for th…
View article: The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer
The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer Open
Currently, no effective targeted therapeutics exists for treatment of metastatic prostate cancer (PCa). Given that matrix metalloproteinases 9 (MMP9) and its associated vascular endothelial growth factor (VEGF) are critical for tumor vascu…
View article: Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells
Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells Open
One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding-domain, the best characterized of which is AR-V7. We have previously reported th…
View article: Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow Open
Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as a cell of origin for prostate cancer metastasis, the pathways that enable metastatic development at dist…