Athiththan Yogeswaran
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View article: Dual Impacts of Lung Transplantation on the Recovery and Comorbidity of Interstitial Lung Diseases: A Longitudinal Assessment of the Benefits and Burden
Dual Impacts of Lung Transplantation on the Recovery and Comorbidity of Interstitial Lung Diseases: A Longitudinal Assessment of the Benefits and Burden Open
Background: Lung transplantation (LTx) is a life-saving intervention for patients with advanced interstitial lung disease (ILD), markedly improving pulmonary function, exercise capacity, and right heart function, yet it is often accompanie…
View article: Increase in Alveolar Septal Width Is a Histological Predictor of Chronic Lung Allograft Dysfunction and Survival in Lung Transplant Recipients—A Longitudinal Study
Increase in Alveolar Septal Width Is a Histological Predictor of Chronic Lung Allograft Dysfunction and Survival in Lung Transplant Recipients—A Longitudinal Study Open
Background: Chronic lung allograft dysfunction (CLAD) occurs in up to 50% of patients within the first five years after lung transplantation (LuTX) and represents the main complication and cause of death regarding this surgery. Alveolar se…
View article: Method for generating right ventricular pressure-volume loops in routine practice
Method for generating right ventricular pressure-volume loops in routine practice Open
This pressure-based method reconstructs RV PV loops from standard RHC data and reliably estimates SW, contractility, and afterload, supporting its integration into routine clinical workflows (tool freely available at https://pv-loop-genera…
View article: Exercise haemodynamics in pulmonary hypertension – a prospective pressure–volume loop study on right ventricular adaptation and prognosis
Exercise haemodynamics in pulmonary hypertension – a prospective pressure–volume loop study on right ventricular adaptation and prognosis Open
Aims The haemodynamic response to exercise is prognostic in pulmonary hypertension (PH). However, little is known about right ventricular (RV) adaptation in this context. We analysed the patterns and prognostic relevance of RV adaptation t…
View article: Right-sided heart failure in acute respiratory distress syndrome
Right-sided heart failure in acute respiratory distress syndrome Open
Right-sided heart dysfunction (RHD) has emerged as a critical yet often underappreciated aspect of acute respiratory distress syndrome (ARDS). This review describes the role of RHD in ARDS, providing an updated overview of its pathophysiol…
View article: Survival Outcomes and Impact of Targeted PAH Therapy in Portopulmonary Hypertension in the PVRI GoDeep Meta‐Registry
Survival Outcomes and Impact of Targeted PAH Therapy in Portopulmonary Hypertension in the PVRI GoDeep Meta‐Registry Open
Portopulmonary hypertension (PoPH), a type of pulmonary arterial hypertension (PAH) in patients with liver disease, is associated with high morbidity and mortality. The relationship between cardiopulmonary hemodynamics, PAH therapy, and su…
View article: The Diagnostic Accuracy of an Electrocardiogram in Pulmonary Hypertension and the Role of “R V1, V2 + S I, aVL − S V1”
The Diagnostic Accuracy of an Electrocardiogram in Pulmonary Hypertension and the Role of “R V1, V2 + S I, aVL − S V1” Open
Background: Pulmonary hypertension (PH) can cause characteristic electrocardiographic (ECG) changes due to right ventricular hypertrophy and/or strain. The aims of the present study were to explore the diagnostic accuracy of ECG parameters…
View article: SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension
SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension Open
Aims SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N‐terminal pro‐brain natriuretic protein (NT‐proBNP) is an established biomarker of RV failure in…
View article: Right ventricular–pulmonary arterial coupling predicts mortality in precapillary pulmonary hypertension
Right ventricular–pulmonary arterial coupling predicts mortality in precapillary pulmonary hypertension Open
RV-PA coupling, as reflected by the E es/E a ratio, holds substantial clinical relevance and augments the current prognostic assessment in patients with PAH and CTEPD with PH https://bit.ly/4dyKPG…
View article: Loss of right ventricular outflow function in pulmonary hypertension
Loss of right ventricular outflow function in pulmonary hypertension Open
Right ventricular outflow tract (RVOT) function is not systematically quantified by three-dimensional (3D) echocardiography. We tested the hypothesis that loss of RVOT function in pulmonary hypertension (PH) is related to disease severity …
View article: Association of PH-Targeted Therapy and Survival in Precapillary PH with mPAP between 21 and 24 mmHg
Association of PH-Targeted Therapy and Survival in Precapillary PH with mPAP between 21 and 24 mmHg Open
Introduction . Pulmonary hypertension (PH) definition was recently changed and led to a new subset of PH patients with mildly impaired pulmonary hemodynamics, characterized by a mean pulmonary artery pressure of 21–24 mmHg and with a pulmo…
View article: Air travel in patients suffering from pulmonary hypertension—A prospective, multicentre study
Air travel in patients suffering from pulmonary hypertension—A prospective, multicentre study Open
The PEGASUS study is the first multicentric and prospective assessment of the safety of air travel flying in pulmonary hypertension (PH) (NCT03051763). Data of air travel from 60 patients with PH was available. No severe adverse events occ…
View article: Physiological mechanisms behind respiratory variations in right atrial pressure in pulmonary hypertension
Physiological mechanisms behind respiratory variations in right atrial pressure in pulmonary hypertension Open
View article: Native hepatic T1-time as a non-invasive predictor of diastolic dysfunction and a monitoring tool for disease progression and treatment response in patients with pulmonary hypertension
Native hepatic T1-time as a non-invasive predictor of diastolic dysfunction and a monitoring tool for disease progression and treatment response in patients with pulmonary hypertension Open
Hepatic T1-time predicts RV diastolic dysfunction and prognosis, and may be useful for monitoring disease progression and treatment response in PH.
View article: Precision cardiac monitoring: algorithmic real‐time assessment of right ventricular function in pulmonary hypertension
Precision cardiac monitoring: algorithmic real‐time assessment of right ventricular function in pulmonary hypertension Open
Our method simplifies Pmax calculation, requiring only a single point and its slope, unlike previous methods that used multiple points during isovolumetric phases. It should be noted that the original method of Shih et al.4 was described f…
View article: Comparison of Contemporary Risk Scores in All Groups of Pulmonary Hypertension
Comparison of Contemporary Risk Scores in All Groups of Pulmonary Hypertension Open
View article: Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: Validation with invasive pressure-volume analysis
Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: Validation with invasive pressure-volume analysis Open
Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they are substantially load-dependent. Global myocardial w…
View article: A Novel Rat Model of Mild Pulmonary Hypertension Associated with Pulmonary Venous Congestion Induced by Left Pulmonary Vein Banding
A Novel Rat Model of Mild Pulmonary Hypertension Associated with Pulmonary Venous Congestion Induced by Left Pulmonary Vein Banding Open
Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common form of PH. In PH-LHD, changes in the pulmonary vasculature are assumed to be mainly caused by pulmonary venous congestion. However, the underlying …
View article: Liver stiffness is associated with right heart dysfunction, cardiohepatic syndrome, and prognosis in pulmonary hypertension
Liver stiffness is associated with right heart dysfunction, cardiohepatic syndrome, and prognosis in pulmonary hypertension Open
Shear wave liver elastography yields important information regarding right heart function and may complement risk assessment in patients with (suspected) PH.
View article: Native Hepatic T1-Time as a Non-Invasive Predictor of Diastolic Dysfunction and a Monitoring Tool for Disease Progression and Treatment Response in Patients with Pulmonary Hypertension
Native Hepatic T1-Time as a Non-Invasive Predictor of Diastolic Dysfunction and a Monitoring Tool for Disease Progression and Treatment Response in Patients with Pulmonary Hypertension Open
View article: Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: validation with invasive pressure-volume analysis
Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: validation with invasive pressure-volume analysis Open
Background Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they are substantially load-dependent. Global m…
View article: Diagnose Algorithmus der pulmonalen Hypertonie und Screening-Verfahren
Diagnose Algorithmus der pulmonalen Hypertonie und Screening-Verfahren Open
Zusammenfassung Die neuen Leitlinien zur Diagnostik und Therapie der pulmonalen Hypertonie umfassen einen neuen diagnostischen Algorithmus und geben dezidierte Empfehlungen zu den erforderlichen Diagnostiken inklusive Screening-Verfahren a…
View article: Die neue Definition und Klassifikation der pulmonalen Hypertonie
Die neue Definition und Klassifikation der pulmonalen Hypertonie Open
Zusammenfassung In der Neufassung der ESC/ERS-Leitlinien 2022 zur pulmonalen Hypertonie (PH) kam es zu wesentlichen Änderungen in der hämodynamischen Definition sowie zu einer weiteren Verfeinerung in der Klassifikation des Lungenhochdruck…
View article: Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2)
Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2) Open
Zusammenfassung Die pulmonale Hypertonie in Verbindung mit Linksherzerkrankungen (PH-LHD) bildet in der klinischen Klassifikation die Gruppe 2 der pulmonalen Hypertonie ab. Hämodynamisch zählt zu dieser Gruppe die isoliert postkapilläre pu…
View article: Changes in Doppler‐Derived Kidney Venous Flow and Adverse Cardiorenal Outcomes in Patients With Heart Failure
Changes in Doppler‐Derived Kidney Venous Flow and Adverse Cardiorenal Outcomes in Patients With Heart Failure Open
Background The impact of changes in Doppler‐derived kidney venous flow in heart failure (HF) is not well studied. We aimed to investigate the association of Doppler‐derived kidney venous stasis index (KVSI) and intrakidney venous‐flow (IKV…
View article: Hepatorenal dysfunction in patients with chronic thromboembolic pulmonary hypertension
Hepatorenal dysfunction in patients with chronic thromboembolic pulmonary hypertension Open
Background Cardiac interactions with organs such as the liver or kidneys have been described in different cardiovascular diseases. However, the clinical relevance of hepatorenal dysfunction in chronic thromboembolic pulmonary hypertension …
View article: Echocardiographic evaluation of right ventricular diastolic function in pulmonary hypertension
Echocardiographic evaluation of right ventricular diastolic function in pulmonary hypertension Open
Background Right ventricular (RV) diastolic dysfunction may be prognostic in pulmonary hypertension (PH). However, its assessment is complex and relies on conductance catheterisation. We aimed to evaluate echocardiography-based parameters …
View article: Echocardiographic pressure–strain loop‐derived stroke work of the right ventricle: validation against the gold standard
Echocardiographic pressure–strain loop‐derived stroke work of the right ventricle: validation against the gold standard Open
Aims Commercially available integrated software for echocardiographic measurement of stroke work (SW) is increasingly used for the right ventricle, despite a lack of validation. We sought to assess the validity of this method [echo‐based m…
View article: Typisches linksventrikuläres Kontraktionsmuster bei Systemerkrankung
Typisches linksventrikuläres Kontraktionsmuster bei Systemerkrankung Open
View article: Estimated plasma volume status: association with congestion, cardiorenal syndrome and prognosis in precapillary pulmonary hypertension
Estimated plasma volume status: association with congestion, cardiorenal syndrome and prognosis in precapillary pulmonary hypertension Open
Background Volume overload is often associated with clinical deterioration in precapillary pulmonary hypertension (PH). However, thorough assessment of volume overload is complex and therefore not routinely performed. We examined whether e…