Atsuhiko T. Naito
YOU?
Author Swipe
View article: In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance
In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance Open
Although the benefits of β-1 adrenergic receptor (ADRB1) blockade to cardiovascular disease are established, in vivo role for cardiomyocyte ADRB1 remains undetermined. Generating cardiomyocyte-specific ADRB1 knockout mice, we show that ADR…
View article: Laser Speckle Flowgraphy-Based Machine Learning Model Reveals Metabolic Factors Involved in Accelerated Microvascular Aging
Laser Speckle Flowgraphy-Based Machine Learning Model Reveals Metabolic Factors Involved in Accelerated Microvascular Aging Open
View article: Machine Learning Analysis of Ocular Blood Flow for Estimating Vascular Age
Machine Learning Analysis of Ocular Blood Flow for Estimating Vascular Age Open
The process of aging varies among individuals. Some age faster than their true age while others remain more youthful than their chronological age. In this study, we developed machine learning models to predict chronological age using time-…
View article: Development of a Methodology for Showing a Positive Staircase of Contraction in Conventional Two-Dimensional Cell Sheets of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Development of a Methodology for Showing a Positive Staircase of Contraction in Conventional Two-Dimensional Cell Sheets of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Open
ヒト人工多能性幹細胞由来心筋細胞(ヒトiPS細胞由来心筋細胞)の単純二次元細胞シートを多電極プローブ上に作成し,電気ペーシング下で電気生理学的指標を連続記録した状態で薬物を曝露すると,催不整脈リスクおよび抗不整脈作用を検出できる.また同細胞シートの電気刺激位置を工夫すると,生理的な陽性階段現象,すなわち「正の収縮速度-頻度関係」を表出でき,薬物による収縮弛緩運動の変化の評価系としても利用可能である.同細胞シートの収縮速度を十分に引き出すには,プローブに接着した細胞シート中央…
View article: Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study Open
Antiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurpos…
View article: A combination approach of pseudotime analysis and mathematical modeling for understanding drug-resistant mechanisms
A combination approach of pseudotime analysis and mathematical modeling for understanding drug-resistant mechanisms Open
View article: A Combination Approach of Pseudotime Analysis And Mathematical Modeling For Understanding The Drug-Resistant Mechanisms
A Combination Approach of Pseudotime Analysis And Mathematical Modeling For Understanding The Drug-Resistant Mechanisms Open
Cancer cells acquire drug resistance through the following nonresistant, pre-resistant, and resistant stages. Although the molecular mechanism of drug resistance is well investigated, the process of drug resistance acquisition remains larg…
View article: A Combination Approach of Pseudotime Analysis And Mathematical Modeling For Understanding The Drug-Resistant Mechanisms
A Combination Approach of Pseudotime Analysis And Mathematical Modeling For Understanding The Drug-Resistant Mechanisms Open
Cancer cells acquire drug resistance through the following nonresistant, pre-resistant, and resistant stages. Although the molecular mechanism of drug resistance is well investigated, the process of drug resistance acquisition remains larg…
View article: Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes
Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes Open
View article: Mathematical Modeling and Transcriptome Profiling of Breast Cancer Cells During Tamoxifen Treatment Reveal Multiple Trajectories for Resistant Subtypes
Mathematical Modeling and Transcriptome Profiling of Breast Cancer Cells During Tamoxifen Treatment Reveal Multiple Trajectories for Resistant Subtypes Open
Cancer cells acquire drug resistance through following non-resistant, pre-resitant and resistant stages. Although the molecular mechanism of drug resistance is well investigated, the process of drug resistance acquisition remains largely u…
View article: Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion
Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion Open
Contractility of the human heart increases as its beating rate is elevated, so-called positive force-frequency relationship; however, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been reported to exert a nega…
View article: Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure Open
View article: Cardiovascular Safety Tests for the Promotion of Drug Development in Academia
Cardiovascular Safety Tests for the Promotion of Drug Development in Academia Open
Cardiac toxicity is the leading cause of attrition during drug development. International Consortium on Harmonization provides the guideline for evaluating the potential arrhythmogenicity of drug candidates based on in vitro assessment of …
View article: Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings
Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings Open
We investigated the electro-mechanical relationship of human iPS cell-derived cardiomyocyte sheets under arrhythmic condition, which was induced by digitalis intoxication along with the electrical train stimulation (n = 4). We adopted moti…
View article: Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction
Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction Open
Cardiac fibrosis plays an important role in cardiac remodeling after myocardial infarction (MI). The molecular mechanisms that promote cardiac fibrosis after MI are well studied; however, the mechanisms by which the progression of cardiac …
View article: Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity
Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity Open
View article: Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs
Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs Open
We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca2+ uptake may affect cardiac electrophysiological properties in vivo by using caldaret which can decrease SR diastolic Ca2+ leak, enhance SR Ca2+ reuptake and inhibit rev…
View article: Analysis of onset mechanism of drug-induced TdP in LQT3 patient
Analysis of onset mechanism of drug-induced TdP in LQT3 patient Open
Introduction: TdP occurred in LQT3 patient after switching perospirone (PER) to blonanserin (BLO) for her nocturnal delirium. PER blocked α1-adrenoceptors with pA2 of 2.0 ng/mL. While BLO may also have such potential, 1 μg/mL of it can inh…
View article: Electropharmacological effects of multi-ion channel blockers assessed in hiPSC-CMs sheets with MEA system
Electropharmacological effects of multi-ion channel blockers assessed in hiPSC-CMs sheets with MEA system Open
[Purpose] We examined electrophysiological indices of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets in order to quantitatively estimate multichannel blocking actions of bepridil and amiodarone using MEA syst…
View article: Analysis of onset mechanism for lithium carbonate-induced cardiovascular adverse events assessed in the halothane-anesthetized dogs
Analysis of onset mechanism for lithium carbonate-induced cardiovascular adverse events assessed in the halothane-anesthetized dogs Open
Introduction: Lithium has been widely used for the treatment of bipolar disorder.However, several cardiac adverse events have been noticed in patients who were also treated with other drugs in addition to lithium.In the present study, we s…
View article: Motion vector analysis of the line-patterned cardiomyocytes for assessing the toxicity of anticancer drugs on left ventricular function
Motion vector analysis of the line-patterned cardiomyocytes for assessing the toxicity of anticancer drugs on left ventricular function Open
Recent findings highlight the unexpected toxicity of anticancer drugs on left ventricular (LV) function. Nevertheless, a strategy to predict the potential toxicity of drugs on LV function is still limited. In the present study, we develope…
View article: Analysis of proarrhythmic potential of donepezil
Analysis of proarrhythmic potential of donepezil Open
Aim: Proarrhythmic potential of donepezil was analyzed. Methods: Exp.1: We infused 0.1 and 1 mg/kg, i.v. of donepezil hydrochloride to the chronic atrioventricular block dogs (n=4). Exp.2: We infused 0.01, 0.1 and 1 mg/kg, i.v. of the drug…
View article: Analysis of electropharmacological effects of intracellular Ca<sup>2+</sup> handling modulator caldaret on the canine heart
Analysis of electropharmacological effects of intracellular Ca<sup>2+</sup> handling modulator caldaret on the canine heart Open
Since information is lacking regarding how the enhancement of net sarcoplasmic reticulum (SR) Ca2+ uptake may affect cardiac electrophysiological properties in vivo, we analyzed it with caldaret which can decrease SR Ca2+ leak, enhance SR …
View article: Development of <i>microminipigs</i> and their electro-pharmacological characteristics
Development of <i>microminipigs</i> and their electro-pharmacological characteristics Open
In vivo studies are mandatory to confirm whether a principle generated from in vitro experiments can be reproducible under physiological and pathological conditions, which has become difficult to perform under the principles of 3Rs for ani…
View article: <i>In vivo</i> characterization of rate-dependent impact on the QT interval of <i>microminipig</i> assessed by atrial electrical pacing: Development of correction formulae of QT interval
<i>In vivo</i> characterization of rate-dependent impact on the QT interval of <i>microminipig</i> assessed by atrial electrical pacing: Development of correction formulae of QT interval Open
Correction formulae of QT interval were developed for the halothane-anesthetized microminipigs by adopting atrial pacing (n=5), which were compared with Bazett's and Fridericia's formulae for humans, and Van de Water's one for dogs. The co…
View article: Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice
Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice Open
CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake…
View article: Author Correction: Activation of endothelial β-catenin signaling induces heart failure
Author Correction: Activation of endothelial β-catenin signaling induces heart failure Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View article: Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure Open
View article: Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death
Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death Open
View article: Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury Open