Atsuko Matsunaga
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View article: Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis
Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis Open
The development of FGFR1-driven stem cell leukemia and lymphoma syndrome (SCLL) in mouse models is accompanied by an increase in highly heterogenous myeloid derived suppressor cells (MDSCs), which promote immune evasion. To dissect this he…
View article: Association between changes in 6-minute walk distance and usual gait speed and prognosis in patients aged 75 years or older with cardiovascular disease
Association between changes in 6-minute walk distance and usual gait speed and prognosis in patients aged 75 years or older with cardiovascular disease Open
Background/Introduction: The 6-minute walk distance (6MWD) is a useful prognostic factor in patients with cardiovascular disease (CVD), but it may be challenging to assess in the older populations. Usual gait speed (UGS) may offer a simple…
View article: Genomic Analysis Defines Increased Circulating, Monocyte-Derived Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis and Defines a Multigene Signature That Predicts AML Outcomes
Genomic Analysis Defines Increased Circulating, Monocyte-Derived Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis and Defines a Multigene Signature That Predicts AML Outcomes Open
Background: The development of FGFR1-driven stem cell leukemia and lymphoma syndrome (SCLL) is accompanied by an increase in highly heterogenous myeloid derived suppressor cells (MDSCs), which leads to suppression of all immune effector ce…
View article: Association between estimated glomerular filtration rate and prognosis in patients with cardiovascular disease with and without sarcopenia
Association between estimated glomerular filtration rate and prognosis in patients with cardiovascular disease with and without sarcopenia Open
Background/Introduction A low estimated glomerular filtration rate (eGFR) has been identified as a poor prognostic factor in patients with cardiovascular diseases (CVD). Since serum creatinine, which defines eGFR, is a metabolite of skelet…
View article: Disability in activities of daily living before hospitalisation and clinical outcomes following acute-phase rehabilitation in older individuals with cardiovascular disease
Disability in activities of daily living before hospitalisation and clinical outcomes following acute-phase rehabilitation in older individuals with cardiovascular disease Open
Background Older individuals with cardiovascular disease (CVD) frequently complicate disability in activities of daily living (ADLs), defined as needing assistance performing ADLs, which is at risk for further functional decline and higher…
View article: Association between self-care behaviour and multiple frailty domains in older patients with heart failure
Association between self-care behaviour and multiple frailty domains in older patients with heart failure Open
Background/Introduction Heart failure (HF) self-care is important for the effective management of HF, reducing clinical events such as all-cause mortality and hospitalizations. HF self-care behaviours encompass comply with a regimen involv…
View article: Association of 5-times sit-to-stand test with muscle weakness and prognosis in older patients with cardiovascular disease
Association of 5-times sit-to-stand test with muscle weakness and prognosis in older patients with cardiovascular disease Open
Background/Introduction In the elderly with cardiovascular disease (CVD), maintaining muscle strength and physical function is essential for preventing adverse outcomes like falls and hospitalizations. The decline in lower limb strength si…
View article: Cardiac rehabilitation and long-term prognosis in cardiovascular disease patients with cancer history
Cardiac rehabilitation and long-term prognosis in cardiovascular disease patients with cancer history Open
Background Cancer and CVD both tend to cause skeletal muscle mass loss, and their combined effects are associated with a poor prognosis. In response, studies have shown comprehensive cardiac rehabilitation (CR) to be associated with an imp…
View article: Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis
Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis Open
Background Leukemias driven by activated, chimeric FGFR1 kinases typically progress to AML which have poor prognosis. Mouse models of this syndrome allow detailed analysis of cellular and molecular changes occurring during leukemogenesis. …
View article: Frequency of instrumental activities of daily living is associated with objectively measured physical activity in stable patients with cardiovascular disease
Frequency of instrumental activities of daily living is associated with objectively measured physical activity in stable patients with cardiovascular disease Open
Introduction Implementation of instrumental activities of daily living (IADL) has the necessary items for independent living in community-dwelling, which is reported as a relevant factor for better prognosis in patients with cardiovascular…
View article: Participation in outpatient rehabilitation is associated with reduced readmission rates in patients with acute aortic dissection
Participation in outpatient rehabilitation is associated with reduced readmission rates in patients with acute aortic dissection Open
Background Patients with acute aortic dissection (AAD) usually require a restriction of physical activity during hospitalisation, which frequently causes difficulty returning to their daily life. Additionally, the increase in the number of…
View article: Clinical impact of improving sarcopenia through cardiac rehabilitation in patients with heart failure
Clinical impact of improving sarcopenia through cardiac rehabilitation in patients with heart failure Open
Background Sarcopenia is highly prevalent in patients with heart failure (HF) and is associated with a poor prognosis and a low quality of life. On the other hand, cardiac rehabilitation (CR) has improved clinical outcomes in patients with…
View article: Impact of small-airway disease on exercise intolerance and long-term outcomes in patients with heart failure and reduced or preserved ejection fraction
Impact of small-airway disease on exercise intolerance and long-term outcomes in patients with heart failure and reduced or preserved ejection fraction Open
Introduction Exercise intolerance in patients with heart failure (HF) is a strong indicator of a poor prognosis. As the respiratory impairment in HF patients, the small airway is reportedly more susceptible than central airways, which resu…
View article: Trends and outcomes of early rehabilitation in intensive care unit for patients with cardiovascular disease – a cohort study with propensity score-matched analysis
Trends and outcomes of early rehabilitation in intensive care unit for patients with cardiovascular disease – a cohort study with propensity score-matched analysis Open
Background Early rehabilitation in the intensive care unit (ICU), including early mobility therapy, is known to improve the clinical outcomes in patients with critically ill. However, the effectiveness of acute-phase cardiovascular rehabil…
View article: Cancer as a risk factor for physical dysfunction and poor prognosis in patients with cardiovascular disease
Cancer as a risk factor for physical dysfunction and poor prognosis in patients with cardiovascular disease Open
Introduction The emerging interdisciplinary field of cardio-oncology is of interest to clinicians because a history of cancer or cancer treatment is considered a severe risk factor for cardiovascular disease (CVD). Both cancer and CVD can …
View article: Prognostic value of liver damage assessed by direct bilirubin and skeletal muscle weakness in patients with heart failure
Prognostic value of liver damage assessed by direct bilirubin and skeletal muscle weakness in patients with heart failure Open
Background Patients with heart failure (HF) have a high prevalence of liver function abnormalities such as bilirubin abnormalities. However, the relationship between abnormalities of direct bilirubin (DB), a fraction of total bilirubin, an…
View article: Perme ICU Mobility Score as a comprehensive assessment tool of acute-phase rehabilitation is correlated with clinical outcomes in patients after cardiovascular surgery
Perme ICU Mobility Score as a comprehensive assessment tool of acute-phase rehabilitation is correlated with clinical outcomes in patients after cardiovascular surgery Open
Background Early mobility therapy in the intensive care unit (ICU) is widely employed to improve the physical function and prognosis of patients with critically ill. On the other hand, patients who undergo cardiovascular surgery frequently…
View article: Sex differences in frequency of instrumental activities of daily living after cardiac rehabilitation and its impact on long-term mortality in patients with heart failure
Sex differences in frequency of instrumental activities of daily living after cardiac rehabilitation and its impact on long-term mortality in patients with heart failure Open
Introduction While the major outcome of cardiac rehabilitation for heart failure (HF) is the improvement of exercise tolerance, prognosis, and quality of life, instrumental activities of daily living (IADL) has also been focused on as one …
View article: RHOA-regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia
RHOA-regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia Open
The Philadelphia 9;22 chromosome translocation has two common isoforms that are preferentially associated with distinct subtypes of leukemia. The p210 variant is the hallmark of chronic myeloid leukemia (CML) whereas p190 is frequently ass…
View article: Skeletal muscle mass metrics as factors in the prognosis of heart failure patients
Skeletal muscle mass metrics as factors in the prognosis of heart failure patients Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): JSPS KAKENHI Grant Background Sarcopenia is a chronic condition that is characterized by the loss of skeletal muscle mass wit…
View article: Prevalence of metabolic dysfunction-associated fatty liver disease and its association with physical function in patients with acute coronary syndrome
Prevalence of metabolic dysfunction-associated fatty liver disease and its association with physical function in patients with acute coronary syndrome Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): JSPS KAKENHI Background It is widely known that patients with acute coronary syndrome (ACS) are at increased risk of nonalcoh…
View article: Relationship between the spread of coronavirus disease 2019, social frailty and depressive symptoms in patients with heart failure
Relationship between the spread of coronavirus disease 2019, social frailty and depressive symptoms in patients with heart failure Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): the Japan Society for the Promotion of Science (JSPS) KAKENHI Background Owing to the spread of coronavirus disease 2019 (COV…
View article: IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies
IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies Open
Background Stem Cell leukemia/lymphoma syndrome (SCLL) presents as a myeloproliferative disease which can progress to acute myeloid leukemia and is associated with the coincident development of B-cell and T-cell lymphomas. SCLL is driven b…
View article: A splice acceptor variant in <i>HLA</i>‐<i>DRA</i> affects the conformation and cellular localization of the class II DR alpha‐chain
A splice acceptor variant in <i>HLA</i>‐<i>DRA</i> affects the conformation and cellular localization of the class II DR alpha‐chain Open
Summary Class II human leucocyte antigen (HLA) proteins are involved in the immune response by presenting pathogen‐derived peptides to CD4 + T lymphocytes. At the molecular level, they are constituted by α/β‐heterodimers on the surface of …
View article: Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis
Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis Open
Significance Over 200 genomic loci have been found associated with the risk of developing multiple sclerosis (MS). Despite this important body of data, limited information exists on the cellular pathways and molecular mechanisms underlying…