Atsushi Maruyama
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View article: The continued impact of COVID-19 during the Omicron era on immunocompromised individuals in Japan
The continued impact of COVID-19 during the Omicron era on immunocompromised individuals in Japan Open
IC individuals had a high COVID-19 disease burden during the Omicron era. Appropriate preventive measures should be continued for this population.
View article: Evaluation of Plasma microRNA-222 as a Biomarker for Gastric Cancer
Evaluation of Plasma microRNA-222 as a Biomarker for Gastric Cancer Open
Background: The dysregulation of microRNAs (miRNAs) has been detected in patients with gastric cancer (GC), which inspired the use of miRNAs as a novel biomarker for GC. In this study, we investigated the previously reported miRNA dysfunct…
View article: Hidden Markov model analysis to fluorescence blinking of fluorescently labeled DNA
Hidden Markov model analysis to fluorescence blinking of fluorescently labeled DNA Open
We examine quantitatively the transition process from emitting to not-emitting states of fluorescent molecules with a machine learning technique. In a fluorescently labeled DNA, the fluorescence occurs continuously under irradiation, but i…
View article: Clinical characteristics and COVID-19-related outcomes of immunocompromised patients receiving tixagevimab/cilgavimab pre-exposure prophylaxis in Japan
Clinical characteristics and COVID-19-related outcomes of immunocompromised patients receiving tixagevimab/cilgavimab pre-exposure prophylaxis in Japan Open
This is the first report using a multicenter database to describe the clinical characteristics and COVID-19-related outcomes of IC patients administered with tixagevimab/cilgavimab in real-world settings in Japan. This cohort of IC patient…
View article: New year greetings from editors of Drug Delivery System
New year greetings from editors of Drug Delivery System Open
View article: Estimation of Days to Emergence Based on Soil Temperature in Sweet Potato Crops Grown by Direct Planting
Estimation of Days to Emergence Based on Soil Temperature in Sweet Potato Crops Grown by Direct Planting Open
苗を移植する慣行の挿苗栽培と比較して，種いもを直接，圃場に植付ける直播栽培ではカンショ生産に要する労力を削減できる．しかしながら，直播栽培では出芽までに時間を要するため生育初期に雑草害を受けやすい．このため，出芽日を把握して適切に除草作業を計画することが重要となる．本研究では，これまで知見のない直播栽培カンショの出芽予測の端緒とするため，有効積算地温に基づきカンショの出芽までの日数 （出芽日数） が予測できるかを検討した．試験ではカンショ7品種を用いて，2018年と2019…
View article: 2D–3D‐Convertible, pH‐Responsive Lipid Nanosheets
2D–3D‐Convertible, pH‐Responsive Lipid Nanosheets Open
2D nanosheets self‐assembled with amphiphilic molecules are promising tools for biomedical applications; yet, there are challenges to form and stabilize these nanosheets under complex physiological conditions. Here, the development of lipi…
View article: A Cationic Copolymer Enhances Responsiveness and Robustness of DNA Circuits
A Cationic Copolymer Enhances Responsiveness and Robustness of DNA Circuits Open
Toehold‐mediated DNA circuits are extensively employed to construct diverse DNA nanodevices and signal amplifiers. However, operations of these circuits are slow and highly susceptive to molecular noise such as the interference from bystan…
View article: New year greetings from editors of Drug Delivery System
New year greetings from editors of Drug Delivery System Open
View article: Programmed Control of Fluorescence Blinking Patterns based on Electron Transfer in DNA
Programmed Control of Fluorescence Blinking Patterns based on Electron Transfer in DNA Open
Fluorescence imaging uses changes in the fluorescence intensity and emission wavelength to analyze multiple targets simultaneously. To increase the number of targets that can be identified simultaneously, fluorescence blinking can be used …
View article: Label free electrochemical DNA biosensor for COVID-19 diagnosis
Label free electrochemical DNA biosensor for COVID-19 diagnosis Open
View article: Material symbiosis：Orchestration of weak interactions
Material symbiosis：Orchestration of weak interactions Open
View article: Enjoy Volume 2022 of "DDS"
Enjoy Volume 2022 of "DDS" Open
View article: Crystallization-induced mechanofluorescence for visualization of polymer crystallization
Crystallization-induced mechanofluorescence for visualization of polymer crystallization Open
View article: Simple and rapid RNA detection using cationic copolymer-chaperoned MNAzyme (ACEzyme)
Simple and rapid RNA detection using cationic copolymer-chaperoned MNAzyme (ACEzyme) Open
Simple, rapid, and accurate diagnosis is indispensable for broadercontrol measures, search for routes of infection, and understanding treatment status of emerging infectious diseases. Although PCR and LAMP are commonly used, in cases where…
View article: Fanconi syndrome secondary to deferasirox with severe and prolonged urinary potassium loss in a β-thalassemia major patient
Fanconi syndrome secondary to deferasirox with severe and prolonged urinary potassium loss in a β-thalassemia major patient Open
重症 β サラセミアの16 歳女性．輸血後鉄過剰症に対し 13 歳時より経口鉄キレート剤 deferasirox (Def) を開始した．5 か月後に低K，低P，低尿酸血症を認め，P を補充した．14 歳時に同種末梢血幹細胞移植を行った．16 歳時に胃腸炎症状に伴い著明な低K，低P，低尿酸血症，腎性糖尿，低分子蛋白尿を認めDef による Fanconi 症候群と診断し，P に加えてK の補充を開始した．Def を減量したが，4 か月後に代謝性アシドーシスも出現し，Def を…
View article: Ionic polymers to boost biomolecular functions: 20<sup>th</sup> Nagai Award, Japan Society of DDS
Ionic polymers to boost biomolecular functions: 20<sup>th</sup> Nagai Award, Japan Society of DDS Open
View article: An implantable blood clot–based immune niche for enhanced cancer vaccination
An implantable blood clot–based immune niche for enhanced cancer vaccination Open
An implantable blood clot–based cancer vaccine is developed for enhanced cancer immunotherapy.
View article: A case of hepatitis C-related liver cirrhosis treated with lusutrombopag before coil embolization for splenic artery aneurysm
A case of hepatitis C-related liver cirrhosis treated with lusutrombopag before coil embolization for splenic artery aneurysm Open
症例は53歳，女性．両側胸水を契機にC型肝炎を背景とした非代償性肝硬変と診断された．腹部CT検査にて径25 mmの脾動脈瘤を認めたため，治療目的に当院を受診した．受診時，血小板数4.9×104/μlと減少を認めたため，ルストロンボパグの内服を行った．血小板数7.6×104/μlへの上昇を確認し，脾動脈瘤コイル塞栓術を施行した．手技による合併症やルストロンボパグによる重篤な副作用は認めずに経過した．血小板減少症を伴う慢性肝疾患症例の観血的手技施行時において，血小板輸血の代替療…
View article: Frontispiece: Kinetics of Photoinduced Reactions at the Single‐Molecule Level: The KACB Method
Frontispiece: Kinetics of Photoinduced Reactions at the Single‐Molecule Level: The KACB Method Open
The kinetics of photoinduced reactions of fluorescent molecules can be observed by laser flash photolysis techniques. Considering that those techniques require substantial amounts of samples the use for analytical or diagnostic application…
View article: One-step isothermal RNA detection with LNA-modified MNAzymes chaperoned by cationic copolymer
One-step isothermal RNA detection with LNA-modified MNAzymes chaperoned by cationic copolymer Open
View article: Artificial chaperones: From materials designs to applications
Artificial chaperones: From materials designs to applications Open
View article: Effectiveness of Glecaprevir/Pibrentasvir for Hepatitis C: Real-World Experience and Clinical Features of Retreatment Cases
Effectiveness of Glecaprevir/Pibrentasvir for Hepatitis C: Real-World Experience and Clinical Features of Retreatment Cases Open
Glecaprevir/pibrentasvir (G/P) are direct-acting antivirals (DAAs) that achieve a high sustained virological response (SVR) rate for hepatitis C virus (HCV) infection. We investigated G/P effectiveness for HCV patients based on real-world …
View article: The First Known Case of Liver Abscess Caused by <i>Aggregatibacter aphrophilus</i> in Japan
The First Known Case of Liver Abscess Caused by <i>Aggregatibacter aphrophilus</i> in Japan Open
A 48-year-old man presented with a sustained fever. Abdominal computed tomography revealed multilocular liver abscesses. He underwent percutaneous needle aspiration, yielding straw-colored pus. Gram staining revealed Gram-negative coccobac…
View article: Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
Preparation and characterization of gelatin sponge millispheres injectable through microcatheters Open
Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials …
View article: [FOREWORD]Precise design and structural control of polymer materials for DDS
[FOREWORD]Precise design and structural control of polymer materials for DDS Open
View article: [FOREWORD]“Recent progress in “<i>in vivo</i>” imaging and theranostics”
[FOREWORD]“Recent progress in “<i>in vivo</i>” imaging and theranostics” Open
View article: Cover Feature: Fluorescence Redox Blinking Adaptable to Structural Analysis of Nucleic Acids (Chem. Eur. J. 26/2018)
Cover Feature: Fluorescence Redox Blinking Adaptable to Structural Analysis of Nucleic Acids (Chem. Eur. J. 26/2018) Open
By designing patterns of fluorescence blinking, that is, fluctuation in fluorescence intensity, to be affected by the microenvironment around the fluorophore, various fluorophores can be turned into environment-sensitive probes. Nucleice a…
View article: Asymmetricity Between Sister Cells of Pluripotent Stem Cells at the Onset of Differentiation
Asymmetricity Between Sister Cells of Pluripotent Stem Cells at the Onset of Differentiation Open
Various somatic stem cells divide asymmetrically; however, it is not known whether embryonic stem cells (ESCs) divide symmetrically or asymmetrically, not only while maintaining an undifferentiated state but also at the onset of differenti…
View article: Single‐Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking
Single‐Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking Open
Single‐molecule fluorescence resonance energy transfer (smFRET) is a powerful tool to investigate the dynamics of biomolecular events in real time. However, it requires two fluorophores and can be applied only to dynamics that accompany la…