Atsushi Nakajima
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View article: Histological severity and hepatic outcomes in patients with MASLD and discrepant FIB-4 and liver stiffness measurement
Histological severity and hepatic outcomes in patients with MASLD and discrepant FIB-4 and liver stiffness measurement Open
Approximately 30% of patients in tertiary centers exhibit discordant FIB-4 and LSM results, with LSM more likely reflecting true severity. While some patients with discordant results may have advanced fibrosis, the overall incidence of LRE…
View article: Socioeconomic value of treatments for chronic idiopathic constipation in Japan
Socioeconomic value of treatments for chronic idiopathic constipation in Japan Open
View article: Direct comparison of ultrasound-guided attenuation parameter and controlled attenuation parameters for steatosis using MRI-based proton density fat fraction as a reference
Direct comparison of ultrasound-guided attenuation parameter and controlled attenuation parameters for steatosis using MRI-based proton density fat fraction as a reference Open
View article: Efficacy of Drainage Combining Endoscopic Retrograde Cholangiopancreatography With Endoscopic Ultrasound‐guided Biliary Drainage for Difficult‐to‐Control Cholangitis in Patients With Hilar Cholangiocarcinoma
Efficacy of Drainage Combining Endoscopic Retrograde Cholangiopancreatography With Endoscopic Ultrasound‐guided Biliary Drainage for Difficult‐to‐Control Cholangitis in Patients With Hilar Cholangiocarcinoma Open
Objectives Hilar cholangiocarcinoma often results in repeated early stent dysfunction and difficult‐to‐control cholangitis after drainage using endoscopic retrograde cholangiopancreatography (ERCP). In this study, we evaluated the effectiv…
View article: Efficacy of Magnetic Resonance Elastography in Fontan‐Associated Liver Disease
Efficacy of Magnetic Resonance Elastography in Fontan‐Associated Liver Disease Open
Aims Many patients develop Fontan‐associated liver disease (FALD) after undergoing the Fontan procedure—a surgical treatment for congenital heart disease such as single ventricle—owing to changes in venous pressure and cardiac output. Live…
View article: Patients with symptomatic uncomplicated diverticular disease have high fecal bile acid concentrations
Patients with symptomatic uncomplicated diverticular disease have high fecal bile acid concentrations Open
Background and Aim Symptomatic uncomplicated diverticular disease (SUDD) causes persistent pain and impairs patient quality of life; however, its pathogenesis remains unknown. This study investigated the relationship between SUDD and the i…
View article: Tips for Hepatologist Referral of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease with Alanine Aminotransferase Levels ≤ 30 U/L
Tips for Hepatologist Referral of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease with Alanine Aminotransferase Levels ≤ 30 U/L Open
Background/Objectives: The possibility of progressive liver fibrosis remains even when alanine aminotransferase (ALT) levels are <30 IU/L. Therefore, we aimed to investigate factors that can predict fibrosis progression in patients with me…
View article: Utilizing Altmetrics to Track Advancements in Noninvasive Tests for MASLD
Utilizing Altmetrics to Track Advancements in Noninvasive Tests for MASLD Open
Objective Noninvasive tests (NITs) are vital for the early diagnosis of the stage of metabolic dysfunction‐associated steatotic liver disease (MASLD). This study investigates relationships between altmetric scores, traditional Web of Scien…
View article: Ipragliflozin improves the hepatic outcomes of patients with diabetes with NAFLD
Ipragliflozin improves the hepatic outcomes of patients with diabetes with NAFLD Open
Sodium glucose cotransporter-2 inhibitors (SGLT2is) are now widely used to treat diabetes, but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined. We aimed to evaluate the effects of SGLT2is on the pathogenes…
View article: SWOT Analysis of Noninvasive Tests for Diagnosing MASLD with Severe Fibrosis: An Expert Review by the JANIT Forum
SWOT Analysis of Noninvasive Tests for Diagnosing MASLD with Severe Fibrosis: An Expert Review by the JANIT Forum Open
View article: Prior Immune Checkpoint Inhibitor Treatment Is a Risk Factor for Treatment‐Related Adverse Events in Unresectable Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab
Prior Immune Checkpoint Inhibitor Treatment Is a Risk Factor for Treatment‐Related Adverse Events in Unresectable Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab Open
Aims In March 2024, the American Society of Clinical Oncology recommended the combination of tremelimumab plus durvalumab as a treatment for advanced hepatocellular carcinoma (HCC). Although safety data for first‐line treatments are availa…
View article: Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher <scp>AST</scp>/Platelet Ratio Index in Obese Males
Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher <span>AST</span>/Platelet Ratio Index in Obese Males Open
It remains unclear whether alcohol intake and cardiometabolic factors are simultaneously associated with liver fibrosis progression in Japanese obese patients. This study investigated factors influencing liver fibrosis progression using th…
View article: Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects
Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects Open
View article: Usefulness of Detective Flow Imaging EUS in Intra-Abdominal Hypervascular Tumors
Usefulness of Detective Flow Imaging EUS in Intra-Abdominal Hypervascular Tumors Open
: Background/Objectives: Although contrast-enhanced endoscopic ultrasound (CH-EUS) plays an important role in the ultrasound imaging-based diagnosis of intra-abdominal hypervascular tumors, detective flow imaging EUS (DFI-EUS), which can d…
View article: Post‐endoscopic sphincterotomy delayed bleeding occurs in patients with just 1‐day interruption of direct oral anticoagulants or hemodialysis
Post‐endoscopic sphincterotomy delayed bleeding occurs in patients with just 1‐day interruption of direct oral anticoagulants or hemodialysis Open
Objective Endoscopic sphincterotomy (EST), especially when anticoagulants are used, carries a significant risk of delayed bleeding. However, the relationship between the use of antithrombotic agents, including direct oral anticoagulants, a…
View article: A multicenter, postmarketing surveillance of elobixibat in patients with chronic constipation in Japan: A final analysis report
A multicenter, postmarketing surveillance of elobixibat in patients with chronic constipation in Japan: A final analysis report Open
Objective: An interim analysis of postmarketing surveillance reported the safety and efficacy of elobixibat, a laxative medication that inhibits the ileal bile acid transporter, at 4 weeks in approximately 1000 patients with chronic consti…
View article: Microbial Control of 2-Butyl Octanoic Acid Potassium Salt against <i>Acanthamoeba</i> and Bacteria
Microbial Control of 2-Butyl Octanoic Acid Potassium Salt against <i>Acanthamoeba</i> and Bacteria Open
View article: Prediction of Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease by Type IV Collagen 7S
Prediction of Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease by Type IV Collagen 7S Open
View article: Effects of Oral Ingestion of L-Ornithine on Mental Stress and Fatigue Based on the Trier Social Stress Test in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
Effects of Oral Ingestion of L-Ornithine on Mental Stress and Fatigue Based on the Trier Social Stress Test in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial Open
Background: With changes in the social environment typified by COVID-19, an increasing number of people are suffering from mental stress in interpersonal relationships and the resulting fatigue in recent years. L-ornithine oral ingestion r…
View article: Quantitative color analysis of the diets of patients with metabolic dysfunction‐associated steatotic liver disease: Comparative study with nutritionally balanced diets
Quantitative color analysis of the diets of patients with metabolic dysfunction‐associated steatotic liver disease: Comparative study with nutritionally balanced diets Open
Aim The prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD), including its severe subtype, metabolic dysfunction‐associated steatohepatitis (MASH), is increasing worldwide. This condition is a major health concer…
View article: Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease
Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease Open
Background: Various noninvasive tests can be used to identify high-risk groups of patients with metabolic dysfunction–associated steatotic liver disease/steatohepatitis (MASLD). In this study, we compared the diagnostic performance of seru…
View article: Endoscopic ultrasound‐guided fine‐needle biopsy needle can facilitate histological diagnosis of type 1 autoimmune pancreatitis
Endoscopic ultrasound‐guided fine‐needle biopsy needle can facilitate histological diagnosis of type 1 autoimmune pancreatitis Open
Background The choice between 22‐gauge endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) and EUS‐guided fine‐needle aspiration (EUS‐FNA) for histological diagnosis of type 1 autoimmune pancreatitis (AIP) is unclear. We retrospectiv…
View article: Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021
Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021 Open
View article: Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial
Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial Open
View article: Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol
Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol Open
Introduction Non-alcoholic fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a phenotype of the metabolic syndrome in the liver and is clearly associated with metabolic abnormalities suc…
View article: Effects of Ipragliflozin on Skeletal Muscle Adiposity in Patients with Diabetes and Metabolic Dysfunction-associated Steatotic Liver Disease
Effects of Ipragliflozin on Skeletal Muscle Adiposity in Patients with Diabetes and Metabolic Dysfunction-associated Steatotic Liver Disease Open
Objective Myosteatosis affects the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and may be a potential therapeutic target. This study aimed to examine the effects of ipragliflozin (IPR) on myosteatosis i…
View article: Thin Delivery Stents Can Obviate the Need for Additional Fistula Dilatation of Large Diameter in Endoscopic Ultrasound-Guided Hepaticogastrostomy
Thin Delivery Stents Can Obviate the Need for Additional Fistula Dilatation of Large Diameter in Endoscopic Ultrasound-Guided Hepaticogastrostomy Open
Background/Objectives: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) often requires fistula dilation owing to the placement of a large diameter of the delivery stent. The recently developed delivery devices, which are as thin …
View article: Clinical Utility of Genetic Variants in <i>PNPLA3</i> and <i>TM6SF2</i> to Predict Liver‐Related Events in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Clinical Utility of Genetic Variants in <i>PNPLA3</i> and <i>TM6SF2</i> to Predict Liver‐Related Events in Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Background and Aims Fibrosis‐4 (FIB‐4) index and genetic polymorphisms have been used in assessing the risk of liver‐related events (LRE) in metabolic dysfunction‐associated steatotic liver disease (MASLD). To establish a more efficient pr…
View article: Efficacy and safety of linaclotide in treatment‐resistant chronic constipation: A multicenter, open‐label study
Efficacy and safety of linaclotide in treatment‐resistant chronic constipation: A multicenter, open‐label study Open
Background This study aimed to evaluate the efficacy and safety of linaclotide in patients with chronic constipation (CC) or irritable bowel syndrome with constipation (IBS‐C) who did not respond to treatment with magnesium oxide (MgO). Me…
View article: Paradigm shift in steatotic liver disease (SLD): from NAFLD to MASLD
Paradigm shift in steatotic liver disease (SLD): from NAFLD to MASLD Open