Attila Gácser
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View article: Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against <i>Candida parapsilosis</i> colonization
Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against <i>Candida parapsilosis</i> colonization Open
In hematopoietic cell transplant patients, intestinal Candida parapsilosis expansion and translocation cause life-threatening candidemia, yet how commensal intestinal bacteria prevent Candida expansion remains incompletely defined. Here, w…
View article: Nitric Oxide-Releasing Microparticles: A Novel Treatment for Onychomycosis
Nitric Oxide-Releasing Microparticles: A Novel Treatment for Onychomycosis Open
Onychomycosis is one of the most prevalent fungal infections worldwide, resulting in negative effects on general quality of life. Management of the disease encounters a series of obstacles, and antifungal treatment has a low success rate. …
View article: A non-canonical fungal peroxisome PTS-1 signal, SYM, and its evolutionary aspects
A non-canonical fungal peroxisome PTS-1 signal, SYM, and its evolutionary aspects Open
View article: Comprehensive analysis of human keratinocyte interactions with <i>Candida albicans</i> and <i>Candida parapsilosis</i>
Comprehensive analysis of human keratinocyte interactions with <i>Candida albicans</i> and <i>Candida parapsilosis</i> Open
In recent years, microbiome studies have revealed that Candida species are common colonizers of the human skin. The distribution of species, however, varies greatly. Although C. parapsilosis is more likely to resemble skin co…
View article: Early<i>Candida</i>–Oral Tumor Interactions Suggest miRNA-Mediated Regulation of Inflammatory and Tumor-associated processes
Early<i>Candida</i>–Oral Tumor Interactions Suggest miRNA-Mediated Regulation of Inflammatory and Tumor-associated processes Open
When simultaneously present, oral cancer and oral candidiasis are associated with high mortality. Recently, fungi-driven OSCC has emerged as a recognized phenomenon, that is triggered by Candida and sustained by several pro-tumor mechanism…
View article: Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells
Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells Open
Both AuNPs and AgNPs showed a remarkable ability to influence macrophage-cancer cell communication, suppressed indirectly M2-like TAM polarization, and perturbed the migration behavior of TAMs that is critical for tumor invasion, indicatin…
View article: PCR-based CRISPR/Cas9 system for fluorescent tagging: A tool for studying Candida parapsilosis virulence
PCR-based CRISPR/Cas9 system for fluorescent tagging: A tool for studying Candida parapsilosis virulence Open
Candida parapsilosis is persistent in a hospital environment hence it is often associated with nosocomial infections especially amongst low-birth weight neonates. Genetic modification is therefore important to characterise the physiologica…
View article: The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population
The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population Open
The red blood cell (RBC) membrane is unique and crucial for maintaining structural–functional relationships. Maternal smoking induces significant changes in the morphological, rheological, and functional parameters of both maternal and foe…
View article: Shotgun Analysis of Gut Microbiota with Body Composition and Lipid Characteristics in Crohn’s Disease
Shotgun Analysis of Gut Microbiota with Body Composition and Lipid Characteristics in Crohn’s Disease Open
Alterations to intestinal microbiota are assumed to occur in the pathogenesis of inflammatory bowel disease (IBD). This study aims to analyze the association of fecal microbiota composition, body composition, and lipid characteristics in p…
View article: Toll-like receptor 4 (TLR4) is the major pattern recognition receptor triggering the protective effect of a <i>Candida albicans</i> extracellular vesicle-based vaccine prototype in murine systemic candidiasis
Toll-like receptor 4 (TLR4) is the major pattern recognition receptor triggering the protective effect of a <i>Candida albicans</i> extracellular vesicle-based vaccine prototype in murine systemic candidiasis Open
Systemic candidiasis remains a significant public health concern worldwide, with high mortality rates despite available antifungal drugs. Drug-resistant strains add to the urgency for alternative therapies. In this context, vaccination has…
View article: Acquired Triazole Resistance Alters Pathogenicity-Associated Features in Candida auris in an Isolate-Dependent Manner
Acquired Triazole Resistance Alters Pathogenicity-Associated Features in Candida auris in an Isolate-Dependent Manner Open
Fluconazole resistance is commonly encountered in Candida auris, and the yeast frequently displays resistance to other standard drugs, which severely limits the number of effective therapeutic agents against this emerging pathogen. In this…
View article: Antibiotics of the future are prone to resistance in Gram-negative pathogens
Antibiotics of the future are prone to resistance in Gram-negative pathogens Open
Despite the ongoing development of new antibiotics, the future evolution of bacterial resistance may render them ineffective. We demonstrate that antibiotic candidates currently under development are as prone to resistance evolution in Gra…
View article: The IV International Symposium on Fungal Stress and the XIII International Fungal Biology Conference
The IV International Symposium on Fungal Stress and the XIII International Fungal Biology Conference Open
View article: Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
View article: Additional file 5 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 5 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 5. Number of shared LOH blocks > 1 kb between all strains of the different clades.
View article: Additional file 4 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 4 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 4. Summary of the variant calling and LOH blocks analyses for C. orthopsilosis strains after read mapping on the reference genome. Indicated variables as in Additional file 3.
View article: Additional file 17 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 17 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 17. Candida metapsilosis genes overlapping at least one non-synonymous mutation and respective GO terms used in the functional enrichment analysis.
View article: Additional file 24 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 24 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 24: Table S1. Information relative to all C. metapsilosis and C. orthopsilosis strains used in this project, including strain’s name, type of organism, hybridization event, site and place of isolation, genome coverage, numb…
View article: Additional file 16 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 16 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 16. List of essential genes for the occurrence of meiotic recombination, and their respective orthologs in C. orthopsilosis, C. metapsilosis and Clavispora lusitaniae, determined by EggNOG-mapper v1.0.3 using Diamond algori…
View article: Additional file 3 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 3 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 3. Summary of the variant calling and LOH blocks analyses for C. metapsilosis strains after read mapping on the reference genome. The different columns indicate various measured variables in this order, Strain: strain name …
View article: Additional file 7 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 7 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 7. P-values obtained from the hypergeometric test applied to compare the overlap of heterozygous and homozygous regions in each pair of strains or clades.
View article: Additional file 11 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 11 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 11. Summary of the variant calling and LOH blocks analyses for C. orthopsilosis strain s424.
View article: Additional file 18 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 18 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 18. All Candida metapsilosis genes, independently of their overlap with non-synonymous mutations, and respective GO terms used later in the functional enrichment analysis.
View article: Additional file 20 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 20 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 20. All Candida orthopsilosis genes, independently of their overlap with non-synonymous mutations, and respective GO terms used later in the functional enrichment analysis.
View article: Additional file 19 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 19 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 19. Candida orthopsilosis genes overlapping at least one non-synonymous mutation and respective GO terms used in the functional enrichment analysis.
View article: Additional file 10 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 10 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 10. Results of the experimental test of the occurrence of LOH in C. orthopsilosis and C. metapsilosis during mitotic recombination and DNA-break induced repair. Pink, green and blue backgrounds highlight the occurrence of c…
View article: Additional file 14 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 14 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 14. Estimated clade divergence and acquired levels of LOH.
View article: Additional file 13 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 13 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 13. Detected non-reciprocal recombination events in C. orthopsilosis.
View article: Additional file 8 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 8 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 8. List of the PPR proteins analyzed and respective level of homozygosity per strain.
View article: Additional file 12 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Additional file 12 of Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens Open
Additional file 12. Results of the fitness assays of the evolved hybrid strains in comparison to their respective time 0.