Attila Kiss‐Szikszai YOU? Author Swipe

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Regioselective Synthesis of 5-Substituted 3-(β-d-Glycopyranosyl)isoxazoles and -isoxazolines by 1,3-Dipolar Cycloaddition as Potential Anticancer Agents and Glycogen Phosphorylase Inhibitors Open

Tímea Kaszás, Bence Szakács, Márta Bertalan, Tekla Blága, Faria Hameed , et al. · 2025

Anhydro-aldose oximes were employed to generate in situ nitrile oxides via a halogenation/base-induced elimination sequence in the presence of NCS and Et3N, which were then used in 1,3-dipolar cycloadditions with alkenes and alkynes to aff…

Stereoselective Synthesis of Axially Chiral 5,5′-Linked bis-1-Arylisochromans with Antibacterial Activity Open

Zoltán Czenke, Attila Mándi, Gergely Miklós Fedics, Roland A. Barta, Attila Kiss‐Szikszai , et al. · 2025

Inspired by naturally occurring bis-isochromans such as penicisteckins, we envisaged the first synthesis of biaryl-type bis-1-arylisochromans containing a stereogenic ortho-trisubstituted biaryl axis. We achieved the stereoselective synthe…

Knoevenagel-IMHDA and -IMSDA sequences for the synthesis of chiral condensed O,N-, S,N- and N-heterocycles Open

Mihály Kajtár, Sándor Balázs Király, Attila Bényei, Attila Kiss‐Szikszai, Anita Kónya-Ábrahám , et al. · 2025

Heterocycles containing hexahydrobenzo[ j ]phenanthridine and hexahydro-1 H -(thio)pyrano[3,4- c ]pyridine skeletons were prepared by domino Knoevenagel-styryl Diels–Alder and intramolecular hetero-Diels–Alder sequences, respectively.

Development and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel Open

Péter Takács, Barbara Kozma, Dávid Rátonyi, Bence Kozma, Attila Kiss‐Szikszai , et al. · 2024

Genitourinary syndrome of menopause (GSM) affects a significant percentage of postmenopausal women and manifests as vaginal dryness, irritation, and urinary discomfort, typically treated with vaginal estrogens. Hydrogels are preferred over…

VCD Analysis of Axial Chirality in Synthetic Stereoisomeric Biaryl-Type bis-Isochroman Heterodimers with Isolated Blocks of Central and Axial Chirality Open

Zoltán Czenke, Attila Mándi, Sándor Balázs Király, Attila Kiss‐Szikszai, Anita Kónya-Ábrahám , et al. · 2024

Optically active heterodimeric 5,5′-linked bis-isochromans, containing a stereogenic ortho-trisubstituted biaryl axis and up to four chirality centers, were synthesized stereoselectively by using a Suzuki–Miyaura biaryl coupling reaction o…

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity Open

Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde‐Zita Illyés, Andrea Medeiros , et al. · 2024

CCDC 2210410: Experimental Crystal Structure Determination Open

Sándor Balázs Király, László Tóth, Tibor Kovács, Attila Bényei, Erika Lisztes , et al. · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2210409: Experimental Crystal Structure Determination Open

Sándor Balázs Király, László Tóth, Tibor Kovács, Attila Bényei, Erika Lisztes , et al. · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2210411: Experimental Crystal Structure Determination Open

Sándor Balázs Király, László Tóth, Tibor Kovács, Attila Bényei, Erika Lisztes , et al. · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2210408: Experimental Crystal Structure Determination Open

Sándor Balázs Király, László Tóth, Tibor Kovács, Attila Bényei, Erika Lisztes , et al. · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Front Cover Picture: Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2<i>H</i>‐Chromenes and Chromans (Adv. Synth. Catal. 19/2023) Open

Sándor Balázs Király, László Tóth, Tibor Kovács, Attila Bényei, Erika Lisztes , et al. · 2023

The front cover illustrates the diastereoselective formation of condensed heterocyclic ring systems by domino reaction sequences. The dominoes toppling each other represent the steps of the reaction sequences, each transformation initiatin…

Antifungal Activity of Glucosinolate-Derived Nitriles and Their Synergistic Activity with Glucosinolate-Derived Isothiocyanates Distinguishes Various Taxa of Brassicaceae Endophytes and Soil Fungi Open

Zsolt Szűcs, Tamás Plaszkó, Eszter Bódor, Hajnalka Csoma, Lajos Ács-Szabó , et al. · 2023

The glucosinolates of Brassicaceae plants are converted into bioactive isothiocyanates and other volatiles during a challenge by pathogens and other biotic stressors. However, the role of alternative downstream products with weaker potency…

Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles Open

Thinh To Quoc, Krisztina Bíró, Ágota Pető, Dóra Kósa, Dávid Sinka , et al. · 2023

Nasal drug delivery has been a focus of scientific interest for decades. A number of drug delivery systems and devices are available and have been highly successful in providing better and more comfortable therapy. The benefits of nasal dr…

Quality-controlled LC-ESI-MS food metabolomics of fenugreek (Trigonella foenum-graecum) sprouts: Insights into changes in primary and specialized metabolites Open

Sándor Gonda, Zsolt Szűcs, Tamás Plaszkó, Zoltán Cziáky, Attila Kiss‐Szikszai , et al. · 2022

Fenugreek (Trigonella foenum-graecum L.) is an important food and spice with bioactive compounds against diabetes. In this study, fenugreek seeds germinating in darkness for 72 h were studied using quantification of trigonelline and 4-hydr…

Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS) Open

Dávid Sinka, Enikő Doma, Nóra Szendi, Jázmin Páll, Dóra Kósa , et al. · 2022

Fenugreek is used as a spice and a traditional herbal medicine for a variety of purposes, given its antidiabetic and antioxidant effects. Self-emulsifying drug delivery systems (SEDDS) of herbal drugs are targets of extensive research aimi…

Basic Pharmacological Characterization of EV-34, a New H2S-Releasing Ibuprofen Derivative Open

Alexandra Gyöngyösi, Vivien Verner, Ilona Bereczki, Attila Kiss‐Szikszai, Rita Zilinyi , et al. · 2021

Background: Cardioprotective effects of H2S are being suggested by numerous studies. Furthermore, H2S plays a role in relaxation of vascular smooth muscle, protects against oxidative stress, and modulates inflammation. Long-term high-dose …

Synthesis and HPLC-ECD Study of Cytostatic Condensed O,N-Heterocycles Obtained from 3-Aminoflavanones Open

Ádám Szappanos, Attila Mándi, Katalin Gulácsi, Erika Lisztes, Balázs István Tóth , et al. · 2020

Racemic chiral O,N-heterocycles containing 2-arylchroman or 2-aryl-2H-chromene subunit condensed with morpholine, thiazole, or pyrrole moieties at the C-3-C-4 bond were synthesized with various substitution patterns of the aryl group by th…

[1,5]-Hydride Shift-Cyclization versus C(sp2)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines Open

Dóra Szalóki Vargáné, László Tóth, Balázs Buglyó, Attila Kiss‐Szikszai, Attila Mándi , et al. · 2020

Domino cyclization reactions of N-aryl-1,4- and 1,5-benzoxazepine derivatives involving [1,5]-hydride shift or C(sp2)-H functionalization were investigated. Neuroprotective and acetylcholinesterase activities of the products were studied. …

Chemotyping of terrestrial Nostoc-like isolates from alkali grassland areas by non-targeted peptide analysis Open

Milán Riba, Attila Kiss‐Szikszai, Sándor Gonda, Péter Parizsa, Balázs Déak , et al. · 2020

The Nostoc genus is a well-known heterocytous, filamentous cyanobacterium which can be found all over the world. The size of terrestrial and/or freshwater colonies can be microscopic and macroscopic as well. In addition, Nostoc species are…

Comparative metabolomics of Tilia platyphyllos Scop. bracts during phenological development Open

Zsolt Szűcs, Zoltán Cziáky, Attila Kiss‐Szikszai, L Sinka, Gábor Vasas , et al. · 2019

The medicinal plant drug "Tiliae flos" consists of the botanical flowers and bracts of Tilia sp., gathered almost exclusively during flowering. In this study, we examined the changes in the metabolome of specialized products in the bracts …

Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp Open

Milán Riba, Attila Kiss‐Szikszai, Sándor Gonda, Gergely Boros, Zoltán Vitál , et al. · 2019

Most cyanobacterial organisms included in the genus Microcystis can produce a wide repertoire of secondary metabolites. In the mid-2010s, summer cyanobacterial blooms of Microcystis sp. occurred regularly in Lake Balaton. During this perio…

1,2-Dihydrochromeno[2,3-c]pyrrol-3-one Derivatives: Synthesis and HPLC-ECD Analysis Open

László Tóth, Attila Kiss‐Szikszai, Gábor Vasvári, Ferenc Fenyvesi, Miklós Vecsernyés , et al. · 2019

Ethyl-3-formyl-6-methoxy-(2H)-chromene-2-carboxylate was transformed to N-substituted 1,2-dihydrochromeno[2,3-c]pyrrol-3-ones in a domino reductive amination–lactamization reaction. Isomerization of the double bond and the inherently labil…

Allyl-Isothiocyanate and Microcystin-LR Reveal the Protein Phosphatase Mediated Regulation of Metaphase-Anaphase Transition in Vicia faba Open

Tamás Garda, Zoltán Kónya, Csongor Freytag, Ferenc Erdődi, Sándor Gonda , et al. · 2018

Horseradish allyl isothiocyanate (AITC, a volatile oil) and cyanobacterial microcystin-LR (MCY-LR, a cyclic heptapeptide) affect eukaryotic cell cycle. MCY-LR inhibits protein phosphatases PP1 and PP2A. We aimed to reveal the mechanisms of…

Synthesis, In Vitro Biological Evaluation, and Oxidative Transformation of New Flavonol Derivatives: The Possible Role of the Phenyl-N,N-Dimethylamino Group Open

Péter Szabados-Fürjesi, Dávid Pajtás, Aliz Barta, Evelin Csépányi, Attila Kiss‐Szikszai , et al. · 2018

Six new flavonols (6a–f) were synthesized with Claisen–Schmidt and Suzuki reactions and they were fully characterized by spectroscopic methods. In order to evaluate their antioxidant activities, their oxygen radical absorption capacity and…

A Simple Method for On-Gel Detection of Myrosinase Activity Open

Sándor Gonda, Zsolt Szűcs, Tamás Plaszkó, Zoltán Cziáky, Attila Kiss‐Szikszai , et al. · 2018

Myrosinase is an enzyme present in many functional foods and spices, particularly in Cruciferous vegetables. It hydrolyses glucosinolates which thereafter rearrange into bioactive volatile constituents (isothiocyanates, nitriles). We aimed…

HPLC‐ECD and TDDFT‐ECD study of hexahydropyrrolo[1,2‐a]quinoline derivatives Open

László Tóth, Attila Mándi, Dániel Váradi, Tibor Kovács, Anna Szabados , et al. · 2018

Synthesis of racemic hexahydropyrrolo[1,2‐a]quinoline derivatives ( 1 ‐ 8 ) was performed by utilizing the Knoevenagel‐[1,5]‐hydride shift‐cyclization domino reaction. Separation of the enantiomers of the chiral products ( 1 ‐ 8 ) was carr…

Endophytic fungi from the roots of horseradish (Armoracia rusticana) and their interactions with the defensive metabolites of the glucosinolate - myrosinase - isothiocyanate system Open

Zsolt Szűcs, Tamás Plaszkó, Zoltán Cziáky, Attila Kiss‐Szikszai, Tamás Emri , et al. · 2018

Egyszerű gél-előhívási módszer mirozináz enzimaktivitás detektálásához Open

Tamás Plaszkó, Zsolt Szűcs, Zoltán Cziáky, Attila Kiss‐Szikszai, Gábor Vasas , et al. · 2018

Antioxidant Properties and Oxidative Transformation of Different Chromone Derivatives Open

Evelin Csépányi, Péter Szabados-Fürjesi, Attila Kiss‐Szikszai, Lisa M. Frensemeier, Uwe Kärst , et al. · 2017

Nowadays, there is an increase in the application of natural products for the prevention of different disorders or adjuvant substances next to pharmacological treatment. Phytochemicals include different chromone derivatives, which possess …

The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation Open

Klaudia Dócs, Zoltán Mészár, Sándor Gonda, Attila Kiss‐Szikszai, Krisztina Holló , et al. · 2017

Endocannabinoids are pleiotropic lipid messengers that play pro-homeostatic role in cellular physiology by strongly influencing intracellular Ca²⁺ concentration through the activation of cannabinoid receptors. One of the best-kn…

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