Atul Malhotra
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View article: Time-restricted eating improves intermittent hypoxia-induced dysglycemia
Time-restricted eating improves intermittent hypoxia-induced dysglycemia Open
Study objectives Obstructive sleep apnea (OSA) is associated with maladaptive changes to glucose homeostasis. Chronic intermittent hypoxia (IH) modeling OSA in rodents causes similar patterns of dysglycemia. Time-restricted eating (TRE), l…
View article: Deep Learning for Time-Series Segmentation of Mechanical Ventilator Waveforms
Deep Learning for Time-Series Segmentation of Mechanical Ventilator Waveforms Open
Accurate segmentation of ventilator waveforms is essential for detecting patient–ventilator asynchronies (PVAs), yet current heuristic methods can fail in noisy, real-world data. We developed and validated a deep learning model using a one…
View article: Dose–response relationship of sleep apnea therapy and healthcare use in patients with comorbidities
Dose–response relationship of sleep apnea therapy and healthcare use in patients with comorbidities Open
Study Objectives Obstructive sleep apnea (OSA) has complex interactive relationships with several other conditions. Previous research suggests that consistent adherence to positive airway pressure (PAP) therapy can reduce healthcare resour…
View article: Treatment Preferences For Comorbid Obesity and Obstructive Sleep Apnea (PRO-CON OSA) Survey: Patient and Provider Preferences for CPAP and/or Tirzepatide
Treatment Preferences For Comorbid Obesity and Obstructive Sleep Apnea (PRO-CON OSA) Survey: Patient and Provider Preferences for CPAP and/or Tirzepatide Open
Purpose: Approximately one of ten US adults has comorbid obesity and obstructive sleep apnea (COBOSA). Traditionally, sleep medicine management of COBOSA focused on continuous positive airway pressure (CPAP). Recently, tirzepatide (a once-…
View article: Harmonizing late‐life cognitive performance data across two population‐based cohort studies: The Health and Retirement Study and National Health and Aging Trends Study
Harmonizing late‐life cognitive performance data across two population‐based cohort studies: The Health and Retirement Study and National Health and Aging Trends Study Open
INTRODUCTION Harmonizing cognitive measures across population‐based studies facilitates direct comparisons of cognitive decline despite differing study protocols. METHODS Cognitive performance data from 2012–2022 were harmonized across the…
View article: Procedural learning worsens with OSA severity in older adults and is insensitive to short exposure supplemental oxygen therapy
Procedural learning worsens with OSA severity in older adults and is insensitive to short exposure supplemental oxygen therapy Open
As in younger adults, more severe sleep apnea is associated with worse motor procedural learning in older adults. However, a single night of NOS treatment had no effect on procedural learning, suggesting that OSA-related cognitive deficits…
View article: Effects of Treating Obstructive Sleep Apnea on Common Symptoms of HIV
Effects of Treating Obstructive Sleep Apnea on Common Symptoms of HIV Open
Background: Even with modern therapy, people living with HIV (PLWH) commonly experience fatigue and face increased risk of cardiovascular disease. Obstructive sleep apnea (OSA) is common in PLWH and might contribute to these symptoms, yet …
View article: Cord blood-derived cell therapies for preterm brain injury
Cord blood-derived cell therapies for preterm brain injury Open
Preterm birth, defined as delivery before 37 weeks of gestation, remains a leading contributor to neonatal morbidity and long-term neurodevelopmental impairments. Brain injuries such as intraventricular haemorrhage, white matter injury and…
View article: Comparative Analysis of Risk and Liabilities in Contract of Bailment Vs. Sale of Goods Act
Comparative Analysis of Risk and Liabilities in Contract of Bailment Vs. Sale of Goods Act Open
Intending to offer a comprehensive comparative analysis of risk and liabilities in contracts of bailment and contracts governed by the Sales of Goods Act and the Indian Contract Act 1872, this research paper aims to analyse the topic menti…
View article: Enhancing Predictive Modeling for Respiratory Support with LLM-Driven Guideline Adherence
Enhancing Predictive Modeling for Respiratory Support with LLM-Driven Guideline Adherence Open
Background Optimal respiratory support selection between high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) for intensive care units (ICU) patients at risk of invasive mechanical ventilation (IMV) remains unclear, particularl…
View article: Effect of tirzepatide treatment on patient-reported outcomes among SURMOUNT-OSA participants with obstructive sleep apnea and obesity
Effect of tirzepatide treatment on patient-reported outcomes among SURMOUNT-OSA participants with obstructive sleep apnea and obesity Open
NCT05412004.
View article: The role of confidence, motivation, and social support in PAP usage in obstructive sleep apnea: A real-world data analysis
The role of confidence, motivation, and social support in PAP usage in obstructive sleep apnea: A real-world data analysis Open
Study Objectives Despite the well-established benefits of positive airway pressure (PAP) therapy in obstructive sleep apnea (OSA), adoption and persistence rates vary widely. Self-efficacy, motivation and social support may be important be…
View article: Narcolepsy and risk of cardiovascular outcomes beyond stimulant use
Narcolepsy and risk of cardiovascular outcomes beyond stimulant use Open
Study Objectives We aimed to assess associations between narcolepsy and cardiovascular disease risk while accounting for stimulant use in clinical practice. Methods Using 2005–2021 MarketScan Commercial and Medicare Supplemental databases,…
View article: Mortality and antibiotic timing in deep learning-derived surviving sepsis campaign risk groups: a multicenter study
Mortality and antibiotic timing in deep learning-derived surviving sepsis campaign risk groups: a multicenter study Open
Background The current Surviving Sepsis Campaign (SSC) guidelines provide recommendations on timing of administering antibiotics in sepsis patients based on probability of sepsis and presence of shock. However, there have been minimal effo…
View article: Adherence to Positive Airway Pressure Therapy and Healthcare Resource Utilization and Costs Among Patients with Obstructive Sleep Apnea and Obesity
Adherence to Positive Airway Pressure Therapy and Healthcare Resource Utilization and Costs Among Patients with Obstructive Sleep Apnea and Obesity Open
Objective: Obstructive sleep apnea (OSA) and obesity are highly prevalent comorbid conditions associated with major societal and healthcare burden. Positive airway pressure (PAP) therapy is the first-line treatment for OSA. This study eval…
View article: Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the <scp>SNOOzzzE</scp> cohort
Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the <span>SNOOzzzE</span> cohort Open
The overlap syndrome ( OVS ), defined as coexisting chronic obstructive pulmonary disease ( COPD ) and obstructive sleep apnea ( OSA ), is linked to worse outcomes than either condition alone. Patients with COPD and OSA may have fewer obst…
View article: Quantifying Healthcare Provider Perceptions of a Novel Deep Learning Algorithm to Predict Sepsis: Electronic Survey
Quantifying Healthcare Provider Perceptions of a Novel Deep Learning Algorithm to Predict Sepsis: Electronic Survey Open
IMPORTANCE: Sepsis is a major cause of morbidity and mortality, with early intervention shown to improve outcomes. Predictive modeling and artificial intelligence (AI) can aid in early sepsis recognition, but there remains a gap between al…
View article: Safety and Immediate Efficacy of Pulmonary Thromboendarterectomy for Chronic Thromboembolic Disease
Safety and Immediate Efficacy of Pulmonary Thromboendarterectomy for Chronic Thromboembolic Disease Open
Pulmonary thromboendarterectomy is safe and well-tolerated in patients with CTED, improving pulmonary hemodynamics and pulmonary artery compliance.
View article: 1347 Impact of Comorbid Obstructive Sleep Apnea on Pharmacological Treatment Selection for Type 2 Diabetes Mellitus
1347 Impact of Comorbid Obstructive Sleep Apnea on Pharmacological Treatment Selection for Type 2 Diabetes Mellitus Open
Introduction Obstructive sleep apnea (OSA) is highly comorbid with type-2 diabetes mellitus (T2DM). Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) are both considered first-lin…
View article: 0640 Racial and Ethnic Disparities in the Diagnosis and Treatment of Obstructive Sleep Apnea in Middle-Aged and Older Adults
0640 Racial and Ethnic Disparities in the Diagnosis and Treatment of Obstructive Sleep Apnea in Middle-Aged and Older Adults Open
Introduction Racial and ethnic disparities exist in the prevalence of obstructive sleep apnea (OSA); however, research on racial and ethnic differences in the diagnosis and treatment of OSA in older populations is limited. We examined whet…
View article: 1123 Risk of Cardiometabolic Outcomes in Individuals with Type 1 and Type 2 Narcolepsy
1123 Risk of Cardiometabolic Outcomes in Individuals with Type 1 and Type 2 Narcolepsy Open
Introduction Narcolepsy, a chronic neurological sleep disorder, has two subtypes: type 1 (NT1), characterized by cerebrospinal fluid (CSF) orexin deficiency, and type 2 (NT2), characterized by normal CSF orexin levels. Both subtypes share …
View article: 0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea
0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea Open
Introduction Proximal hypoglossal nerve stimulation (pHGNS) has been shown in the THN3 randomized, controlled trial to produce durable three-year improvements in quality of life, oxygenation, and sleep-disordered breathing (Apnea-Hypopnea …
View article: 0718 Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe OSA: OSPREY Randomized Controlled Trial
0718 Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe OSA: OSPREY Randomized Controlled Trial Open
Introduction Clinically significant improvement of the total Apnea-hypopnea index (AHI) in the OSPREY randomized, controlled trial (RCT) of proximal hypoglossal nerve stimulation (pHGNS) was demonstrated for patients receiving active treat…