Atul Pranay
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View article: PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization
PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization Open
Background The heart’s constant energy demands make metabolic flexibility critical to its function as nutrient availability varies. The enzyme phosphofructokinase‐2/fructose 2,6‐bisphosphatase (PFKFB2) contributes to this flexibility by ac…
View article: The Identification of a Key Regulator of Mitochondrial Metabolism, the LRPPRC Protein, as a Novel Therapeutic Target in SDHA-Overexpressing Ovarian Tumors
The Identification of a Key Regulator of Mitochondrial Metabolism, the LRPPRC Protein, as a Novel Therapeutic Target in SDHA-Overexpressing Ovarian Tumors Open
Background: Ovarian cancer is the deadliest of all gynecologic malignancies due to limited therapeutic options. Our data show that the tumor-specific metabolism of ovarian cancer could be effectively targetable, which highlights a path for…
View article: PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization
PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization Open
Background The heart’s constant energy demands make metabolic flexibility critical to its function as nutrient availability varies. The enzyme phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB2) contributes to this flexibility by ac…
View article: Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity
Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity Open
The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin sensitive tissues and cancer. Here, we so…
View article: Identification of a Key Regulator of Mitochondrial Metabolism, the Lrpprc Protein as a Novel Therapeutic Target in Sdha Overexpressing Ovarian Tumors
Identification of a Key Regulator of Mitochondrial Metabolism, the Lrpprc Protein as a Novel Therapeutic Target in Sdha Overexpressing Ovarian Tumors Open
Ovarian cancer is the deadliest of all gynecologic malignancies due to limited therapeutic options. Our data show that tumor-specific metabolism of ovarian cancer could be effectively targetable, which highlights a path for new anti-cancer…
View article: Glycolytic Metabolic Differences Influence Skeletal Muscle Regeneration Following Injury
Glycolytic Metabolic Differences Influence Skeletal Muscle Regeneration Following Injury Open
View article: The effect of enhanced glycolysis on cardiac aging
The effect of enhanced glycolysis on cardiac aging Open
View article: Sulforaphane acutely activates multiple starvation response pathways
Sulforaphane acutely activates multiple starvation response pathways Open
Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables that has demonstrated anti-cancer, anti-microbial and anti-oxidant properties. SFN ameliorates various disease models in rodents (e.g., cancer, diabetes, seizures)…
View article: Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity
Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity Open
The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin sensitive tissues and cancer. Here, we so…
View article: Investigating Metabolic Profiles in Mouse Skeletal Muscle Regeneration
Investigating Metabolic Profiles in Mouse Skeletal Muscle Regeneration Open
View article: Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart
Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart Open
Background Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFK‐2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK‐2, is d…
View article: 17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice
17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice Open
Using a multiomics approach, we show that 17α-E2 alleviates HFD-induced metabolic detriments in skeletal muscle by altering bioactive lipid intermediates, inflammatory cytokines, and the abundance of proteins related to lipolysis and muscl…
View article: Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart
Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart Open
Background Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK-2, is d…
View article: 17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice
17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice Open
Skeletal muscle has a central role in maintaining metabolic homeostasis. 17α-estradiol (17α-E2), a naturally-occurring non-feminizing diastereomer of 17β-estradiol that demonstrates efficacy for improving metabolic outcomes in male, but no…
View article: Skeletal and cardiac muscle have different protein turnover responses in a model of right heart failure
Skeletal and cardiac muscle have different protein turnover responses in a model of right heart failure Open
View article: Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction
Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction Open
Dietary sulfur amino acid restriction (SAAR) protects against diet-induced obesity, extends healthspan, and coincides with an overall reduction in hepatic protein synthesis. To explore the underpinnings of SAAR-induced slowed growth and it…
View article: The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner
The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner Open
SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a cardiac-specific phenotype. Here, we sought to determine how s…