Aude Dorison
YOU?
Author Swipe
View article: Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury
Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury Open
Background We have previously reported that the gap junction protein connexin 43 (Cx43) was upregulated in chronic renal disease in humans and rodents and plays a crucial role in the progression of experimental nephropathy. In this study, …
View article: Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking
Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking Open
Significance Statement Missense variants of NPHS2 that cause mistrafficking of the encoded protein, PODOCIN, have been associated with steroid-resistant nephrotic syndrome. However, most studies have overexpressed such variants in 2D nonpo…
View article: Additional file 3 of DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
Additional file 3 of DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets Open
Additional file 3. This file contains Table S2.
View article: Additional file 2 of DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
Additional file 2 of DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets Open
Additional file 2. This file contains Table S1A-B.
View article: Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis
Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis Open
Significance Statement Podocytes are critical to maintaining the kidney glomerular filtration barrier. Mutations in genes associated with development of nephrotic syndrome lead to elevated cytoplasmic calcium in podocytes and cause disrupt…
View article: DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets Open
Kidney organoids provide a valuable resource to understand kidney development and disease. Clustering algorithms and marker genes fail to accurately and robustly classify cellular identity between human pluripotent stem cell (hPSC)-derived…
View article: Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI
Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI Open
Significance Statement Studies in animal models and human biopsy specimens have associated the matricellular protein periostin with CKD progression, but its role in AKI is unknown. To investigate periostin’s role in AKI in an ischemia-repe…
View article: Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673)
Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673) Open
Edits have been made to Development (2019) 146, dev178673 (doi:10.1242/dev.178673) to clarify that statements made comparing this and previous studies relate to the published analyses of data within those studies and not the detection of g…
View article: Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury Open
Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play key roles in heart repair, regeneration and disease, including fibroblast, vascular and immune cells. However, a comprehensive understanding of thi…
View article: Author response: Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Author response: Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Besides cardiomyocytes (CM), …
View article: DDR1: A major player in renal diseases
DDR1: A major player in renal diseases Open
Discoidin Domain Receptor 1 (DDR1) belongs to a family of two non-integrin collagen receptors, DDR1 and DDR2, which display a tyrosine kinase activity. DDR1 has been widely studied in different kind of pathologies including chronic kidney …
View article: The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease
The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease Open
Discoidin domain receptors (DDRs) are a family of 2 non-integrin collagen receptors, DDR1 and DDR2, which display a tyrosine kinase activity. They are mainly expressed during embryonic development and their role during adulthood is very li…