Aude Ingels
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Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity Open
Amphiphilic ruthenium and osmium complexes auto-assemble to nanosystems that poison mitochondria and show highly promising in vitro and in vivo anticancer activity.
Self-assembled ruthenium and osmium nanosystems display potent anticancer profile by interfering with metabolic activity Open
We disclose novel amphiphilic ruthenium and osmium complexes that auto-assemble into nanomedicines with potent antiproliferative activity by inhibition of mitochondrial respiration. The self-assembling units were rationally designed from t…
Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite Open
The degradation of the fungal metabolite sphaeropsidin A, under physiological conditions, was investigated and the structure of the major degradation product determined.
Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues Open
A new diacylguanidine, actinofide (1), has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and …
Natural and Synthetic Furanones with Anticancer Activity Open
This paper describes the enantioselective synthesis of analogues of sapinofuranones A and B, namely 5-substitutes dihydro- and 5 H-furan-ones, and their in vitro growth inhibitory activity against six cancer cell lines in comparison with f…