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View article: Morphological profiling of human T and NK lymphocytes by high-content cell imaging
Morphological profiling of human T and NK lymphocytes by high-content cell imaging Open
The immunological synapse is a complex structure that decodes stimulatory signals into adapted lymphocyte responses. It is a unique window to monitor lymphocyte activity because of development of systematic quantitative approaches. Here we…
View article: Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium
Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium Open
Intestinal organoids are self-organized 3-dimensional (3D) structures formed by a single layer of polarized epithelial cells. This innovative in vitro model is highly relevant to study physiology of the intestinal epithelium and its role i…
View article: Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR
Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR Open
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View article: Reconstitution of intestinal stem cell niche<i>in vitro</i>with pharmacological inhibitors or L-WRN conditioned medium differentially regulates epithelial proliferation, differentiation and barrier function in rabbit caecum organoids
Reconstitution of intestinal stem cell niche<i>in vitro</i>with pharmacological inhibitors or L-WRN conditioned medium differentially regulates epithelial proliferation, differentiation and barrier function in rabbit caecum organoids Open
Intestinal organoids are self-organized 3-dimensional (3D) structures formed by a single layer of polarized epithelial cells. This innovative in vitro model is highly relevant to study physiology of the intestinal epithelium and its role i…
View article: Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse
Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse Open
The detection and neutralization of infected cells and tumors by cytotoxic lymphocytes is a vital immune defense mechanism. The immunological synapse orchestrates the target recognition process and the subsequent cytotoxic activity. Here, …
View article: GermanVulliard2021
GermanVulliard2021 Open
This dataset contains the CellProfiler pipelines and the corresponding morphological measurements used in the study on morphological profiling of immunological synapses by German, Vulliard et al.
View article: GermanVulliard2020.zip
GermanVulliard2020.zip Open
This dataset contains the CellProfiler pipelines and the corresponding morphological measurements used in the study on morphological profiling of immunological synapses by German, Vulliard et al.
View article: An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH
An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH Open
An essential role for the bmp-smad pathway in hepcidin induction during ER stress and NAFLD/NASH. 7. Congress of the International Biolron Society (IBIS)
View article: Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection
Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection Open
Retention of iron in tissue macrophages via upregulation of hepcidin (HAMP) and downregulation of the iron exporter ferroportin (FPN) is thought to participate in the establishment of anemia of inflammation after infection. However,…
View article: Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice Open
Key Points Hyperactivation of the BMP-SMAD pathway blunts EPO-mediated hepcidin inhibition. Lack of BMP-SMAD pathway inhibition by matriptase-2 abrogates the ERFE-mediated hepcidin suppression in response to EPO.