Aude Sylvain
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View article: A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation Open
Summary The NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome is a cytoplasmic signaling complex that promotes inflammation in response to signals from infection and cellular damage. Incre…
View article: Supplementary Data 6 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 6 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 63K, Supplemental Data 6: Combined blocking antibodies effect on breast cancer lysis. We measured activated NK-cells mediated cytotoxicity (IL2/IL15 overnight activation), in 4-hours assays, in the presence of blocking antibodie…
View article: Supplementary Data 9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 75K, FVB control mice (n=6, light grey bars) and MMTV-Neu mice (n=6, dark grey bars) were followed from 3 months of age until tumor occurrence, and a Kaplan-Meier curve was established to determine tumor-free survival. Arrows in…
View article: Supplementary Data 3 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 3 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 47K, Breast cancer cell lines known features (Perou and Sorlie cell lines classification, ERBB2 status, estrogen and progesterone expression, Phenotype of the stem cell population, HLA-C genotype and allotype).
View article: Supplementary Data Legends 1-9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data Legends 1-9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 113K
View article: Supplementary Data 2 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 2 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 84K, List of NK-cell Receptors ligands expressed by tumor cells and associated probesets.
View article: Supplementary Methods from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Methods from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 64K, Cells isolation from peripheral blood and breast primary tumor.
View article: Supplementary Data 2 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 2 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 84K, List of NK-cell Receptors ligands expressed by tumor cells and associated probesets.
View article: Supplementary Data 5 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 5 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 131K, Phospho-Immunoreceptor arrays of NK-cells exposed to breast cancer cell lines. NK-cells (E:T 2:1) were incubated 10mn with K562 and with the respective breast tumor cells and immediately lysed. The lysate was hybridized on…
View article: Supplementary Data 7 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 7 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 66K, Comparison of breast cancer stem cell versus differentiated breast tumor cells isolation procedures. Sorted populations of breast cancer stem cells (in red) versus differentiated cancer cells (Black) with a luminal phenotyp…
View article: Supplementary Methods from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Methods from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 64K, Cells isolation from peripheral blood and breast primary tumor.
View article: Supplementary Data 9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 75K, FVB control mice (n=6, light grey bars) and MMTV-Neu mice (n=6, dark grey bars) were followed from 3 months of age until tumor occurrence, and a Kaplan-Meier curve was established to determine tumor-free survival. Arrows in…
View article: Supplementary Data 5 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 5 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 131K, Phospho-Immunoreceptor arrays of NK-cells exposed to breast cancer cell lines. NK-cells (E:T 2:1) were incubated 10mn with K562 and with the respective breast tumor cells and immediately lysed. The lysate was hybridized on…
View article: Data from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Data from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
Breast cancer is the leading cause of death for women between the ages of 35 to 65. This is mostly due to intertumor heterogeneity and the lack of specific therapies for all subtypes. However, some breast cancers with an unexpected good pr…
View article: Supplementary Data 8 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 8 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 39K, NK-cell phenotypes after exposition to breast tumor cells. NKG2D, NKp30 and DNAM-1 MFI values without, or after direct or indirect exposition to breast cancer cell lines. A paired nonparametric Wilcoxon t-test was used to e…
View article: Supplementary Data Legends 1-9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data Legends 1-9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 113K
View article: Supplementary Data 8 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 8 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 39K, NK-cell phenotypes after exposition to breast tumor cells. NKG2D, NKp30 and DNAM-1 MFI values without, or after direct or indirect exposition to breast cancer cell lines. A paired nonparametric Wilcoxon t-test was used to e…
View article: Supplementary Data 4 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 4 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 24K, Breast tumor cells killing in an autologous settings. NK-cells (after overnight incubation in IL2/IL15) were tested for direct cytotoxic activity against autologous Epcam+ tumor cells (E/T = 2:1, n = 3 donors). The percenta…
View article: Data from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Data from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
Breast cancer is the leading cause of death for women between the ages of 35 to 65. This is mostly due to intertumor heterogeneity and the lack of specific therapies for all subtypes. However, some breast cancers with an unexpected good pr…
View article: Supplementary Data 4 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 4 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 24K, Breast tumor cells killing in an autologous settings. NK-cells (after overnight incubation in IL2/IL15) were tested for direct cytotoxic activity against autologous Epcam+ tumor cells (E/T = 2:1, n = 3 donors). The percenta…
View article: Supplementary Data 1 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 1 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 320K, Supplemental Data 1: Ligands and receptors respectively expressed by tumor and NK-cells. Natural killer (NK) cells are components of the innate immune system that play a central role against tumor cells. They have an innat…
View article: Supplementary Data 1 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 1 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 320K, Supplemental Data 1: Ligands and receptors respectively expressed by tumor and NK-cells. Natural killer (NK) cells are components of the innate immune system that play a central role against tumor cells. They have an innat…
View article: Supplementary Data 6 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 6 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 63K, Supplemental Data 6: Combined blocking antibodies effect on breast cancer lysis. We measured activated NK-cells mediated cytotoxicity (IL2/IL15 overnight activation), in 4-hours assays, in the presence of blocking antibodie…
View article: Supplementary Data 3 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 3 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 47K, Breast cancer cell lines known features (Perou and Sorlie cell lines classification, ERBB2 status, estrogen and progesterone expression, Phenotype of the stem cell population, HLA-C genotype and allotype).
View article: Supplementary Data 7 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Supplementary Data 7 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition Open
PDF file - 66K, Comparison of breast cancer stem cell versus differentiated breast tumor cells isolation procedures. Sorted populations of breast cancer stem cells (in red) versus differentiated cancer cells (Black) with a luminal phenotyp…