Audi Setiadi
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View article: Morphologic and Electrophoretic Features of Hemoglobin Bart's Hydrops Fetalis
Morphologic and Electrophoretic Features of Hemoglobin Bart's Hydrops Fetalis Open
View article: The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset still’s disease, and COVID-19 cytokine storm
The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset still’s disease, and COVID-19 cytokine storm Open
View article: The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset Still’s disease, and COVID-19 cytokine storm
The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset Still’s disease, and COVID-19 cytokine storm Open
Objectives Cytokine storm syndromes such as hemophagocytic lymphohistiocytosis (HLH), Adult-onset Still’s disease (AOSD), and COVID-19 cytokine storm (CCS) are characterized by markedly elevated inflammatory cytokines. However clinical mea…
View article: <scp>CRP</scp> and <scp>sCD25</scp> help distinguish between adult‐onset Still's disease and <scp>HLH</scp>
<span>CRP</span> and <span>sCD25</span> help distinguish between adult‐onset Still's disease and <span>HLH</span> Open
Objective Adult‐onset Still's disease (AOSD) and secondary hemophagocytic lymphohistiocytosis (sHLH) are both hyperferritinemic cytokine storm syndromes that can be difficult to distinguish from each other in hospitalized patients. The obj…
View article: A sinister case of pseudothrombocytosis
A sinister case of pseudothrombocytosis Open
A newborn girl with ileal atresia presented with bilious emesis and bowel perforation. Automated blood count using an XN-9000 analyser (Sysmex, Kobe, Japan) run within 30 min of collection showed a haemoglobin of 106 g/L, white blood cell …
View article: Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma
Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma Open
Inborn errors of immunity (IEI) are a group of disorders caused by deleterious variants in immune-related genes, including some that function as epigenetic regulators. Additional sex combs-like 1 (ASXL1) is an epigenetic modifier that has …
View article: A longitudinal single-cell atlas of treatment response in pediatric AML
A longitudinal single-cell atlas of treatment response in pediatric AML Open
Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular composition, driver alterations and prognosis. Characterization of this heterogeneity and how it affects treatment response remains understudied in pediatri…
View article: Monolobated Megakaryocytes in Diamond Blackfan Anemia with RPL5 Mutation at Disease Presentation Mimicking Myelodysplastic Syndrome
Monolobated Megakaryocytes in Diamond Blackfan Anemia with RPL5 Mutation at Disease Presentation Mimicking Myelodysplastic Syndrome Open
View article: A germline heterozygous dominant negative<i>IKZF2</i>variant causing syndromic primary immune regulatory disorder and ICHAD
A germline heterozygous dominant negative<i>IKZF2</i>variant causing syndromic primary immune regulatory disorder and ICHAD Open
Monogenic defects that impair the control of inflammation and tolerance lead to profound immune dysregulation, including autoimmunity and atopy. Studying these disorders reveals important molecular and cellular factors that regulate human …
View article: PB2039: INFLAMMATORY MARKERS IN HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS - A SINGLE CENTRE STUDY
PB2039: INFLAMMATORY MARKERS IN HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS - A SINGLE CENTRE STUDY Open
Topic: 12. Bone marrow failure syndromes incl. PNH - Clinical Background: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathological immune activation that can be difficult to distinguish from other cytokine storm syndromes suc…
View article: Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases Open
View article: Supplementary Figure Legend from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas
Supplementary Figure Legend from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas Open
Supplementary Figure Legend from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas
View article: Data from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas
Data from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas Open
Expression of transporter associated with antigen processing (TAP) is often lost in metastatic carcinomas, resulting in defective antigen processing and presentation and escape of the cancer cells from immune surveillance. In this study, t…
View article: Data from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas
Data from Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas Open
Expression of transporter associated with antigen processing (TAP) is often lost in metastatic carcinomas, resulting in defective antigen processing and presentation and escape of the cancer cells from immune surveillance. In this study, t…
View article: COVID-19, haemophagocytic lymphohistiocytosis, and infection-induced cytokine storm syndromes
COVID-19, haemophagocytic lymphohistiocytosis, and infection-induced cytokine storm syndromes Open
View article: Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy
Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy Open
Discovery of humans with monogenic disorders has a rich history of generating new insights into biology. Here we report the first human identified with complete deficiency of nuclear factor of activated T cells 1 (NFAT1). NFAT1, encoded by…
View article: Targeted treatment of immune thrombocytopenia in CTLA‐4 insufficiency: a case report
Targeted treatment of immune thrombocytopenia in CTLA‐4 insufficiency: a case report Open
Immune thrombocytopenia (ITP) is characterized by thrombocytopenia (peripheral blood platelet count < 100 × 109/l) which can be primary (without underlying causes) or secondary.1 Secondary ITP can be associated with infections, drugs, lymp…
View article: EDTA-induced platelet hypogranulation: beware of dysplasia mimic!
EDTA-induced platelet hypogranulation: beware of dysplasia mimic! Open
View article: T‐lymphoblastic transformation of chronic myeloid leukemia
T‐lymphoblastic transformation of chronic myeloid leukemia Open
An 85-year-old presented with abdominal pain and WBC count of 245.9 × 109/L with 26.9% blasts (66.39 × 109/L): neutrophils 110.66 × 109/L, eosinophils 12.30 × 109/L, basophils 0.0 × 109/L, metamyelocytes 7.38 × 109/L, myelocytes 17.22 × 10…
View article: Clinical and laboratory features associated with myeloperoxidase expression in pediatric B‐lymphoblastic leukemia
Clinical and laboratory features associated with myeloperoxidase expression in pediatric B‐lymphoblastic leukemia Open
Background B‐lymphoblastic leukemia (B‐ALL) is the most common childhood malignancy, and its diagnosis requires immunophenotypically demonstrating blast B cell lineage differentiation. Expression of myeloperoxidase (MPO) in B‐ALL is well‐d…
View article: CD138-negative plasma cell myeloma: a diagnostic challenge and a unique entity
CD138-negative plasma cell myeloma: a diagnostic challenge and a unique entity Open
Plasma cell neoplasms may exhibit variations in morphology and immunophenotype, which can mimic mature B-cell lymphoproliferative disorders and pose diagnostic challenges. This case illustrates a rare entity of plasma cell myeloma, where t…