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View article: Seroprevalence and renal carriage of pathogenic <i>Leptospira</i> in livestock in Cotonou, Benin
Seroprevalence and renal carriage of pathogenic <i>Leptospira</i> in livestock in Cotonou, Benin Open
Background Leptospirosis is a zoonotic disease. It is particularly prevalent in tropical countries and has major consequences for human and animal health. In Benin, the disease's epidemiology remains poorly understood, especially in livest…
Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1 Open
Epistasis affects genome evolution together with our ability to predict individual mutation effects. The mechanistic basis of epistasis remains, however, largely unknown. To quantify and better understand interactions between fitness-affec…
Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1 Open
Epistasis affects genome evolution together with our ability to predict individual mutation effects. The mechanistic basis of epistasis remains, however, largely unknown. To quantify and better understand interactions between fitness-affec…
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway Open
Complex fitness interactions between alleles and expression-modulating environment are explained by a simple metabolic model.
Flux, toxicity and protein expression costs shape genetic interaction in a metabolic pathway Open
Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by the dependence of their effects on the genetic background and environment. Even when molecular interactions between gen…