Explanipedia

Validation of a new non-invasive predictive score (KASAI) for primary aldosteronism subtyping Open

Guillaume Pierman, Karin Zibar, Darko Kaštelan, Carlien De Herdt, Natacha Driessens , et al. · 2025

Introduction Adrenal venous sampling (AVS) is considered the gold standard test for primary aldosteronism (PA) subtyping. Considering the limited availability of this challenging procedure, we propose a noninvasive score predicting unilate…

Non‐Cirrhotic Steatotic Liver Disease is Associated With Impaired Muscle Function: A Cross‐Sectional Study Open

Guillaume Hénin, Alexis Goffaux, Salomé Declerck, Stéphanie André‐Dumont, Étienne Pendeville , et al. · 2025

Background Impaired muscle function is frequent in cirrhosis and potentially participates in liver disease progression. Data from non‐cirrhotic patients with steatotic liver disease (SLD) are lacking. Our aims were to determine if muscle f…

Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction‐associated steatotic liver disease? Open

Guillaume Hénin, Audrey Loumaye, Louise Deldicque, Isabelle Leclercq, Nicolas Lanthier · 2024

Myosteatosis is highly prevalent in metabolic dysfunction‐associated steatotic liver disease (MASLD) and could reciprocally impact liver function. Decreasing muscle fat could be indirectly hepatoprotective in MASLD. We conducted a review t…

Administration of adiponectin receptor agonist AdipoRon relieves cancer cachexia by mitigating inflammation in tumour‐bearing mice Open

Isabelle S. Massart, A F Kouakou, Nathan Pelet, Pascale Lause, Olivier Schakman , et al. · 2024

Background Cancer cachexia is a life‐threatening, inflammation‐driven wasting syndrome that remains untreatable. Adiponectin, the most abundant adipokine, plays an important role in several metabolic processes as well as in inflammation mo…

Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis Open

Camille Lefevre, Morgane M. Thibaut, Audrey Loumaye, Jean‐Paul Thissen, Audrey M. Neyrinck , et al. · 2024

Administration of adiponectin receptor agonist adiporon relieves cancer cachexia-induced muscle wasting by mitigating inflammation in tumor bearing mice Open

Isabelle S. Massart, N. Kouakou, Pascale Lause, Olivier Schakman, Audrey Loumaye , et al. · 2023

Is myostatin a biomarker of skeletal muscle mass ? Open

Laura Orioli, Susan Samaras, Kiswendsida Sawadogo, Pascale Lause, Marie de Barsy , et al. · 2023

Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease Open

Guillaume Hénin, Audrey Loumaye, Isabelle Leclercq, Nicolas Lanthier · 2023

SAT670 Is Myostatin A Biomarker Of Skeletal Muscle Mass? Open

Laura Orioli, Sofia Samaras, Pascale Lause, Marie de Barsy, Jean-Paul Thissen , et al. · 2023

Disclosure: L. Orioli: None. S. Samaras: None. P. Lause: None. M. de Barsy: None. J.M. Thissen: None. A. Loumaye: None. Rationale: Our study aims to determine whether myostatin is a biomarker of muscle mass in cancer cachexia and obesity. …

Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery Open

Laura Orioli, Mickaël Canouil, Kiswendsida Sawadogo, Lijiao Ning, Louise Deldicque , et al. · 2023

Importance and Objective The identification of myokines susceptible to improve glucose homeostasis following bariatric surgery could lead to new therapeutic approaches for type 2 diabetes. Methods Changes in the homeostasis model assessmen…

A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients Open

Quentin Binet, Audrey Loumaye, Michel P. Hermans, Nicolas Lanthier · 2023

Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity, with high adherence of high-risk patients to subsequent noninvasive exams.

EDA2R–NIK signalling promotes muscle atrophy linked to cancer cachexia Open

Şevval Nur Bilgiç, Aylin Domaniku, Batu Toledo, Samet Agca, Bahar Zehra Camurdanoglu Weber , et al. · 2023

EDA2R/NIK signaling promotes skeletal muscle atrophy linked to cancer cachexia Open

Şevval Nur Bilgiç, Aylin Domaniku, Batu Toledo, Samet Agca, Bahar Zehra Camurdanoglu Weber , et al. · 2023

Summary Skeletal muscle atrophy is a hallmark of the cachexia syndrome that is associated with poor survival and reduced quality of life in cancer patients 1 . Muscle atrophy involves excessive protein catabolism and loss of muscle mass an…

Non-invasive screening, staging and management of metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus patients : what do we know so far ? Open

Quentin Binet, Audrey Loumaye, Vanessa Preumont, J-P Thissen, Michel P. Hermans , et al. · 2022

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the evidence of steatosis in the setting of a metabolic risk condition such as type 2 diabetes mellitus (T2DM). Indeed, T2DM and liver steatosis share common pathophysiologica…

Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis Open

Audrey Loumaye, Pascale Lause, Xiaoling Zhong, Teresa A. Zimmers, Laure B. Bindels , et al. · 2022

Activin A (ActA) is considered to play a major role in cancer-induced cachexia (CC). Indeed, circulating ActA levels are elevated and predict survival in patients with CC. However, the mechanisms by which ActA mediates CC development and i…

p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition Open

Caroline Barbé, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean‐Paul Thissen · 2021

Skeletal muscle, the most abundant tissue in the body, plays vital roles in locomotion and metabolism. Understanding the cellular processes that govern regulation of muscle mass and function represents an essential step in the development …

<i>Dysosmobacter welbionis</i> is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice Open

Tiphaine Le Roy, Emilie Moens de Hase, Matthias Van Hul, Adrien Paquot, Rudy Pelicaen , et al. · 2021

Objective To investigate the abundance and the prevalence of Dysosmobacter welbionis J115 T , a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study…

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists Open

Clara Depommier, Rosa Maria Vitale, Fabio Arturo Iannotti, Cristoforo Silvestri, Nicolas Flamand , et al. · 2021

Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the c…

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models Open

Clara Depommier, Nicolas Flamand, Rudy Pelicaen, Dominique Maiter, Jean‐Paul Thissen , et al. · 2021

The global obesity epidemic continues to rise worldwide. In this context, unraveling new interconnections between biological systems involved in obesity etiology is highly relevant. Dysregulation of the endocannabinoidome (eCBome) is assoc…

Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome Open

Clara Depommier, Amandine Everard, Céline Druart, Dominique Maiter, Jean‐Paul Thissen , et al. · 2021

Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at i…

Inflammation‐induced cholestasis in cancer cachexia Open

Morgane M. Thibaut, Martina Sboarina, Martin Roumain, Sarah A. Pötgens, Audrey M. Neyrinck , et al. · 2020

Background Cancer cachexia is a debilitating metabolic syndrome contributing to cancer death. Organs other than the muscle may contribute to the pathogenesis of cancer cachexia. This work explores new mechanisms underlying hepatic alterati…

Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Open

Isabelle S. Massart, Geneviève Paulissen, Audrey Loumaye, Pascale Lause, Sarah A. Pötgens , et al. · 2020

Loss of skeletal muscle mass in cancer cachexia is recognized as a predictor of mortality. This study aimed to characterize the changes in the muscle secretome associated with cancer cachexia to gain a better understanding of the mechanism…

Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial Open

Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle , et al. · 2020

Food4Gut multicenter randomized placebo-controlled trial. v1 Open

Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle , et al. · 2019

Objectives:We describe the methodology of a trial designed to highlight the interest of vegetables rich in ITF-prebiotics in obese adults. DESIGN:150 obese subjects (BMI> 30 kg.m-2; 18–65 years) recruited in three different university hosp…

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Open

Clara Depommier, Amandine Everard, Céline Druart, Hubert Plovier, Matthias Van Hul , et al. · 2019

Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia Open

Parash Parajuli, Santosh Kumar, Audrey Loumaye, Purba Singh, Sailaja Eragamreddy , et al. · 2018

Increased gut permeability in cancer cachexia: mechanisms and clinical relevance Open

Laure B. Bindels, Audrey M. Neyrinck, Audrey Loumaye, Émilie Catry, Hannah Walgrave , et al. · 2018

Intestinal disorders often occur in cancer patients, in association with body weight loss, and this alteration is commonly attributed to the chemotherapy. Here, using a mouse model of cancer cachexia induced by ectopic transplantation of C…

Biomarkers of cancer cachexia Open

Audrey Loumaye, Jean‐Paul Thissen · 2017

Circulating <span>Activin A</span> predicts survival in cancer patients Open

Audrey Loumaye, Marie de Barsy, Maxime Nachit, Pascale Lause, Aline van Maanen , et al. · 2017

Background Several experimental evidences pinpoint the possible role of Activin A (ActA) as a driver of cancer cachexia. Supporting this hypothesis, we showed recently that human cancer cachexia is associated with high ActA levels. Moreove…

Abdominal Fat and Muscle Measurement on Routine CT: Is It Useful? Open

Maxime Nachit, Pierre Tréfois, Audrey Loumaye, Jean‐Paul Thissen, Étienne Danse · 2016

Defining body composition has always been challenging and a wide range of methods have been developed. Amongthem, computed tomography (CT) is on the rise as a strong correlation exists between tissues at abdominal levels and the whole body…

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