Mathieu Mateo
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View article: Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein Open
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins. All Mammarenavirus identified to date share a comm…
View article: SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation
SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation Open
Sterile alpha motif domain-containing proteins 9 and 9-like (SAMD9/9L) are associated with life-threatening genetic diseases in humans and are restriction factors of poxviruses. Yet, their cellular function and the extent of their antivira…
View article: Stable structures or PABP1 loading protects cellular and viral RNAs against ISG20-mediated decay
Stable structures or PABP1 loading protects cellular and viral RNAs against ISG20-mediated decay Open
ISG20 is an IFN-induced 3′–5′ RNA exonuclease that acts as a broad antiviral factor. At present, the features that expose RNA to ISG20 remain unclear, although recent studies have pointed to the modulatory role of epitranscriptomic modific…
View article: Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model
Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model Open
Viral hemorrhagic fevers (HF) are a group of acute febrile diseases with high mortality rates. Although hemostatic dysfunction appears to be a major determinant of the severity of the disease, it is still unclear what pathogenic mechanisms…
View article: Stable Structures or poly(A)-binding protein loading protect cellular and viral RNAs against ISG20-mediated decay
Stable Structures or poly(A)-binding protein loading protect cellular and viral RNAs against ISG20-mediated decay Open
ISG20 is an interferon-induced 3’-to-5’ RNA exonuclease that acts as a broad antiviral factor. At present, the features that expose RNA to ISG20 remain unclear, although recent studies have pointed to the modulatory role of epitranscriptom…
View article: The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC
The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC Open
Sterile alpha motif domain-containing proteins 9 and 9L (SAMD9/9L) are associated with life-threatening genetic diseases and are restriction factors of poxviruses. Yet, their cellular function and the extent of their antiviral role are poo…
View article: Rapid protection induced by a single-shot Lassa vaccine in cynomolgus monkeys (transcriptomic dataset)
Rapid protection induced by a single-shot Lassa vaccine in cynomolgus monkeys (transcriptomic dataset) Open
Lassa fever outbreaks hit West African countries every year and there is still no licensed vaccine to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a single-shot vaccine that induces protective immunity …
View article: Rapid protection induced by a single-shot Lassa vaccine in cynomolgus monkeys (transcriptomic dataset)
Rapid protection induced by a single-shot Lassa vaccine in cynomolgus monkeys (transcriptomic dataset) Open
Lassa fever outbreaks hit West African countries every year and there is still no licensed vaccine to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a single-shot vaccine that induces protective immunity …
View article: A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates
A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates Open
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVA…
View article: Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys
Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys Open
The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two out…
View article: Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys
Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys Open
The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two out…
View article: A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains
A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains Open
A single-dose vaccine confers cross-protection and long-term efficacy against Lassa virus in cynomolgus monkeys.
View article: Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques
Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques Open
Lassa virus (LASV) is endemic in West Africa and induces a viral hemorrhagic fever (VHF) with up to 30% lethality among clinical cases. The mechanisms involved in control of Lassa fever or, in contrast, the ensuing catastrophic illness and…
View article: Rational design of universal immunotherapy for TfR1-tropic arenaviruses
Rational design of universal immunotherapy for TfR1-tropic arenaviruses Open
Certain arenaviruses that circulate in rodent populations can cause life-threatening hemorrhagic fevers when they infect humans. Due to their efficient transmission, arenaviruses pose a severe risk for outbreaks and might be exploited as b…
View article: E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles
E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles Open
Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related, rodent-born mammarenaviruses. LASV is the causative agent of Lassa fever, a deadly hemorrhagic fever endemic in West Africa, whereas MOPV is non-pathogenic in humans. The …
View article: A 40 months follow-up of Ebola virus disease survivors in Guinea (Postebogui) reveals longterm detection of Ebola viral RNA in semen and breast milk
A 40 months follow-up of Ebola virus disease survivors in Guinea (Postebogui) reveals longterm detection of Ebola viral RNA in semen and breast milk Open
Background With the increasing frequency and impact of Ebola virus disease (EVD) outbreaks illustrated by recent epidemics, good knowledge on extent of viral persistance or RNA detection in body fluids from survivors is urgently needed. Me…
View article: Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015
Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015 Open
Lassa fever has not been reported in Côte d'Ivoire. We performed a retrospective analysis of human serum samples collected in Côte d'Ivoire in the dry seasons (January-April) during 2015-2018. We identified a fatal human case of Lassa feve…
View article: <i>Trans</i>-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells
<i>Trans</i>-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells Open
Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a trans-endocytosis process. We find that internalized nectin-1–nectin-4 complexes follo…
View article: One-shot immunization using a Measles/Lassa vaccine fully protects cynomolgus monkeys against Lassa fever
One-shot immunization using a Measles/Lassa vaccine fully protects cynomolgus monkeys against Lassa fever Open
Purpose: Lassa fever is a major public health issue in Western Africa and there is still no licensed vaccine. Here we have used the Measles virus (MeV) vaccine platform to generate Lassa fever vaccine candidates expressing the Lassa virus …
View article: Immune parameters and outcomes during Ebola virus disease
Immune parameters and outcomes during Ebola virus disease Open
French Ministry of Foreign Affairs, the Agence Française de Développement, and the Institut Pasteur.
View article: Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells
Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells Open
Lassa virus (LASV) is responsible for a viral hemorrhagic fever in humans and the death of 3,000 to 5,000 people every year. The immune response to LASV is poorly understood, but type I interferon (IFN-I) and T-cell responses appear to be …
View article: A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins
A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins Open
Several Old World and New World arenaviruses are responsible for severe endemic and epidemic hemorrhagic fevers, whereas other members of the Arenaviridae family are nonpathogenic. To date, no approved vaccines, antivirals, or specific tre…
View article: Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea
Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea Open
BACKGROUND. The pathogenesis of Ebola virus (EBOV) disease (EVD) is poorly characterized. The establishment of well-equipped diagnostic laboratories close to Ebola treatment centers (ETCs) has made it possible to obtain relevant virologica…
View article: Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells
Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells Open
Measles is a highly contagious, acute viral illness. Immune cells within the airways are likely first targets of infection, and these cells traffic measles virus (MeV) to lymph nodes for amplification and subsequent systemic dissemination.…
View article: The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia
The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia Open
The discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial receptor provides a new vantage point from which to characterize its rapid spread in the airway epithelium. We show here that in well-diffe…
View article: Connections matter − how viruses use cell–cell adhesion components
Connections matter − how viruses use cell–cell adhesion components Open
The epithelium is a highly organized type of animal tissue. Except for blood and lymph vessels, epithelial cells cover the body, line its cavities in single or stratified layers and support exchange between compartments. In addition, epith…