Audrey R. Odom John
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View article: Machine learning enables de novo multiepitope design of <i>Plasmodium falciparum</i> circumsporozoite protein to target trimeric L9 antibody
Machine learning enables de novo multiepitope design of <i>Plasmodium falciparum</i> circumsporozoite protein to target trimeric L9 antibody Open
Currently approved vaccines for the prevention of malaria provide only partial protection against disease due to high variability in the quality of induced antibodies. These vaccines present the unstructured central repeat region, as well …
View article: Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling
Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling Open
Chronic wasting disease (CWD) is a universally fatal, transmissible prion disease affecting cervids. Primarily found among deer populations in North America, the disease has spread across the continent and made forays into Europe and Asia …
View article: Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites
Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites Open
Plasmodium falciparum, the parasite responsible for nearly all cases of severe malaria, must survive challenging environments to persist in its human host. Symptomatic malaria is characterized by periodic fevers corresponding to the 48-hou…
View article: Pocapavir for neonatal enteroviral sepsis: limitations of rapid viral sequencing on treatment decisions
Pocapavir for neonatal enteroviral sepsis: limitations of rapid viral sequencing on treatment decisions Open
Background Neonatal enterovirus infection can be severe and life-threatening, and there is ongoing interest in the development of antiviral compounds; however, their clinical efficacy has not been definitively proven. Case Summary We descr…
View article: Machine learning enables <i>de novo</i> multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody
Machine learning enables <i>de novo</i> multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody Open
Currently approved vaccines for the prevention of malaria provide only partial protection against disease, due to high variability in the quality of induced antibodies. These vaccines present the unstructured central repeat region, as well…
View article: Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin
Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin Open
View article: 457 | BREATH BIOMARKERS FOR PREDICTION OF CYTOKINE RELEASE SYNDROME IN PATIENTS RECEIVING CHIMERIC ANTIGEN RECEPTOR T‐CELL THERAPY
457 | BREATH BIOMARKERS FOR PREDICTION OF CYTOKINE RELEASE SYNDROME IN PATIENTS RECEIVING CHIMERIC ANTIGEN RECEPTOR T‐CELL THERAPY Open
View article: Upper and lower airway microbiota across infancy and childhood
Upper and lower airway microbiota across infancy and childhood Open
Background The upper and lower respiratory tracts feature distinct environments and responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify relationships b…
View article: Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)
Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) Open
The continued emergence of antimalarial drug resistance highlights the need to develop new antimalarial therapies. Unfortunately, new drug development is often hampered by undesirable drug-like properties of lead compounds. Prodrug approac…
View article: Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling
Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling Open
Chronic Wasting Disease (CWD) is a universally fatal, transmissible prion disease affecting cervids. Primarily found among deer populations in North America, the disease has spread across the continent and made forays into Europe and Asia …
View article: Differential Severity of Sars-Cov-2 Variant Infections in Children and Adults with Covid-19
Differential Severity of Sars-Cov-2 Variant Infections in Children and Adults with Covid-19 Open
View article: Essential role for HSP40 in asexual replication and thermotolerance of malaria parasites
Essential role for HSP40 in asexual replication and thermotolerance of malaria parasites Open
Plasmodium falciparum, the parasite responsible for nearly all cases of severe malaria, must survive challenging environments to persist in its human host. Symptomatic malaria is characterized by periodic fevers corresponding to the 48-hou…
View article: Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<scp>d</scp>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<span>d</span>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity Open
The methyl-d-erythritol phosphate (MEP) pathway has emerged as an interesting target in the fight against antimicrobial resistance. The pathway is essential in many human pathogens, including Plasmodium falciparum (Pf), but i…
View article: Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)
Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) Open
The continued emergence of antimalarial drug resistance highlights the need to develop new antimalarial therapies. Unfortunately, new drug development is often hampered by poor drug-like properties of lead compounds. Prodrugging temporaril…
View article: Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States
Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States Open
Post-artesunate delayed hemolysis (PADH) occurred in 6 of 24 children treated with artesunate for severe malaria in the United States; however, severe hemolysis requiring hospitalization or transfusion was rare. In children in the United S…
View article: The breath volatilome is shaped by the gut microbiota
The breath volatilome is shaped by the gut microbiota Open
The gut microbiota is widely implicated in host health and disease, inspiring translational efforts to implement our growing body of knowledge in clinical settings. However, the need to characterize gut microbiota by its genomic content li…
View article: Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata
Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata Open
Background Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults. Methods This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVI…
View article: Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy
Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy Open
Background Many insect-borne pathogens appear to manipulate the odors of their hosts in ways that influence vector behaviors. In our prior work, we identified characteristic changes in volatile emissions of cultured Plasmodium falciparum p…
View article: Oops, the Microbes Did It Again: Gut Dysbiosis Precedes Late-Onset Meningitis
Oops, the Microbes Did It Again: Gut Dysbiosis Precedes Late-Onset Meningitis Open
Over the last two decades, the study of the microbiome has vastly expanded.What was once an underappreciated contributor to human health-outside of consideration as a source of pathogens and contamination-is now understood as an "organ" in…
View article: High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i> Open
In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing, and compounds with d…
View article: Metabolomic and Immunologic Discriminators of MIS-C at Emergency Room Presentation
Metabolomic and Immunologic Discriminators of MIS-C at Emergency Room Presentation Open
Multisystem Inflammatory Syndrome in Childhood (MIS-C) follows SARS-CoV-2 infection and frequently leads to intensive care unit admission. The inability to rapidly discriminate MIS-C from similar febrile illnesses delays treatment and lead…
View article: Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs
Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs Open
Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis , and act on-target intracellularly.
View article: Within-host influenza viral diversity in the pediatric population as a function of age, vaccine, and health status
Within-host influenza viral diversity in the pediatric population as a function of age, vaccine, and health status Open
Seasonal influenza virus predominantly evolves through antigenic drift, marked by the accumulation of mutations at antigenic sites. Because of antigenic drift, influenza vaccines are frequently updated, though their efficacy may still be l…
View article: 763. Infection Prevention Resource Physicians to Build On-Call Capacity
763. Infection Prevention Resource Physicians to Build On-Call Capacity Open
Background The COVID-19 pandemic showed that infection prevention and control (IPC) human resources are critical and are stretched in prolonged crisis. There has also been a shift from experienced infection preventionists (IPs) during the …
View article: HAD2 Regulates Central Carbon Metabolism in Malaria Parasite <i>P. falciparum</i>
HAD2 Regulates Central Carbon Metabolism in Malaria Parasite <i>P. falciparum</i> Open
Background The malaria parasite Plasmodium falciparum causes nearly half a million deaths each year. Widespread resistance to antimalarials prompts an urgent need for novel drug targets both unique and essential to the parasite. The methyl…
View article: Determination of Seasonal Influenza Intrahost Viral Diversity as a Function of Host Immune Status
Determination of Seasonal Influenza Intrahost Viral Diversity as a Function of Host Immune Status Open
Background Seasonal influenza viruses evolve predominately via antigenic drift, the slow accumulations of genetic mutations leading to changes in key antigenic sites. Due to the accumulation of antigenic changes, influenza vaccines must be…
View article: Volatile profiling distinguishes <i>Streptococcus pyogenes</i> from other respiratory streptococcal species
Volatile profiling distinguishes <i>Streptococcus pyogenes</i> from other respiratory streptococcal species Open
Sore throat is one of the most common complaints encountered in the ambulatory clinical setting. Rapid, culture-independent diagnostic techniques that do not rely on pharyngeal swabs would be highly valuable as a point-of-care strategy to …
View article: Thinking Small, Stinking Big: The World of Microbial Odors
Thinking Small, Stinking Big: The World of Microbial Odors Open
Humans live embedded in an ecosystem of microbial life.Nowhere is this ecosystem more apparent to the naked eye (or, rather, nose) than in the world of microbially derived odors.From the fungal fragrances that sing of environmental mold to…
View article: Developmental progression of the nasopharyngeal microbiome during childhood and association with the lower airway microbiome
Developmental progression of the nasopharyngeal microbiome during childhood and association with the lower airway microbiome Open
Background The upper (URT) and lower (LRT) respiratory tract feature distinct environments and responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify rela…
View article: MEPicides: α,β-unsaturated Fosmidomycin <i>N</i>-Acyl Analogs as Efficient Inhibitors of <i>Plasmodium falciparum</i> 1-Deoxy-<scp>d</scp>-xylulose-5-phosphate reductoisomerase
MEPicides: α,β-unsaturated Fosmidomycin <i>N</i>-Acyl Analogs as Efficient Inhibitors of <i>Plasmodium falciparum</i> 1-Deoxy-<span>d</span>-xylulose-5-phosphate reductoisomerase Open
Malaria, a mosquito-borne disease caused by several parasites of the Plasmodium genus, remains a huge threat to global public health. There are an estimated 0.5 million malaria deaths each year, mostly among African children. Unlike…