Explanipedia

Recurrent Deeply Invasive Basal Cell Carcinoma Open

Greta Milvydaitė, Audrius Ivanauskas, Tadas Keizeris, Silvija Ryškienė, Jan Pavel Rokicki , et al. · 2023

Introduction: Basal cell carcinoma (BCC) is the most frequent skin malignancy worldwide. The majority of BCCs grow slowly and have a low metastatic potential. However, they can be destructive to surrounding tissues since they are locally i…

Psychosocial assessment of male patients with persistent idiopathic facial pain—a pilot study Open

Audrius Ivanauskas, Jan Pavel Rokicki, Greta Šakalienė, Vesta Guzevičienė, Gintaras Janužis , et al. · 2023

Studies have shown that up to 70% of patients with depressive and anxiety disorders may also experience chronic pain. This study aimed to examine the correlation between depression, anxiety symptoms, sleep quality and personality traits in…

Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk Open

Ye Lu, Manuel Gentiluomo, Angelica Macauda, Domenica Gioffreda, Maria Gazouli , et al. · 2021

Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. A recessiv…

Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk Open

Ye Lu, Chiara Corradi, Manuel Gentiluomo, Evangelina López de Maturana, George Theodoropoulos , et al. · 2021

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We ai…

Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma Open

Laura Pistoni, Manuel Gentiluomo, Ye Lu, Evangelina López de Maturana, Viktor Hlaváč , et al. · 2021

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early m…

The Role of Facial Expression Analysis and Electrodermal Activity as an Objective Evaluation of Persistent Idiopathic Facial Pain Open

Jan Pavel Rokicki, Audrius Ivanauskas, Gintaras Janužis · 2021

Persistent idiopathic facial pain (PIFP) is an enigmatic condition presenting with variable features. Psychiatric comorbidities are speculated to influence PIFP. In this study, the authors evaluated patients with PIFP through the hospital …

Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility Open

Chiara Corradi, Manuel Gentiluomo, László Gajdán, Giulia Martina Cavestro, Edita Kreivėnaitė , et al. · 2021

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer‐related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation o…

Laparoscopic versus open surgery for gastric cancer: the experience of one European centre Open

Mindaugas Kiudelis, Aistė Rikterė, Kristina Žvinienė, Antanas Mickevičius, Almantas Maleckas , et al. · 2021

Gastric cancer is the third leading cause of cancer death and the fifth most common cancer worldwide: more than a million new cases of gastric cancer are diagnosed every year, with more than 700,000 deaths each year [1, 2]. It causes 1 out…

Associations between pancreatic expression quantitative trait loci (eQTLs) and pancreatic ductal adenocarcinoma risk. Open

Manuel Gentiluomo, Laura Pistoni, Giulia Peduzzi, Y. Lu, Angelica Macauda , et al. · 2020

Polymorphic variants within non-coding RNA and risk of pancreatic ductal adenocarcinoma Open

Manuel Gentiluomo, Chiara Corradi, Ye Lu, Matteo Giaccherini, Péter Hegyi , et al. · 2020

Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction Open

Alice Alessandra Galeotti, Manuel Gentiluomo, Cosmeri Rizzato, Ofure Obazee, John P. Neoptolemos , et al. · 2020

Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of d…

Genome‐wide association study identifies an early onset pancreatic cancer risk locus Open

Daniele Campa, Manuel Gentiluomo, Ofure Obazee, Alba Ballerini, Ľudmila Vodičková , et al. · 2020

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome‐wide association study (GWAS) to identify novel genetic…

Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma Open

Ofure Obazee, Lívia Archibugi, Angelo Andriulli, Pavel Souček, Ewa Małecka‐Panas , et al. · 2019

Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in impo…

Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk Open

Daniele Campa, Manuela Pastore, Manuel Gentiluomo, Renata Talar‐Wojnarowska, Juozas Kupčinskas , et al. · 2016

The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing…

First experience of salvage HDR brachytherapy after prostate cancer radiotherapy Open

Juras Kišonas, Arvydas Burneckis, Audrius Ivanauskas, R. Mickevičius, A. Vėželis · 2015

Introduction. Prostate cancer (PC) is the most common oncologic disease among men. The number of patients with recurrent PC after primary radiotherapy is increasing, unfortunately, criteria for the choice among different treatment methods …

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