August B. Smit
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View article: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease Open
Patients with Alzheimer’s disease (AD) initially show temporally-graded retrograde amnesia, which gradually progresses into more severe retrograde amnesia. Although mouse models of AD have provided insight into neurobiological mechanisms c…
View article: Author response: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
Author response: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease Open
View article: Correction: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Correction: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome Open
View article: A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain
A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain Open
View article: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome Open
View article: One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation
One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation Open
Human induced pluripotent stem cells (iPSCs) present a powerful approach to study human brain physiology and disease, yet robust, pure GABAergic induction has remained difficult. Here we present improved, single-step, transposon-based GABA…
View article: Threat intensity shapes cortical engram architecture supporting remote memory retrieval
Threat intensity shapes cortical engram architecture supporting remote memory retrieval Open
The strength of persistent threat memories depends on the intensity of an aversive experience. We combined engram tagging with chemogenetics, electrophysiology and structural spine analyses to identify how threat intensity, following mild …
View article: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease Open
Patients with Alzheimer’s disease (AD) initially show temporally graded retrograde amnesia, which gradually progresses into more severe retrograde amnesia. Although mouse models of AD have provided insight into neurobiological mechanisms c…
View article: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease Open
Patients with Alzheimer’s disease (AD) initially show temporally-graded retrograde amnesia, which gradually progresses into more severe retrograde amnesia. Although mouse models of AD have provided insight into neurobiological mechanisms c…
View article: A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain Samples
A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain Samples Open
Recent advancements in neuroproteomics have enabled detailed analysis of protein expression and function in the human brain. Post-mortem human brain studies have significantly advanced our understanding of the relationship between genetics…
View article: RIM and MUNC13 membrane–binding domains are essential for neuropeptide secretion
RIM and MUNC13 membrane–binding domains are essential for neuropeptide secretion Open
Neurons release neurotransmitters from synaptic vesicles (SVs) and neuropeptides from dense-core vesicles (DCVs). The presynaptic proteins RIM and MUNC13 play key roles in both pathways. It remains unclear how DCVs are targeted to release …
View article: A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia
A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia Open
Summary Schizophrenia (SCZ) is a complex psychiatric disorder with a diverse genetic landscape, involving common regulatory variants, rare protein-coding mutations, structural genomic rearrangements, and transcriptional dysregulation. A cr…
View article: Intergenerational transmission of complex traits and the offspring methylome
Intergenerational transmission of complex traits and the offspring methylome Open
View article: Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
View article: Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes
Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes Open
Glycine receptors (GlyRs) are typically known for mediating inhibitory synaptic transmission within the spinal cord and brainstem, but they also have key roles in embryonic brain development, learning/memory, inflammatory pain sensitizatio…
View article: Astrocyte-Synapse Structural Plasticity in Neurodegenerative and Neuropsychiatric Diseases
Astrocyte-Synapse Structural Plasticity in Neurodegenerative and Neuropsychiatric Diseases Open
Synaptic dysfunction is a common feature across a broad spectrum of brain diseases, spanning from psychopathologies such as posttraumatic stress disorder and substance use disorders to neurodegenerative diseases such as Alzheimer's disease…
View article: SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment
SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment Open
View article: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease Open
Patients with Alzheimer’s disease (AD) initially show temporally-graded retrograde amnesia, which gradually progresses into more severe retrograde amnesia. Although mouse models of AD have provided insight into neurobiological mechanisms c…
View article: Immune-Developmental Processes Contribute to Schizophrenia Risk: Insights From a Genetic Overlap Study With Height
Immune-Developmental Processes Contribute to Schizophrenia Risk: Insights From a Genetic Overlap Study With Height Open
View article: Synaptic protein CSF levels relate to memory scores in individuals without dementia
Synaptic protein CSF levels relate to memory scores in individuals without dementia Open
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression Open
Background Axon regeneration after injury to the central nervous system (CNS) is limited by an inhibitory environment but also because injured neurons fail to initiate expression of regeneration associated genes (RAGs). The potential of st…
View article: Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells
Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells Open
Learning enhances hippocampal engram cell synaptic connectivity which is crucial for engram reactivation and recall to natural cues. Memory retrieval engages only a subset of the learning-activated ensemble, indicating potential difference…
View article: Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors
Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors Open
The detrimental effects of oligomeric amyloid-β (Aβ) on synapses are considered the leading cause for cognitive deficits in Alzheimer's disease. However, through which mechanism Aβ oligomers impair synaptic structure and function remains u…
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
View article: How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms
How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms Open
View article: Continuous locomotor activity monitoring to assess animal welfare following intracranial surgery in mice
Continuous locomotor activity monitoring to assess animal welfare following intracranial surgery in mice Open
Locomotor activity can serve as a readout to identify discomfort and pain. Therefore, monitoring locomotor activity following interventions that induce potential discomfort may serve as a reliable method for evaluating animal health, compl…
View article: Synaptic protein CSF levels relate to memory scores in individuals without dementia
Synaptic protein CSF levels relate to memory scores in individuals without dementia Open
View article: Activation of G<sub>s</sub>Signaling in Cortical Astrocytes Does Not Influence Formation of a Persistent Contextual Memory Engram
Activation of G<sub>s</sub>Signaling in Cortical Astrocytes Does Not Influence Formation of a Persistent Contextual Memory Engram Open
Formation and retrieval of remote contextual memory depends on cortical engram neurons that are defined during learning. Manipulation of astrocytic G q and G i associated G-protein coupled receptor (GPCR) signaling has been shown to affect…