Augusta De Santis
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View article: Order vs. Disorder: Cholesterol and Omega-3 Phospholipids Determine Biomembrane Organization
Order vs. Disorder: Cholesterol and Omega-3 Phospholipids Determine Biomembrane Organization Open
Lipid structural diversity strongly affects biomembrane chemico-physical and structural properties in addition to membrane-associated events. At high concentrations, cholesterol increases membrane order and rigidity, while polyunsaturated …
View article: Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation
Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation Open
Gp36 is the virus envelope glycoproteins catalyzing the fusion of the feline immunodeficiency virus with the host cells. The peptide C8 is a tryptophan-rich peptide corresponding to the fragment 770W-I777 of gp36 exerting antiviral activit…
View article: Interaction with Human Serum Proteins Reveals Biocompatibility of Phosphocholine-Functionalized SPIONs and Formation of Albumin-Decorated Nanoparticles
Interaction with Human Serum Proteins Reveals Biocompatibility of Phosphocholine-Functionalized SPIONs and Formation of Albumin-Decorated Nanoparticles Open
Nanoparticles (NPs) are increasingly exploited as diagnostic and therapeutic devices in medicine. Among them, superparamagnetic nanoparticles (SPIONs) represent very promising tools for magnetic resonance imaging, local heaters for hyperth…
View article: Omega-3 polyunsaturated fatty acids do not fluidify bilayers in the liquid-crystalline state
Omega-3 polyunsaturated fatty acids do not fluidify bilayers in the liquid-crystalline state Open
This work reports on the effects of two omega-3 fatty acids, namely docosahexaenoic (C22:6 4,7,10,13,16,19 ) acid (DHA), and eicosapentaenoic (C20:5 5,8,11,14,17 ) acid (EPA), with oleic (C18:1 9 ) acid (OA) as a control, on the gel-liquid…
View article: Preferential interaction of the Alzheimer peptide Aβ‐(1–42) with Omega‐3‐containing lipid bilayers: structure and interaction studies
Preferential interaction of the Alzheimer peptide Aβ‐(1–42) with Omega‐3‐containing lipid bilayers: structure and interaction studies Open
Many age‐related neurodegenerative diseases, including Alzheimer Disease ( AD ), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega‐3 phospholipids seems to reduce the AD incidence. To investiga…