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View article: Real world outcomes of faricimab in treatment resistant neovascular age-related macular degeneration among Asian patients
Real world outcomes of faricimab in treatment resistant neovascular age-related macular degeneration among Asian patients Open
To describe the real-world efficacy and safety outcome measurements of faricimab use in treatment-resistant neovascular age-related macular degeneration (nAMD) in a cohort of Asian patients. A tertiary hospital in central Singapore serving…
View article: Anti-VEGF treatment switch in real-world DME patients: ranibizumab versus aflibercept for bevacizumab DME non-responding patients (SWIRL study)
Anti-VEGF treatment switch in real-world DME patients: ranibizumab versus aflibercept for bevacizumab DME non-responding patients (SWIRL study) Open
Background/aims To describe the functional outcomes of patients with diabetic macular oedema (DME) non-responsive to bevacizumab switched to ranibizumab or aflibercept over 1 year and the demographic and anatomic predictors of these functi…
View article: Psychometric evaluation and computerized adaptive testing simulations of age-related macular degeneration quality of life item banks
Psychometric evaluation and computerized adaptive testing simulations of age-related macular degeneration quality of life item banks Open
Six IBs demonstrated acceptable psychometric properties and potential CAT efficiency, suggesting MacCAT provides a comprehensive measurement of the QoL impact of AMD and associated treatments. Further testing in larger clinical cohorts is …
View article: Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases
Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases Open
The Asia Pacific Inherited Eye Disease (APIED) network aims to (1) improve genotyping capabilities and expertise to increase early and accurate genetic diagnosis of IRDs, (2) harmonise deep phenotyping practices and utilization of ontologi…
View article: KESTREL and KITE Phase 3 Studies: 100-Week Results With Brolucizumab in Patients With Diabetic Macular Edema
KESTREL and KITE Phase 3 Studies: 100-Week Results With Brolucizumab in Patients With Diabetic Macular Edema Open
View article: IMPACT OF RETINAL FLUID-FREE MONTHS ON OUTCOMES IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
IMPACT OF RETINAL FLUID-FREE MONTHS ON OUTCOMES IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION Open
Purpose: To assess the effect of the total number of fluid-free months after loading on visual and anatomical outcomes in neovascular age-related macular degeneration patients receiving anti–vascular endothelial growth factor therapy. Meth…
View article: Diabetic Macular Edema Management in Asian Population: Expert Panel Consensus Guidelines
Diabetic Macular Edema Management in Asian Population: Expert Panel Consensus Guidelines Open
This consensus article provides comprehensive, evidence-based treatment guidelines in the management of DME in Asian population. In addition, it also provides recommendations on other aspects of DME management such as steroid treatment for…
View article: Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude
Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude Open
PACG patients have poorer sleep quality but not daytime sleepiness. This is important in South-East Asian population with heavy disease burden. Evaluations on sleep disturbances can be considered to provide more holistic care.
View article: A longitudinal study of choroidal changes following cataract surgery in patients with diabetes
A longitudinal study of choroidal changes following cataract surgery in patients with diabetes Open
Objective: To study the structural changes in the choroid of diabetic patients following cataract surgery, using choroidal vascularity index and choroidal thickness. Methods: A prospective case–control study was conducted in 18 diabetic an…
View article: Human pharyngeal microbiota in age-related macular degeneration
Human pharyngeal microbiota in age-related macular degeneration Open
Utilizing an extensive study population from Singapore, our results provided an accurate description of the pharyngeal microbiota profiles in AMD health and disease conditions. Through identification of candidate genera that are different …
View article: Eye gaze tracking and its relationship with visual acuity, central visual field and age-related macular degeneration features.
Eye gaze tracking and its relationship with visual acuity, central visual field and age-related macular degeneration features. Open
View article: A bilayer photoreceptor-retinal tissue model with gradient cell density design: A study of microvalve-based bioprinting
A bilayer photoreceptor-retinal tissue model with gradient cell density design: A study of microvalve-based bioprinting Open
ARPE-19 and Y79 cells were precisely and effectively delivered to form an in vitro retinal tissue model via 3D cell bioprinting technology. The samples were characterized by cell viability assay, haematoxylin and eosin and immunofluorescen…
View article: Automated retinal health diagnosis using pyramid histogram of visual words and Fisher vector techniques
Automated retinal health diagnosis using pyramid histogram of visual words and Fisher vector techniques Open
View article: HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization
HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization Open
BACKGROUND: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological stu…
View article: The effect of intravitreal injections on dry eye, and proposed management strategies
The effect of intravitreal injections on dry eye, and proposed management strategies Open
Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents has become a commonly used treatment method for a number of ophthalmic conditions, including age-related macular degeneration. Although anti-VEGF therapy …
View article: Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study Open
The water-drinking test (WDT) is a provocative test used in glaucoma research to assess the effects of elevated intraocular pressure (IOP). Defective autoregulation due to changes in perfusion pressure may play a role in the pathophysiolog…
View article: Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research
Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research Open
In this article, a hybrid retina construct was created via three-dimensional (3D) bioprinting technology. The construct was composed of a PCL ultrathin membrane, ARPE-19 cell monolayer and Y79 cell-laden alginate/pluronic bioink. 3D biopri…
View article: An automated system to assess eye movement characteristics for individuals with visual impairment in age-related macular degeneration
An automated system to assess eye movement characteristics for individuals with visual impairment in age-related macular degeneration Open
View article: 3D printed bio-models for medical applications
3D printed bio-models for medical applications Open
Purpose The design process of a bio-model involves multiple factors including data acquisition technique, material requirement, resolution of the printing technique, cost-effectiveness of the printing process and end-use requirements. This…
View article: Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans
Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans Open
To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and poly…
View article: Investigation of cell viability and morphology in 3D bio‐printed alginate constructs with tunable stiffness
Investigation of cell viability and morphology in 3D bio‐printed alginate constructs with tunable stiffness Open
In this article, mouse fibroblast cells (L929) were seeded on 2%, 5%, and 10% alginate hydrogels, and they were also bio‐printed with 2%, 5%, and 10% alginate solutions individually to form constructs. The elastic and viscous moduli of alg…
View article: Giant non-pulsatile polypoidal choroidal vasculopathy
Giant non-pulsatile polypoidal choroidal vasculopathy Open
View article: A biodegradable ultra-thin membrane for retinal tissue engineering: preliminary study using ARPE-19 cells.
A biodegradable ultra-thin membrane for retinal tissue engineering: preliminary study using ARPE-19 cells. Open
View article: Assessment of the choroid following cataract surgery in diabetic patients using choroidal thickness and vascularity index as optical coherence tomography parameters
Assessment of the choroid following cataract surgery in diabetic patients using choroidal thickness and vascularity index as optical coherence tomography parameters Open
View article: Drug, delivery and devices for diabetic retinopathy (3Ds in DR)
Drug, delivery and devices for diabetic retinopathy (3Ds in DR) Open
Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was cond…
View article: An Automated System for Multi-model Retinal Image Registration using Novel Low-dimensional Features
An Automated System for Multi-model Retinal Image Registration using Novel Low-dimensional Features Open
View article: Automated microaneurysm detection in diabetic retinopathy using curvelet transform
Automated microaneurysm detection in diabetic retinopathy using curvelet transform Open
Microaneurysms (MAs) are known to be the early signs of diabetic retinopathy (DR). An automated MA detection system based on curvelet transform is proposed for color fundus image analysis. Candidates of MA were extracted in two parallel st…
View article: Application of higher-order spectra for automated grading of diabetic maculopathy
Application of higher-order spectra for automated grading of diabetic maculopathy Open
View article: Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians Open
Nature Communications 6: Article number: 6063 (2015); Published 28 January 2015; Updated 30 March 2015. The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the following: This study …
View article: New loci and coding variants confer risk for age-related macular degeneration in East Asians
New loci and coding variants confer risk for age-related macular degeneration in East Asians Open