Aum R. Patel
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View article: Cytokine-Driven Janus Kinase Signal Transducer and Activator of Transcription (JAK/STAT) Pathway Hyperactivity Predicts Disease Severity in Pediatric Focal Segmental Glomerulosclerosis
Cytokine-Driven Janus Kinase Signal Transducer and Activator of Transcription (JAK/STAT) Pathway Hyperactivity Predicts Disease Severity in Pediatric Focal Segmental Glomerulosclerosis Open
Background: Focal segmental glomerulosclerosis (FSGS) accounts for approximately 20% of cases of pediatric nephrotic syndrome and is the leading cause of end-stage kidney disease among glomerular disorders in the US. Primary FSGS is though…
View article: Alveolar macrophages are early targets of mumps virus 2177
Alveolar macrophages are early targets of mumps virus 2177 Open
Description Mumps virus (MuV) remains active worldwide, despite high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellular targets of MuV in vivo are unknow…
View article: Alveolar macrophages are early targets of mumps virus
Alveolar macrophages are early targets of mumps virus Open
Formerly a common childhood pathogen, mumps virus (MuV) remains active worldwide, despite relatively high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellu…
View article: Immunological landscape of human lymphoid explants during measles virus infection
Immunological landscape of human lymphoid explants during measles virus infection Open
In humans, lymph nodes are the primary site of measles virus (MeV) replication. To understand the immunological events that occur at this site, we infected human lymphoid tissue explants using a pathogenic strain of MeV that expresses GFP.…
View article: Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus
Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus Open
View article: Immunological landscape of human lymphoid explants during measles virus infection
Immunological landscape of human lymphoid explants during measles virus infection Open
In humans, lymph nodes are the primary site of measles virus (MeV) replication. To understand the immunological events that occur at this site, we infected human lymphoid tissue explants using a pathogenic strain of MeV that expresses GFP.…
View article: Zoonotic potential of a novel bat morbillivirus
Zoonotic potential of a novel bat morbillivirus Open
View article: Infectivity of three Mayaro Virus (Genus Alphavirus, Family Togaviridae) geographic isolates in human cell lines
Infectivity of three Mayaro Virus (Genus Alphavirus, Family Togaviridae) geographic isolates in human cell lines Open
Mayaro virus (MAYV) is an emergent arthropod-borne virus that causes an acute febrile illness accompanied by arthralgia, similar to chikungunya virus. Increasing urbanization of MAYV outbreaks in the Americas has led to concerns that this …
View article: Assessing the zoonotic potential of a novel bat morbillivirus
Assessing the zoonotic potential of a novel bat morbillivirus Open
Morbilliviruses are amongst the most contagious viral pathogens that infect mammals. Metagenomic surveys have identified numerous morbillivirus sequences in bats, but no full-length authentic morbillivirus has been isolated or characterize…