Aurélie De Groof
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View article: Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases
Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases Open
Objective Anti‐Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective…
View article: Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases Open
Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This stud…
View article: O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases
O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases Open
Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification. Method…
View article: Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases Open
SUMMARY Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification…
View article: Additional file 2 of Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis
Additional file 2 of Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis Open
Additional file 2. Discovery proteomics data (accession number, protein names, p value, q-value, fold change status of identified proteins). List of common proteins between mouse kidney discovery proteomics and human kidney transcriptomics…
View article: Additional file 3 of Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis
Additional file 3 of Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis Open
Additional file 3. List of significantly enriched KEGG pathways identified by pathway analysis of discovery proteomic data at each time. Table S3.1: List of significantly enriched KEGG pathways at 12 weeks. Table S3.2: List of significantl…
View article: STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE
STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE Open
Objective Type I IFNs play a well-known role in the pathogenesis of SLE, through activation of CD4 T and antigen-presenting cells. Here, we investigated the effects of IFN alpha (IFNα) on SLE B cell activation and differentiation. Methods …
View article: Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β
Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β Open
Objective Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by ubiquitin ligases and substrate-specific ubiquitin-specific peptidases (USPs). The ubiquitination process also plays important roles in …
View article: Intrarenal activation of adaptive immune effectors is associated with tubular damage and impaired renal function in lupus nephritis
Intrarenal activation of adaptive immune effectors is associated with tubular damage and impaired renal function in lupus nephritis Open
Interstitial infiltration of LN kidney biopsies by adaptive immune effectors is associated with impaired renal tubular cell function and decreased eGFR. These results open new perspectives in evaluating and treating patients with LN, focus…
View article: Additional file 3: of Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy
Additional file 3: of Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy Open
Numbers of probe sets displaying a positive correlation with global disease activity indices and each of their individual variables. Overlap between probe sets displaying a Pearson r correlation coefficient >0.5 between tender joint count,…
View article: Additional file 4: of Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy
Additional file 4: of Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy Open
Genes over-expressed in poor responders to therapy at baseline. Lists of probe sets differentially expressed at baseline in synovial biopsies from patients with early rheumatoid arthritis (RA) in good versus poor responders to first line t…