Aurélie Fricot
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View article: Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease
Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease Open
The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the spleni…
View article: Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte
Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte Open
Within the human host, the symptoms of malaria are caused by the replication of malaria parasites within erythrocytes. Growth inside the erythrocyte exposes the parasites to the normal surveillance of erythrocytes by the host organism, in …
View article: Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance
Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance Open
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologica…
View article: Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease
Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease Open
In children with sickle cell disease (SCD), splenectomy is immediately beneficial for acute sequestration crises and hypersplenism (ASSC/HyS) but portends a long‐term risk of asplenia‐related complications. We retrieved peripheral and sple…
View article: Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance
Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance Open
Although refrigerated storage slows the metabolism of volunteer donor RBCs, cellular aging still occurs throughout this in vitro process, which is essential in transfusion medicine. Storage-induced microerythrocytes (SMEs) are morphologica…
View article: Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria
Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria Open
Splenomegaly frequently occurs in patients with Plasmodium falciparum (Pf) or P. vivax (Pv) malarial anemia, but mechanisms underlying this co‐occurrence are unclear. In malaria‐endemic Papua, Indonesia, we prospectively analyzed red blood…
View article: Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening Open
Malaria parasites like Plasmodium falciparum multiply in red blood cells (RBC), which are cleared from the bloodstream by the spleen when their deformability is altered. Drug-induced stiffening of Plasmodium falciparum -infected RBC should…
View article: Erythrocytic vacuoles that accumulate a fluorescent dye predict spleen size and function in sickle cell disease
Erythrocytic vacuoles that accumulate a fluorescent dye predict spleen size and function in sickle cell disease Open
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View article: P-061: DE NOVO APPEARANCE OF VACUOLES IN TRANSFUSED RED BLOOD CELLS IN SICKLE CELL DISEASE PATIENTS WITH DEFECTIVE SPLENIC FUNCTION
P-061: DE NOVO APPEARANCE OF VACUOLES IN TRANSFUSED RED BLOOD CELLS IN SICKLE CELL DISEASE PATIENTS WITH DEFECTIVE SPLENIC FUNCTION Open
Purpose: Defective spleen function (hyposplenism) affects subjects with sickle cell disease (SCD) and is associated with complications. Red blood cell (RBC)-related markers are very accurate to assess spleen function. Vacuole-containing RB…
View article: O-11: AUTOMATED QUANTIFICATION OF POCKED RED BLOOD CELLS CORRELATES WITH SPLEEN SIZE IN SICKLE CELL DISEASE
O-11: AUTOMATED QUANTIFICATION OF POCKED RED BLOOD CELLS CORRELATES WITH SPLEEN SIZE IN SICKLE CELL DISEASE Open
Purpose: The spleen is a lymphoid organ that protects the body against blood infections and filters blood cells. Defective spleen function (hyposplenism) is caused by splenectomy or by immunological or hematological diseases. Counting vacu…
View article: Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria
Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria Open
View article: PB2216: VACUOLES APPEAR IN RED BLOOD CELLS TRANSFUSED TO PATIENTS WITH SICKLE CELL DISEASE-RELATED HYPOSPLENISM
PB2216: VACUOLES APPEAR IN RED BLOOD CELLS TRANSFUSED TO PATIENTS WITH SICKLE CELL DISEASE-RELATED HYPOSPLENISM Open
Background: Defective spleen function (hyposplenism) affects subjects with sickle cell disease (SCD) and is associated with complications. Red blood cell (RBC) alterations are very accurate markers of spleen function. Vacuole-containing RB…
View article: P1496: OPERATOR-INDEPENDENT, FLUORESCENCE-BASED QUANTIFICATION OF POCKED RED CELLS CORRELATES WITH SPLEEN SIZE AND FUNCTION IN SICKLE CELL DISEASE
P1496: OPERATOR-INDEPENDENT, FLUORESCENCE-BASED QUANTIFICATION OF POCKED RED CELLS CORRELATES WITH SPLEEN SIZE AND FUNCTION IN SICKLE CELL DISEASE Open
Background: The spleen protects against blood-borne infections, contributes to the maturation of reticulocytes. Defective spleen function (hyposplenism) is caused by splenectomy or by immunological or hematological diseases. It occurs very…
View article: Altered Subpopulations of Red Blood Cells and Post-treatment Anemia in Malaria
Altered Subpopulations of Red Blood Cells and Post-treatment Anemia in Malaria Open
In acute malaria, the bulk of erythrocyte loss occurs after therapy, with a nadir of hemoglobin generally observed 3–7 days after treatment. The fine mechanisms leading to this early post-treatment anemia are still elusive. We explored pat…
View article: Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria
Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria Open
In malaria-endemic areas, subjects from specific groups like Fulani have a peculiar protection against malaria, with high levels of IgM but also frequent anemia and splenomegaly. The mechanisms underlying this phenotype remain elusive. In …
View article: Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study
Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study Open
Background A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax . The mechanisms underlying this intense tropism are not clear. We hypothe…
View article: Hidden Biomass of Intact Malaria Parasites in the Human Spleen
Hidden Biomass of Intact Malaria Parasites in the Human Spleen Open
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View article: Rapid clearance of storage-induced microerythrocytes alters transfusion recovery
Rapid clearance of storage-induced microerythrocytes alters transfusion recovery Open
Permanent availability of red blood cells (RBCs) for transfusion depends on refrigerated storage, during which morphologically altered RBCs accumulate. Among these, a subpopulation of small RBCs, comprising type III echinocytes, spheroechi…
View article: A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease
A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease Open
The most common treatment for patients with sickle cell disease (SCD) is the chemotherapeutic hydroxyurea, a therapy with pleiotropic effects, including increasing fetal hemoglobin (HbF) in red blood cells and reducing adhesion of white bl…
View article: Serum Iron Protects from Renal Postischemic Injury
Serum Iron Protects from Renal Postischemic Injury Open
Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion…