Aurélie Vadel
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View article: THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA
THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA Open
The current paradigm about the function of T cell immune checkpoints is that these receptors switch on inhibitory signals upon cognate ligand interaction. We here revisit this simple switch model and provide evidence that the T cell lineag…
View article: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis Open
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcri…
View article: Author response: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis
Author response: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis Open
View article: Involvement of FGFR4 in Pulmonary Fibrosis Pathophysiology
Involvement of FGFR4 in Pulmonary Fibrosis Pathophysiology Open
Rationale :Idiopathic Pulmonary Fibrosis (IPF) is characterized by the reactivation of developmental pathways, such as Fibroblast Growth Factors (FGF).FGFR4, a FGF receptor which is not targeted by nintedanib, has been suggested to modulat…
View article: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis Open
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcri…
View article: Fibroblast Growth Facor 19, a Downregulated Factor in Idiopathic Pulmonary Fibrosis, Inhibits Mice Lung Fibrosis
Fibroblast Growth Facor 19, a Downregulated Factor in Idiopathic Pulmonary Fibrosis, Inhibits Mice Lung Fibrosis Open
View article: A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis
A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis Open
View article: TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling
TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling Open
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterised by myofibroblast proliferation and abnormal extracellular matrix accumulation in the lungs. Transforming growth factor (TGF)-β1 initiates key profibrotic…