Aurélien Bidaud-Meynard
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View article: Correction: High-resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border
Correction: High-resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border Open
View article: Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine
Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine Open
View article: The clathrin adaptor AP-1B independently controls proliferation and differentiation in the mammalian intestine
The clathrin adaptor AP-1B independently controls proliferation and differentiation in the mammalian intestine Open
Maintenance of the polarity of the epithelial cells facing the lumen of the small intestine is crucial to ensure the vectorial absorption of nutrients as well as the integrity of the apical brush border and the intestinal barrier. Polarize…
View article: Sparse denoising and adaptive estimation enhances the resolution and contrast of fluorescence emission difference microscopy based on an array detector
Sparse denoising and adaptive estimation enhances the resolution and contrast of fluorescence emission difference microscopy based on an array detector Open
An array detector allows a resolution gain for confocal microscopy by combining images sensed by a set of photomultipliers tubes (or sub-detectors). Several methods have been proposed to reconstruct a high-resolution image by linearly comb…
View article: V<sub>0</sub>-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine
V<sub>0</sub>-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine Open
Summary Intestinal microvillus atrophy is a major cause of enteropathies such as idiopathic or congenital diarrhea that are often associated with severe morbidity. It can be caused by genetic disorders, inflammatory diseases, toxins or pat…
View article: High-resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border
High-resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border Open
The intestinal brush border is made of an array of microvilli that increases the membrane surface area for nutrient processing, absorption and host defense. Studies on mammalian cultured epithelial cells have uncovered some of the molecula…
View article: A comparison of high resolution image reconstruction methods from confocal array detector with a new deconvolution algorithm
A comparison of high resolution image reconstruction methods from confocal array detector with a new deconvolution algorithm Open
Array detector allows a resolution gain for confocal microscopy by combining images sensed by a set of photomultipliers tubes (or sub-detectors). Several methods have been proposed to reconstruct a high resolution image by linearly combini…
View article: High resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border
High resolution dynamic mapping of the <i>C. elegans</i> intestinal brush border Open
The intestinal brush border is made of an array of microvilli that increases the membrane surface area for nutrient processing, absorption, and host defence. Studies on mammalian cultured epithelial cells uncovered some of the molecular pl…
View article: Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting
Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting Open
Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases. Maintenance of apical polarity in the face of CFTR non-…
View article: A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane Open
Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining genetic RNAi screen and in vivo super-resolution imaging in the C. elegans …
View article: A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane Open
Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining genetic RNAi screen and in vivo super-resolution imaging in the C . elegans…
View article: Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting
Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting Open
SUMMARY Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases. Maintenance of apical polarity in the face of C…
View article: Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids
Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids Open
View article: Mutation-specific downregulation of CFTR2 variants by gating potentiators
Mutation-specific downregulation of CFTR2 variants by gating potentiators Open
Approximately 50% of cystic fibrosis (CF) patients are heterozygous with a rare mutation on at least one allele. Several mutants exhibit functional defects, correctable by gating potentiators. Long-term exposure (≥24 h) to the only availab…
View article: Regulation of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP
Regulation of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP Open
Cell migration, a key feature of embryonic development, immunity, angiogenesis, and tumor metastasis, is based on the coordinated regulation of actin dynamics and integrin-mediated adhesion. Rho GTPases play a major role in this phenomenon…
View article: <i>RPL12</i> knockdown increases the stability of the core- and complex-glycosylated forms of ΔF508-CFTR.
<i>RPL12</i> knockdown increases the stability of the core- and complex-glycosylated forms of ΔF508-CFTR. Open
(A, B)RPL12 ablation increases the conformational stability of the solubilised rΔF508-CFTR. The thermoaggregation propensity of rΔF508-CFTR as a surrogate indicator of the channel conformational stability was determined in ce…
View article: SiRNA-mediated silencing of ribosomal stalk proteins enhances the PM density, function, and stability of ΔF508-CFTR.
SiRNA-mediated silencing of ribosomal stalk proteins enhances the PM density, function, and stability of ΔF508-CFTR. Open
(A, B) The effect of ribosomal stalk protein (RPLP0—P0, RPLP1—P1, and PRPL2—P2) and eEF-2 knockdown on the PM density (A) and function (B) of rΔF508-CFTR in CFBE. The indicated ribosomal proteins were silenced with two to three indi…
View article: <i>RPL12</i> knockdown increases the maturation efficiency of some misfolded membrane proteins.
<i>RPL12</i> knockdown increases the maturation efficiency of some misfolded membrane proteins. Open
(A–D) PM densities of the indicated proteins were measured by cell surface ELISA in NT or RPL12 siRNA transfected HeLa cells. In A–C, cells stably expressing extracellular HA-epitope tagged V2R-Y128S (A, n = 3), MLC1-P…
View article: Yeast deletion suppressors of Yor1-ΔF670 grouped by functional module with human homologs and functional annotations.
Yeast deletion suppressors of Yor1-ΔF670 grouped by functional module with human homologs and functional annotations. Open
Yeast deletion suppressors of Yor1-ΔF670 grouped by functional module with human homologs and functional annotations.
View article: <i>RPL12</i> knockdown is additive with VX-809 in primary CF human bronchial epithelia (HBE).
<i>RPL12</i> knockdown is additive with VX-809 in primary CF human bronchial epithelia (HBE). Open
(A) The effect of RPL12 knockdown, VX-809 treatment (3 μM, 24 h) or combination of both on the expression pattern of endogenous ΔF508-CFTR in HBE cells isolated from one CF patient with CFTRΔF508/ΔF508
View article: Slow-down of translational elongation rate partially corrects ΔF508-CFTR folding defects.
Slow-down of translational elongation rate partially corrects ΔF508-CFTR folding defects. Open
(A, B) Schematic depiction of the run-off elongation experiment (A) and relative translation elongation rates in HeLa cells transfected with RPL12 or NT siRNA (B). The values were normalized to cells in which the initiation w…
View article: <i>RPL12</i> knockdown increases the conformational maturation of ΔF508-CFTR at the ER.
<i>RPL12</i> knockdown increases the conformational maturation of ΔF508-CFTR at the ER. Open
(A) Determination of ΔF508-CFTR translation and ER folding efficiency by metabolic pulse chase in CFBE and HeLa cells transfected with RPL12 or NT siRNA. Labeling with [35S]-methionine and [35S]-cysteine…
View article: Genes involved in the function of the cytoplasmic exosome, nuclear exosome, rRNA processing and ribosome influence the function of Yor1-ΔF670.
Genes involved in the function of the cytoplasmic exosome, nuclear exosome, rRNA processing and ribosome influence the function of Yor1-ΔF670. Open
(A) Box-whisker plot of the cell proliferation parameter L (time to reach half-maximal carrying capacity) of the yor1-Δ0 (gene deletion) strain (cyan) and the yor1-ΔF670 mutant (magenta) following treatment with oligom…
View article: Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration
Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration Open
Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activati…
View article: Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Open
The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of s…