Aurélien Lebrun
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View article: Catalyst Selection for Body-Temperature Curable Polyurethane Networks from Poly(δ-Decalactone) and Lysine Diisocyanate
Catalyst Selection for Body-Temperature Curable Polyurethane Networks from Poly(δ-Decalactone) and Lysine Diisocyanate Open
With aging, harsh working conditions or sports injuries, the meniscus can degrade, causing pains to the patient. Nowadays, the treatment consists of the surgical replacement of this cartilage. Since this procedure can lead to complications…
View article: Double Gyroid‐Forming Hybrid Anion Exchange Membranes With Superior Mechanical Properties
Double Gyroid‐Forming Hybrid Anion Exchange Membranes With Superior Mechanical Properties Open
Nanostructured hybrid anion exchange membranes (AEMs) with enhanced mechanical properties were fabricated by first applying a solvent vapor annealing (SVA) treatment to a block copolymer (BCP) film, enabling the formation of a double gyroi…
View article: Third‐Generation CD73 Inhibitors Based on a 4,6‐Disubstituted‐2‐Thiopyridine Scaffold
Third‐Generation CD73 Inhibitors Based on a 4,6‐Disubstituted‐2‐Thiopyridine Scaffold Open
Various series of 4,6‐disubstituted‐2‐thiopyridine derivatives were synthesized and evaluated as potential ecto‐5’‐nucleotidase (CD73) inhibitors. Altogether, about ninety compounds were prepared using a general synthetic pathway involving…
View article: Star poly(lactide-co-glycolide) and poly(ε-caprolactone) polyurethanes with shape memory properties for biomedical applications
Star poly(lactide-co-glycolide) and poly(ε-caprolactone) polyurethanes with shape memory properties for biomedical applications Open
International audience
View article: Selective acylation of chitosan oligomers by several cyclic anhydrides as a 13C NMR quantification method
Selective acylation of chitosan oligomers by several cyclic anhydrides as a 13C NMR quantification method Open
International audience
View article: Paving the Way towards Sustainability of Polyurethanes: Synthesis and Properties of Terpene-Based Diisocyanate
Paving the Way towards Sustainability of Polyurethanes: Synthesis and Properties of Terpene-Based Diisocyanate Open
Due to growing concerns about environmental issues and the decline of petroleum-based resources, the synthesis of new biobased compounds for the polymer industry has become a prominent and timely topic. P-menthane-1,8-diamine (PMDA) is a r…
View article: One‐Pot Synthesis of Bioinspired Peptide‐Decorated Apatite Nanoparticles for Nanomedicine
One‐Pot Synthesis of Bioinspired Peptide‐Decorated Apatite Nanoparticles for Nanomedicine Open
Hybrid organic–inorganic bio‐inspired apatite nanoparticles (NPs) are attractive for biomedical applications and especially in nanomedicine. Unfortunately, their applications in nanomedicine are limited by their broad particle size distrib…
View article: Fast and Cost‐Efficient <sup>17</sup> O‐Isotopic Labeling of Carboxylic Groups in Biomolecules: From Free Amino Acids to Peptide Chains
Fast and Cost‐Efficient <sup>17</sup> O‐Isotopic Labeling of Carboxylic Groups in Biomolecules: From Free Amino Acids to Peptide Chains Open
17 O NMR spectroscopy is a powerful technique, which can provide unique information regarding the structure and reactivity of biomolecules. However, the low natural abundance of 17 O (0.04 %) generally requires working with enriched sample…
View article: Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly
Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly Open
Dynamic covalent polymers (DCPs) offer opportunities as adaptive materials of particular interest for targeting, sensing and delivery of biological molecules. In this view, combining cationic units and fluorescent units along DCP chains is…
View article: Fast and cost-efficient approaches for 17O-isotopic labeling of carboxylic groups in biomolecules: from free amino acids to peptide chains
Fast and cost-efficient approaches for 17O-isotopic labeling of carboxylic groups in biomolecules: from free amino acids to peptide chains Open
17O NMR spectroscopy is a powerful analytical technique, which enables to access unique information regarding the structure and reactivity of biomolecules, such as peptides and proteins. However, due to the exceedingly low natural abundanc…
View article: Fast and cost-efficient approaches for 17O-isotopic labeling of carboxylic groups in biomolecules: from free amino acids to peptide chains
Fast and cost-efficient approaches for 17O-isotopic labeling of carboxylic groups in biomolecules: from free amino acids to peptide chains Open
17O NMR spectroscopy is a powerful analytical technique, which enables to access unique information regarding the structure and reactivity of biomolecules, such as peptides and proteins. However, due to the exceedingly low natural abundanc…
View article: Synthesis, Characterization, and Encapsulation Properties of Rigid and Flexible Porphyrin Cages Assembled from <i>N</i>-Heterocyclic Carbene–Metal Bonds
Synthesis, Characterization, and Encapsulation Properties of Rigid and Flexible Porphyrin Cages Assembled from <i>N</i>-Heterocyclic Carbene–Metal Bonds Open
Four porphyrins equipped with imidazolium rings on the para positions of their meso aryl groups were prepared and used as tetrakis(N-heterocyclic carbene) (NHC) precursors for the synthesis of porphyrin cages assembled from eight NHC-M bon…
View article: A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells’ Oxidative Stress Defense Pathway
A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells’ Oxidative Stress Defense Pathway Open
The aim of our study was to identify novel molecules able to induce an adaptative response against oxidative stress during the first stages of metabolic syndrome. A cellular survival in vitro test against H2O2-based test was applied after …
View article: Cost-efficient and user-friendly <sup>17</sup>O/<sup>18</sup>O labeling procedures of fatty acids using mechanochemistry
Cost-efficient and user-friendly <sup>17</sup>O/<sup>18</sup>O labeling procedures of fatty acids using mechanochemistry Open
Two mechanochemical procedures for 17O/18O-isotope labeling of fatty acids are reported: a carboxylic acid activation/hydrolysis approach and a saponification approach.
View article: Unveiling the Structure and Reactivity of Fatty-Acid Based (Nano)materials Thanks to Efficient and Scalable <sup>17</sup>O and <sup>18</sup>O-Isotopic Labeling Schemes
Unveiling the Structure and Reactivity of Fatty-Acid Based (Nano)materials Thanks to Efficient and Scalable <sup>17</sup>O and <sup>18</sup>O-Isotopic Labeling Schemes Open
Fatty acids are ubiquitous in biological systems and widely used in materials science, including for the formulation of drugs and the surface-functionalization of nanoparticles. However, important questions regarding the structure and reac…
View article: Inorganic Sol–Gel Polymerization for Hydrogel Bioprinting
Inorganic Sol–Gel Polymerization for Hydrogel Bioprinting Open
An inorganic sol-gel polymerization process was used as a cross-linking reaction during three-dimensional (3D) bioprinting of cell-containing hydrogel scaffolds. Hybrid hydroxypropyl methyl cellulose (HPMC), with a controlled ratio of sily…
View article: DNA‐Based Asymmetric Inverse Electron‐Demand Hetero‐Diels–Alder
DNA‐Based Asymmetric Inverse Electron‐Demand Hetero‐Diels–Alder Open
While artificial cyclases hold great promise in chemical synthesis, this work presents the first example of a DNA‐catalyzed inverse electron‐demand hetero‐Diels–Alder (IEDHDA) between dihydrofuran and various α,β‐unsaturated acyl imidazole…
View article: CCDC 1937831: Experimental Crystal Structure Determination
CCDC 1937831: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1937832: Experimental Crystal Structure Determination
CCDC 1937832: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1937833: Experimental Crystal Structure Determination
CCDC 1937833: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Molecular complexes and main-chain organometallic polymers based on Janus bis(carbenes) fused to metalloporphyrins
Molecular complexes and main-chain organometallic polymers based on Janus bis(carbenes) fused to metalloporphyrins Open
Janus bis(N-heterocyclic carbenes) composed of a porphyrin core with two N-heterocyclic carbene (NHC) heads fused to opposite pyrroles were used as bridging ligands for the preparation of metal complexes.
View article: Iron-Catalyzed Enantioselective Intramolecular Inverse Electron-Demand Hetero Diels–Alder Reactions: An Access to Bicyclic Dihydropyran Derivatives
Iron-Catalyzed Enantioselective Intramolecular Inverse Electron-Demand Hetero Diels–Alder Reactions: An Access to Bicyclic Dihydropyran Derivatives Open
A highly enantioselective iron-catalyzed Intramolecular Inverse Electron-Demand Hetero Diels-Alder (IIEDHDA) reaction is reported. By using a chiral semicorrin ligand in the presence of 2,6-lutidine, good isolated yields and excellent enan…
View article: Fused Bis-lactams to Spirolactams: A New Member of the Family of Ring- Contraction Reaction
Fused Bis-lactams to Spirolactams: A New Member of the Family of Ring- Contraction Reaction Open
International audience
View article: CCDC 1533647: Experimental Crystal Structure Determination
CCDC 1533647: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1851713: Experimental Crystal Structure Determination
CCDC 1851713: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1851714: Experimental Crystal Structure Determination
CCDC 1851714: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …